登録情報 | データベース: PDB / ID: 2nd0 |
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タイトル | Solution NMR structures of BRD4 ET domain with LANA peptide |
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要素 | - Bromodomain-containing protein 4
- LANA
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キーワード | TRANSCRIPTION/VIRAL PROTEIN / TRANSCRIPTION / VIRAL PROTEIN / TRANSCRIPTION-VIRAL PROTEIN complex |
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機能・相同性 | 機能・相同性情報
symbiont-mediated suppression of host NF-kappaB cascade / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / nucleosome binding / positive regulation of T-helper 17 cell lineage commitment / viral life cycle / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity ...symbiont-mediated suppression of host NF-kappaB cascade / RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / nucleosome binding / positive regulation of T-helper 17 cell lineage commitment / viral life cycle / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / host cell nucleus / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus類似検索 - 分子機能 Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #220 / : / Protein LANA1-like, DNA-binding domain / Epstein Barr virus nuclear antigen-1, DNA-binding domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. ...Substrate Binding Domain Of Dnak; Chain:A; Domain 2 - #220 / : / Protein LANA1-like, DNA-binding domain / Epstein Barr virus nuclear antigen-1, DNA-binding domain superfamily / Substrate Binding Domain Of Dnak; Chain:A; Domain 2 / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 LANA / Bromodomain-containing protein 4 / Protein LANA1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_virus.gif) Human herpesvirus 8 (ヘルペスウイルス) |
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手法 | 溶液NMR / torsion angle dynamics, distance geometry |
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Model details | lowest energy, model1 |
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データ登録者 | Zeng, L. / Zhou, M. |
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引用 | ジャーナル: Structure / 年: 2016 タイトル: Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. 著者: Zhang, Q. / Zeng, L. / Shen, C. / Ju, Y. / Konuma, T. / Zhao, C. / Vakoc, C.R. / Zhou, M.M. |
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履歴 | 登録 | 2016年4月18日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2016年6月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年7月20日 | Group: Database references |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model |
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