登録情報 | データベース: PDB / ID: 3g5u |
---|
タイトル | Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding |
---|
要素 | Multidrug resistance protein 1a |
---|
キーワード | MEMBRANE PROTEIN / P-glycoprotein / multidrug resistance / Pgp / cyclic peptide |
---|
機能・相同性 | 機能・相同性情報
Atorvastatin ADME / Prednisone ADME / hormone transport / cellular response to nonylphenol / cellular response to borneol / response to codeine / response to cyclosporin A / cellular response to mycotoxin / daunorubicin transport / positive regulation of response to drug ...Atorvastatin ADME / Prednisone ADME / hormone transport / cellular response to nonylphenol / cellular response to borneol / response to codeine / response to cyclosporin A / cellular response to mycotoxin / daunorubicin transport / positive regulation of response to drug / terpenoid transport / ceramide floppase activity / negative regulation of sensory perception of pain / positive regulation of establishment of Sertoli cell barrier / regulation of intestinal absorption / cellular response to external biotic stimulus / response to quercetin / response to antineoplastic agent / ceramide translocation / floppase activity / ABC-family proteins mediated transport / establishment of blood-retinal barrier / phosphatidylethanolamine flippase activity / protein localization to bicellular tight junction / phosphatidylcholine floppase activity / xenobiotic transport across blood-brain barrier / response to thyroxine / establishment of blood-brain barrier / intercellular canaliculus / xenobiotic detoxification by transmembrane export across the plasma membrane / export across plasma membrane / P-type phospholipid transporter / cellular response to L-glutamate / response to vitamin A / ABC-type xenobiotic transporter / response to vitamin D / response to glycoside / response to alcohol / response to glucagon / intestinal absorption / ABC-type xenobiotic transporter activity / cellular response to antibiotic / phospholipid translocation / cellular hyperosmotic salinity response / maintenance of blood-brain barrier / cellular response to alkaloid / efflux transmembrane transporter activity / transmembrane transporter activity / xenobiotic transmembrane transporter activity / ATPase-coupled transmembrane transporter activity / cellular response to dexamethasone stimulus / response to cadmium ion / lactation / response to progesterone / placenta development / cellular response to estradiol stimulus / brush border membrane / female pregnancy / circadian rhythm / cellular response to tumor necrosis factor / cellular response to lipopolysaccharide / response to hypoxia / apical plasma membrane / response to xenobiotic stimulus / ATP hydrolysis activity / ATP binding / plasma membrane / cytoplasm類似検索 - 分子機能 ABC transporter transmembrane region fold / ABC transporter type 1, transmembrane domain / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter ...ABC transporter transmembrane region fold / ABC transporter type 1, transmembrane domain / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / P-loop containing nucleotide triphosphate hydrolases / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Up-down Bundle / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 : / ATP-dependent translocase ABCB1 / ATP-dependent translocase ABCB1類似検索 - 構成要素 |
---|
生物種 |  Mus musculus (ハツカネズミ) |
---|
手法 | X線回折 / シンクロトロン / 多波長異常分散 / 解像度: 3.8 Å |
---|
データ登録者 | Aller, S.G. / Yu, J. / Ward, A. / Weng, Y. / Chittaboina, S. / Zhuo, R. / Harrell, P.M. / Trinh, Y.T. / Zhang, Q. / Urbatsch, I.L. / Chang, G. |
---|
引用 | ジャーナル: Science / 年: 2009 タイトル: Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. 著者: Aller, S.G. / Yu, J. / Ward, A. / Weng, Y. / Chittaboina, S. / Zhuo, R. / Harrell, P.M. / Trinh, Y.T. / Zhang, Q. / Urbatsch, I.L. / Chang, G. |
---|
履歴 | 登録 | 2009年2月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2009年3月24日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2011年7月13日 | Group: Version format compliance |
---|
改定 1.2 | 2021年10月20日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
---|
改定 1.3 | 2024年2月21日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|