- PDB-2qvk: The second Ca2+-binding domain of the Na+-Ca2+ exchanger is essen... -
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基本情報
登録情報
データベース: PDB / ID: 2qvk
タイトル
The second Ca2+-binding domain of the Na+-Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis
要素
Sodium/calcium exchanger 1
キーワード
METAL BINDING PROTEIN / CBD2 / calcium binding domain / sodium calcium exchanger
機能・相同性
機能・相同性情報
Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / sodium ion import across plasma membrane / intracellular sodium ion homeostasis / ankyrin binding / calcium ion import across plasma membrane ...Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / sodium ion import across plasma membrane / intracellular sodium ion homeostasis / ankyrin binding / calcium ion import across plasma membrane / positive regulation of the force of heart contraction / sodium ion transmembrane transport / positive regulation of bone mineralization / response to muscle stretch / calcium ion transmembrane transport / sarcolemma / postsynapse / calmodulin binding / axon / calcium ion binding / nucleoplasm / plasma membrane 類似検索 - 分子機能
Sodium/calcium exchanger, isoform 1 / CalX-beta domain / : / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily ...Sodium/calcium exchanger, isoform 1 / CalX-beta domain / : / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily / Sodium/calcium exchanger membrane region / Sodium/calcium exchanger protein / CalX-like domain superfamily / DnaJ domain / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性
解像度: 1.451→1.5 Å / 冗長度: 5.1 % / Rmerge(I) obs: 0.447 / Mean I/σ(I) obs: 2.85 / % possible all: 99.4
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解析
ソフトウェア
名称
バージョン
分類
HKL-2000
データ収集
SHELXS
位相決定
REFMAC
5.2
精密化
DENZO
データ削減
SCALEPACK
データスケーリング
精密化
構造決定の手法: 多波長異常分散 / 解像度: 1.451→56.08 Å / Cor.coef. Fo:Fc: 0.964 / Cor.coef. Fo:Fc free: 0.95 / SU B: 1.796 / SU ML: 0.033 / 交差検証法: THROUGHOUT / ESU R: 0.068 / ESU R Free: 0.062 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.19157
1278
5.1 %
RANDOM
Rwork
0.16105
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obs
0.16258
23794
95.83 %
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all
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26079
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: BABINET MODEL WITH MASK