Entry Database : PDB / ID : 2qwn Structure visualization Downloads & linksTitle Crystal structure of disulfide-bond-crosslinked complex of bovine hsc70 (1-386aa)R171C and bovine Auxilin (810-910aa)D876C in the ADP*Pi state ComponentsHeat shock cognate 71 kDa protein Putative tyrosine-protein phosphatase auxilin DetailsKeywords CHAPERONE / chaperone-cochaperone complex / ATP-binding / Nucleotide-binding / Nucleus / Phosphorylation / Stress response / Hydrolase / Protein phosphatase / SH3-bindingFunction / homology Function and homology informationFunction Domain/homology Component
regulation of clathrin coat assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / HSF1-dependent transactivation / Protein methylation / GABA synthesis, release, reuptake and degradation / PKR-mediated signaling / mRNA Splicing - Major Pathway / synaptic vesicle recycling / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ... regulation of clathrin coat assembly / Regulation of HSF1-mediated heat shock response / Attenuation phase / HSF1-dependent transactivation / Protein methylation / GABA synthesis, release, reuptake and degradation / PKR-mediated signaling / mRNA Splicing - Major Pathway / synaptic vesicle recycling / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / chaperone-mediated autophagy translocation complex disassembly / slow axonal transport / clathrin-uncoating ATPase activity / protein targeting to lysosome involved in chaperone-mediated autophagy / clathrin heavy chain binding / late endosomal microautophagy / synaptic vesicle uncoating / AUF1 (hnRNP D0) binds and destabilizes mRNA / clathrin coat disassembly / Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases / Clathrin-mediated endocytosis / clathrin-dependent endocytosis / Prp19 complex / presynaptic cytosol / clathrin-coated vesicle / postsynaptic cytosol / Neutrophil degranulation / clathrin binding / non-chaperonin molecular chaperone ATPase / chaperone cofactor-dependent protein refolding / intracellular transport / autophagosome / dephosphorylation / protein folding chaperone / heat shock protein binding / RNA splicing / protein tyrosine phosphatase activity / ATP-dependent protein folding chaperone / spliceosomal complex / terminal bouton / mRNA processing / SH3 domain binding / melanosome / presynapse / protein-macromolecule adaptor activity / protein refolding / vesicle / molecular adaptor activity / postsynaptic density / ribonucleoprotein complex / protein domain specific binding / lysosomal membrane / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / dendrite / nucleolus / ATP hydrolysis activity / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function DnaJ domain / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / Defensin A-like - #30 / DnaJ molecular chaperone homology domain / dnaJ domain profile. ... DnaJ domain / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / Defensin A-like - #30 / DnaJ molecular chaperone homology domain / dnaJ domain profile. / Chaperone J-domain superfamily / DnaJ domain / Defensin A-like / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Heat shock protein 70kD, C-terminal domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / C2 domain superfamily / ATPase, nucleotide binding domain / Helix Hairpins / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Bos taurus (cattle)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.4 Å DetailsAuthors Jiang, J. / Maes, E.G. / Wang, L. / Taylor, A.B. / Hinck, A.P. / Lafer, E.M. / Sousa, R. CitationJournal : Mol.Cell / Year : 2007Title : Structural basis of J cochaperone binding and regulation of Hsp70.Authors : Jiang, J. / Maes, E.G. / Taylor, A.B. / Wang, L. / Hinck, A.P. / Lafer, E.M. / Sousa, R. History Deposition Aug 10, 2007 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 18, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Refinement description / Version format complianceRevision 1.2 Oct 25, 2017 Group : Refinement description / Category : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version Revision 1.3 Oct 20, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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