Entry Database : PDB / ID : 3fie Structure visualization Downloads & linksTitle Crystal structure of Clostridium botulinum neurotoxin serotype F catalytic domain with an inhibitor (inh1) ComponentsBOTULINUM NEUROTOXIN TYPE F fragment of Vesicle-associated membrane protein 2 DetailsKeywords HYDROLASE / TOXIN/PROTEIN TRANSPORT / Clostridium botulinum / BoNT F / VAMP / inhibitor / complex structure / Acetylation / Cell junction / TOXIN-PROTEIN TRANSPORT COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
Toxicity of tetanus toxin (tetX) / Toxicity of botulinum toxin type G (botG) / clathrin-sculpted glutamate transport vesicle membrane / regulation of delayed rectifier potassium channel activity / Toxicity of botulinum toxin type F (botF) / Toxicity of botulinum toxin type D (botD) / trans-Golgi Network Vesicle Budding / Acetylcholine Neurotransmitter Release Cycle / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex ... Toxicity of tetanus toxin (tetX) / Toxicity of botulinum toxin type G (botG) / clathrin-sculpted glutamate transport vesicle membrane / regulation of delayed rectifier potassium channel activity / Toxicity of botulinum toxin type F (botF) / Toxicity of botulinum toxin type D (botD) / trans-Golgi Network Vesicle Budding / Acetylcholine Neurotransmitter Release Cycle / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Toxicity of botulinum toxin type B (botB) / clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane / zymogen granule membrane / clathrin-sculpted monoamine transport vesicle membrane / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / Dopamine Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / eosinophil degranulation / vesicle fusion / SNARE complex / SNAP receptor activity / Glutamate Neurotransmitter Release Cycle / regulation of vesicle-mediated transport / bontoxilysin / calcium-ion regulated exocytosis / positive regulation of intracellular protein transport / host cell presynaptic membrane / Golgi to plasma membrane protein transport / regulation of exocytosis / host cell cytoplasmic vesicle / neuron projection terminus / Sensory processing of sound by inner hair cells of the cochlea / syntaxin-1 binding / SNARE complex assembly / syntaxin binding / clathrin-coated vesicle / host cell cytosol / Lysosome Vesicle Biogenesis / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / Other interleukin signaling / Golgi Associated Vesicle Biogenesis / Insulin processing / exocytosis / synaptic vesicle exocytosis / synaptic vesicle endocytosis / protein transmembrane transporter activity / response to glucose / vesicle-mediated transport / SNARE binding / secretory granule membrane / secretory granule / Regulation of insulin secretion / Translocation of SLC2A4 (GLUT4) to the plasma membrane / long-term synaptic potentiation / clathrin-coated endocytic vesicle membrane / trans-Golgi network / phospholipid binding / metalloendopeptidase activity / synaptic vesicle membrane / cellular response to insulin stimulus / calcium-dependent protein binding / protein transport / synaptic vesicle / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / toxin activity / cytoplasmic vesicle / protein-containing complex assembly / vesicle / membrane fusion / calmodulin binding / neuron projection / intracellular membrane-bounded organelle / lipid binding / synapse / host cell plasma membrane / perinuclear region of cytoplasm / proteolysis / zinc ion binding / extracellular region / membrane / plasma membrane / cytosol Similarity search - Function Synaptobrevin/Vesicle-associated membrane protein / Synaptobrevin signature. / Synaptobrevin-like / Synaptobrevin / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain ... Synaptobrevin/Vesicle-associated membrane protein / Synaptobrevin signature. / Synaptobrevin-like / Synaptobrevin / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily / Alpha-Beta Complex / Alpha Beta Similarity search - Domain/homologyBiological species Clostridium botulinum (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.1 Å DetailsAuthors Agarwal, R. / Swaminathan, S. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2009Title : Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F.Authors : Agarwal, R. / Schmidt, J.J. / Stafford, R.G. / Swaminathan, S. History Deposition Dec 11, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 23, 2009 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Sep 6, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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