登録情報 | データベース: PDB / ID: 2rnl |
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タイトル | Solution structure of the EGF-like domain from human Amphiregulin |
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要素 | Amphiregulin |
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キーワード | SIGNALING PROTEIN / AR / Colorectum cell-derived growth factor / EGF-like domain / CRDGF / Cytokine / Glycoprotein / Membrane / Polymorphism / Transmembrane / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI |
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機能・相同性 | 機能・相同性情報
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis / Inhibition of Signaling by Overexpressed EGFR / positive regulation of epidermal growth factor-activated receptor activity / EGFR interacts with phospholipase C-gamma / positive regulation of keratinocyte proliferation / mammary gland branching involved in thelarche / clathrin-coated vesicle membrane / COPII vesicle coating / negative regulation of epidermal growth factor receptor signaling pathway / Signaling by EGFR ...dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis / Inhibition of Signaling by Overexpressed EGFR / positive regulation of epidermal growth factor-activated receptor activity / EGFR interacts with phospholipase C-gamma / positive regulation of keratinocyte proliferation / mammary gland branching involved in thelarche / clathrin-coated vesicle membrane / COPII vesicle coating / negative regulation of epidermal growth factor receptor signaling pathway / Signaling by EGFR / membrane organization / Cargo concentration in the ER / COPII-mediated vesicle transport / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / epidermal growth factor receptor binding / negative regulation of osteoblast differentiation / GAB1 signalosome / epithelial cell proliferation involved in mammary gland duct elongation / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / mammary gland alveolus development / glial cell proliferation / endoplasmic reticulum to Golgi vesicle-mediated transport / response to glucocorticoid / response to cAMP / endoplasmic reticulum-Golgi intermediate compartment membrane / EGFR downregulation / cytokine activity / epidermal growth factor receptor signaling pathway / growth factor activity / ER to Golgi transport vesicle membrane / response to hydrogen peroxide / Constitutive Signaling by Aberrant PI3K in Cancer / response to peptide hormone / Cargo recognition for clathrin-mediated endocytosis / MAPK cascade / PIP3 activates AKT signaling / neuron projection development / Clathrin-mediated endocytosis / response to estradiol / cell-cell signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / Extra-nuclear estrogen signaling / membrane => GO:0016020 / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / G protein-coupled receptor signaling pathway / Golgi membrane / positive regulation of cell population proliferation / endoplasmic reticulum membrane / cell surface / signal transduction / extracellular space / extracellular region / nucleus類似検索 - 分子機能 Laminin / Laminin / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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データ登録者 | Qin, X. / Hayashi, F. / Terada, T. / Shirouzu, M. / Watanabe, S. / Kigawa, T. / Yabuta, N. / Nojima, H. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) |
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引用 | ジャーナル: To be Published タイトル: Solution structure of the EGF-like domain from human Amphiregulin 著者: Qin, X. / Hayashi, F. / Terada, T. / Shirouzu, M. / Watanabe, S. / Kigawa, T. / Yabuta, N. / Nojima, H. / Yokoyama, S. |
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履歴 | 登録 | 2008年1月11日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2009年1月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details |
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