- PDB-2l7s: Determination of the three-dimensional structure of adrenomedulli... -
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基本情報
登録情報
データベース: PDB / ID: 2l7s
タイトル
Determination of the three-dimensional structure of adrenomedullin, a first step towards the analysis of its interactions with receptors and small molecules
要素
Adrenomedullin
キーワード
HORMONE / pre-pro-adrenomedullin
機能・相同性
機能・相同性情報
adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / vascular associated smooth muscle cell development / neuron projection regeneration / adrenomedullin receptor signaling pathway / spongiotrophoblast layer development / Calcitonin-like ligand receptors / branching involved in labyrinthine layer morphogenesis / regulation of the force of heart contraction / positive regulation of vasculogenesis ...adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / vascular associated smooth muscle cell development / neuron projection regeneration / adrenomedullin receptor signaling pathway / spongiotrophoblast layer development / Calcitonin-like ligand receptors / branching involved in labyrinthine layer morphogenesis / regulation of the force of heart contraction / positive regulation of vasculogenesis / regulation of systemic arterial blood pressure / developmental growth / G protein-coupled receptor internalization / regulation of urine volume / negative regulation of vascular permeability / negative regulation of vasoconstriction / positive regulation of heart rate / response to starvation / odontogenesis of dentin-containing tooth / androgen metabolic process / vasculogenesis / animal organ regeneration / response to glucocorticoid / cAMP-mediated signaling / neural tube closure / female pregnancy / adenylate cyclase-activating G protein-coupled receptor signaling pathway / response to insulin / hormone activity / receptor internalization / positive regulation of angiogenesis / heart development / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / response to lipopolysaccharide / cell population proliferation / response to hypoxia / inflammatory response / positive regulation of apoptotic process / negative regulation of cell population proliferation / signaling receptor binding / positive regulation of cell population proliferation / signal transduction / extracellular space / extracellular region / cytoplasm 類似検索 - 分子機能
NOE constraints total: 2338 / NOE intraresidue total count: 957 / NOE long range total count: 27 / NOE medium range total count: 235 / NOE sequential total count: 695
代表構造
選択基準: lowest energy
NMRアンサンブル
コンフォーマー選択の基準: structures with the lowest energy 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 20