Entry Database : PDB / ID : 2vxo Structure visualization Downloads & linksTitle Human GMP synthetase in complex with XMP ComponentsGMP SYNTHASE [GLUTAMINE-HYDROLYZING] Details Keywords LIGASE / PROTO-ONCOGENE / PHOSPHOPROTEIN / GUANINE MONOPHOSPHATE SYNTHETASE / GMP BIOSYNTHESIS / NUCLEOTIDE-BINDING / PURINE BIOSYNTHESIS / NUCLEOTIDE METABOLISM / GMPS / CASP8 / ATP-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
GMP synthase (glutamine-hydrolyzing) activity / GMP synthase activity / GMP synthase (glutamine-hydrolysing) / purine ribonucleoside monophosphate biosynthetic process / purine nucleobase biosynthetic process / Purine ribonucleoside monophosphate biosynthesis / GMP biosynthetic process / Azathioprine ADME / glutamine metabolic process / ATP binding / cytosol Similarity search - Function GMP synthase, C-terminal / GMP synthetase ATP pyrophosphatase domain / GMP synthase C terminal domain / GMP synthetase ATP pyrophosphatase (GMPS ATP-PPase) domain profile. / GMP synthase, glutamine amidotransferase / NAD/GMP synthase / NAD synthase / Glutamine amidotransferase class-I / Glutamine amidotransferase / Glutamine amidotransferase type 1 domain profile. ... GMP synthase, C-terminal / GMP synthetase ATP pyrophosphatase domain / GMP synthase C terminal domain / GMP synthetase ATP pyrophosphatase (GMPS ATP-PPase) domain profile. / GMP synthase, glutamine amidotransferase / NAD/GMP synthase / NAD synthase / Glutamine amidotransferase class-I / Glutamine amidotransferase / Glutamine amidotransferase type 1 domain profile. / Class I glutamine amidotransferase (GATase) domain / Class I glutamine amidotransferase-like / HUPs / Rossmann-like alpha/beta/alpha sandwich fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Welin, M. / Lehtio, L. / Andersson, J. / Arrowsmith, C.H. / Berglund, H. / Collins, R. / Dahlgren, L.G. / Edwards, A.M. / Flodin, S. / Flores, A. ...Welin, M. / Lehtio, L. / Andersson, J. / Arrowsmith, C.H. / Berglund, H. / Collins, R. / Dahlgren, L.G. / Edwards, A.M. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Johansson, A. / Johansson, I. / Karlberg, T. / Kotenyova, T. / Moche, M. / Nilsson, M.E. / Nyman, T. / Olesen, K. / Persson, C. / Sagemark, J. / Schueler, H. / Thorsell, A.G. / Tresaugues, L. / Van Den Berg, S. / Wisniewska, M. / Wikstrom, M. / Nordlund, P. CitationJournal : J.Mol.Biol. / Year : 2013Title : Substrate Specificity and Oligomerization of Human Gmp SynthetaseAuthors : Welin, M. / Lehtio, L. / Johansson, A. / Flodin, S. / Nyman, T. / Tresaugues, L. / Hammarstrom, M. / Graslund, S. / Nordlund, P. History Deposition Jul 8, 2008 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 12, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 10, 2013 Group : Database references / Derived calculations ... Database references / Derived calculations / Non-polymer description / Other / Source and taxonomy / Structure summary / Version format compliance Revision 1.2 Nov 13, 2013 Group : Database referencesRevision 1.3 Oct 16, 2019 Group : Data collection / Experimental preparation / OtherCategory : exptl_crystal_grow / pdbx_database_status / reflns_shellItem : _exptl_crystal_grow.method / _pdbx_database_status.status_code_sf / _reflns_shell.Rmerge_I_obsRevision 1.4 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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