登録情報 | データベース: PDB / ID: 2p39 |
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タイトル | Crystal structure of human FGF23 |
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要素 | Fibroblast growth factor 23 |
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キーワード | SIGNALING PROTEIN / atypical beta-trefoil fold |
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機能・相同性 | 機能・相同性情報
positive regulation of vitamin D 24-hydroxylase activity / type 1 fibroblast growth factor receptor binding / FGFRL1 modulation of FGFR1 signaling / regulation of phosphate transport / FGFR1c and Klotho ligand binding and activation / negative regulation of hormone secretion / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / response to sodium phosphate / vitamin D catabolic process / negative regulation of bone mineralization ...positive regulation of vitamin D 24-hydroxylase activity / type 1 fibroblast growth factor receptor binding / FGFRL1 modulation of FGFR1 signaling / regulation of phosphate transport / FGFR1c and Klotho ligand binding and activation / negative regulation of hormone secretion / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / response to sodium phosphate / vitamin D catabolic process / negative regulation of bone mineralization / phosphate ion homeostasis / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / Phospholipase C-mediated cascade; FGFR3 / intracellular phosphate ion homeostasis / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / FGFR4 ligand binding and activation / Phospholipase C-mediated cascade; FGFR2 / Phospholipase C-mediated cascade; FGFR4 / cellular response to vitamin D / Signaling by activated point mutants of FGFR1 / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / cellular response to leptin stimulus / cellular response to interleukin-6 / cellular response to parathyroid hormone stimulus / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR4 / PI-3K cascade:FGFR1 / response to magnesium ion / PI3K Cascade / fibroblast growth factor receptor signaling pathway / negative regulation of osteoblast differentiation / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / calcium ion homeostasis / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR3 signaling / FRS-mediated FGFR2 signaling / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / FRS-mediated FGFR1 signaling / neurogenesis / Signaling by FGFR2 in disease / ERK1 and ERK2 cascade / Signaling by FGFR1 in disease / regulation of cell migration / Post-translational protein phosphorylation / Negative regulation of FGFR3 signaling / growth factor activity / Negative regulation of FGFR2 signaling / Negative regulation of FGFR4 signaling / Negative regulation of FGFR1 signaling / Golgi lumen / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / RAF/MAP kinase cascade / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of ERK1 and ERK2 cascade / positive regulation of MAPK cascade / endoplasmic reticulum lumen / positive regulation of cell population proliferation / positive regulation of DNA-templated transcription / extracellular space / extracellular region / cytoplasm類似検索 - 分子機能 Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Mainly Beta類似検索 - ドメイン・相同性 sucrose octasulfate / Fibroblast growth factor 23類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
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データ登録者 | Mohammadi, M. |
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引用 | ジャーナル: Mol.Cell.Biol. / 年: 2007 タイトル: Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. 著者: Goetz, R. / Beenken, A. / Ibrahimi, O.A. / Kalinina, J. / Olsen, S.K. / Eliseenkova, A.V. / Xu, C. / Neubert, T.A. / Zhang, F. / Linhardt, R.J. / Yu, X. / White, K.E. / Inagaki, T. / Kliewer, ...著者: Goetz, R. / Beenken, A. / Ibrahimi, O.A. / Kalinina, J. / Olsen, S.K. / Eliseenkova, A.V. / Xu, C. / Neubert, T.A. / Zhang, F. / Linhardt, R.J. / Yu, X. / White, K.E. / Inagaki, T. / Kliewer, S.A. / Yamamoto, M. / Kurosu, H. / Ogawa, Y. / Kuro-O, M. / Lanske, B. / Razzaque, M.S. / Mohammadi, M. |
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履歴 | 登録 | 2007年3月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2007年4月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Non-polymer description / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / struct_conn / struct_conn_type / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年8月30日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 2.2 | 2024年10月30日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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