- PDB-2mv6: Solution structure of the transmembrane domain and the juxta-memb... -
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Basic information
Entry
Database: PDB / ID: 2mv6
Title
Solution structure of the transmembrane domain and the juxta-membrane domain of the Erythropoietin Receptor in micelles
Components
Erythropoietin receptor
Keywords
MEMBRANE PROTEIN / Micelles / Transmembrane domain / Erythropoietin receptor
Function / homology
Function and homology information
erythropoietin receptor activity / erythropoietin-mediated signaling pathway / Signaling by Erythropoietin / Erythropoietin activates STAT5 / Erythropoietin activates Phospholipase C gamma (PLCG) / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / hemopoiesis / decidualization / Erythropoietin activates RAS / brain development ...erythropoietin receptor activity / erythropoietin-mediated signaling pathway / Signaling by Erythropoietin / Erythropoietin activates STAT5 / Erythropoietin activates Phospholipase C gamma (PLCG) / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / hemopoiesis / decidualization / Erythropoietin activates RAS / brain development / cytokine-mediated signaling pathway / heart development / nuclear speck / external side of plasma membrane / positive regulation of cell population proliferation / signal transduction / extracellular region / identical protein binding / plasma membrane Similarity search - Function
Erythropoietin receptor / Long hematopoietin receptor, single chain, conserved site / Long hematopoietin receptor, single chain family signature. / Growth hormone/erythropoietin receptor, ligand binding / Erythropoietin receptor, ligand binding / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin-like fold Similarity search - Domain/homology
Method: simulated annealing / Software ordinal: 1 Details: simulated annealing was started with 3500 and cool down to 100 K with 15,000 steps. Structure was energy minimized with powell energy minimization.
NMR constraints
NOE constraints total: 260 / NOE intraresidue total count: 78 / NOE long range total count: 0 / NOE medium range total count: 42 / NOE sequential total count: 140 / Hydrogen bond constraints total count: 17 / Protein chi angle constraints total count: 0 / Protein other angle constraints total count: 0 / Protein phi angle constraints total count: 40 / Protein psi angle constraints total count: 40
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 50 / Conformers submitted total number: 20
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