regulation of Ras protein signal transduction / Polo-like kinase mediated events / regulation of reactive oxygen species metabolic process / positive regulation of double-strand break repair / negative regulation of stress-activated MAPK cascade / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / Cyclin A/B1/B2 associated events during G2/M transition / regulation of cell growth / RNA polymerase II transcription regulatory region sequence-specific DNA binding / G2/M transition of mitotic cell cycle ...regulation of Ras protein signal transduction / Polo-like kinase mediated events / regulation of reactive oxygen species metabolic process / positive regulation of double-strand break repair / negative regulation of stress-activated MAPK cascade / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / Cyclin A/B1/B2 associated events during G2/M transition / regulation of cell growth / RNA polymerase II transcription regulatory region sequence-specific DNA binding / G2/M transition of mitotic cell cycle / regulation of cell population proliferation / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of cell cycle / DNA-binding transcription factor activity / DNA repair / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / chromatin / regulation of transcription by RNA polymerase II / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus Similarity search - Function
: / Forkhead box protein M1 / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. ...: / Forkhead box protein M1 / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
A: Forkhead box protein M1 B: Forkhead box protein M1 C: DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*GP*CP*CP*CP*G)-3') D: DNA (5'-D(P*TP*TP*CP*GP*GP*GP*CP*TP*GP*TP*TP*TP*AP*TP*AP*AP*AP*CP*AP*AP*T)-3') hetero molecules
Mass: 18.015 Da / Num. of mol.: 163 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 3.1 Å3/Da / Density % sol: 60.38 %
Crystal grow
Temperature: 291 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: 24% PEG3350, 0.2M Sodium Malonate, pH7.5, 3uL Protein at 12g/L mixed with DNA at 0.5mM added tO 3uL of reservoir, VAPOR DIFFUSION, HANGING DROP, temperature 291K
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