Entry Database : PDB / ID : 3jrv Structure visualization Downloads & linksTitle Structure of poxvirus K7 protein in complex with RNA helicase DDX3 ComponentsATP-dependent RNA helicase DDX3X Protein K7 DetailsKeywords VIRAL PROTEIN/PROTEIN BINDING / poxvirus protein K7 / DEAD-box RNA Helicase DDX3 / viral immune evasion / innate immunity / VIRAL PROTEIN-PROTEIN BINDING complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of protein acetylation / CTPase activity / positive regulation of toll-like receptor 8 signaling pathway / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of chemokine (C-C motif) ligand 5 production / protein localization to cytoplasmic stress granule / eukaryotic initiation factor 4E binding / RNA strand annealing activity / RNA secondary structure unwinding ... positive regulation of protein acetylation / CTPase activity / positive regulation of toll-like receptor 8 signaling pathway / positive regulation of toll-like receptor 7 signaling pathway / positive regulation of translation in response to endoplasmic reticulum stress / positive regulation of chemokine (C-C motif) ligand 5 production / protein localization to cytoplasmic stress granule / eukaryotic initiation factor 4E binding / RNA strand annealing activity / RNA secondary structure unwinding / gamete generation / NLRP3 inflammasome complex / positive regulation of protein K63-linked ubiquitination / cellular response to arsenic-containing substance / poly(A) binding / P granule / RNA stem-loop binding / cellular response to osmotic stress / gamma-tubulin binding / negative regulation of non-canonical NF-kappaB signal transduction / positive regulation of NLRP3 inflammasome complex assembly / cell leading edge / lipid homeostasis / positive regulation of interferon-alpha production / ribosomal small subunit binding / positive regulation of translational initiation / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / transcription factor binding / extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of type I interferon production / positive regulation of G1/S transition of mitotic cell cycle / positive regulation of viral genome replication / negative regulation of protein-containing complex assembly / negative regulation of intrinsic apoptotic signaling pathway / signaling adaptor activity / stress granule assembly / translation initiation factor binding / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / translational initiation / positive regulation of protein autophosphorylation / DNA helicase activity / positive regulation of interferon-beta production / protein serine/threonine kinase activator activity / ribonucleoside triphosphate phosphatase activity / intrinsic apoptotic signaling pathway / protein sequestering activity / cytosolic ribosome assembly / positive regulation of translation / chromosome segregation / response to virus / mRNA 5'-UTR binding / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of protein serine/threonine kinase activity / negative regulation of cell growth / Wnt signaling pathway / cellular response to virus / cytoplasmic stress granule / positive regulation of non-canonical NF-kappaB signal transduction / positive regulation of canonical Wnt signaling pathway / lamellipodium / : / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity / positive regulation of cell growth / secretory granule lumen / host cell cytoplasm / ficolin-1-rich granule lumen / negative regulation of translation / RNA helicase activity / cell differentiation / RNA helicase / intracellular signal transduction / cadherin binding / positive regulation of apoptotic process / mRNA binding / innate immune response / GTPase activity / centrosome / Neutrophil degranulation / positive regulation of gene expression / negative regulation of apoptotic process / ATP hydrolysis activity / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / extracellular exosome / extracellular region / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Orthopoxvirus, Protein K7 / dsDNA poxvirus / Poxvirus Bcl-2-like / Poxvirus domain superfamily / Poxvirus Bcl-2-like proteins / Apoptosis Regulator Bcl-x / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. ... Orthopoxvirus, Protein K7 / dsDNA poxvirus / Poxvirus Bcl-2-like / Poxvirus domain superfamily / Poxvirus Bcl-2-like proteins / Apoptosis Regulator Bcl-x / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Vaccinia virus WRMethod X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 1.6 Å DetailsAuthors Oda, S. / Khan, R.A. CitationJournal : Structure / Year : 2009Title : Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7Authors : Oda, S. / Schroder, M. / Khan, A.R. History Deposition Sep 9, 2009 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Nov 10, 2009 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Apr 18, 2012 Group : Database referencesRevision 1.3 Nov 1, 2017 Group : Refinement description / Category : software
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