- PDB-2l6a: Three-dimensional structure of the N-terminal effector PYRIN doma... -
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Basic information
Entry
Database: PDB / ID: 2l6a
Title
Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12
Components
NACHT, LRR and PYD domains-containing protein 12
Keywords
SIGNALING PROTEIN / NLRP12 / PYRIN / death domain
Function / homology
Function and homology information
regulation of interleukin-18 production / negative regulation of Toll signaling pathway / positive regulation of MHC class I biosynthetic process / regulation of cysteine-type endopeptidase activity involved in apoptotic process / dendritic cell migration / negative regulation of protein autophosphorylation / negative regulation of interleukin-1 production / negative regulation of non-canonical NF-kappaB signal transduction / regulation of canonical NF-kappaB signal transduction / negative regulation of cytokine production ...regulation of interleukin-18 production / negative regulation of Toll signaling pathway / positive regulation of MHC class I biosynthetic process / regulation of cysteine-type endopeptidase activity involved in apoptotic process / dendritic cell migration / negative regulation of protein autophosphorylation / negative regulation of interleukin-1 production / negative regulation of non-canonical NF-kappaB signal transduction / regulation of canonical NF-kappaB signal transduction / negative regulation of cytokine production / negative regulation of NF-kappaB transcription factor activity / cellular response to cytokine stimulus / negative regulation of interleukin-6 production / cysteine-type endopeptidase activator activity involved in apoptotic process / negative regulation of signal transduction / negative regulation of canonical NF-kappaB signal transduction / ERK1 and ERK2 cascade / positive regulation of interleukin-1 beta production / negative regulation of inflammatory response / positive regulation of non-canonical NF-kappaB signal transduction / negative regulation of ERK1 and ERK2 cascade / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of inflammatory response / protein-macromolecule adaptor activity / SARS-CoV-2 activates/modulates innate and adaptive immune responses / signal transduction / ATP binding / cytoplasm / cytosol Similarity search - Function
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