follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / positive regulation of dendritic cell cytokine production / phosphoinositide phospholipase C / antifungal innate immune response / positive regulation of interleukin-23 production / phospholipid catabolic process / cellular response to lectin / phosphorylation-dependent protein binding ...follicular B cell differentiation / inositol trisphosphate biosynthetic process / regulation of calcineurin-NFAT signaling cascade / positive regulation of dendritic cell cytokine production / phosphoinositide phospholipase C / antifungal innate immune response / positive regulation of interleukin-23 production / phospholipid catabolic process / cellular response to lectin / phosphorylation-dependent protein binding / positive regulation of cell cycle G1/S phase transition / positive regulation of I-kappaB phosphorylation / response to yeast / intracellular vesicle / phosphatidylinositol metabolic process / Toll Like Receptor 4 (TLR4) Cascade / cell activation / positive regulation of neuroinflammatory response / positive regulation of phagocytosis, engulfment / phosphatidylinositol phospholipase C activity / Erythropoietin activates Phospholipase C gamma (PLCG) / phospholipase C activity / programmed cell death / phosphatidylinositol biosynthetic process / macrophage activation involved in immune response / cellular response to lipid / negative regulation of programmed cell death / regulation of canonical NF-kappaB signal transduction / positive regulation of macrophage cytokine production / positive regulation of reactive oxygen species biosynthetic process / positive regulation of NLRP3 inflammasome complex assembly / toll-like receptor signaling pathway / positive regulation of epithelial cell migration / Dectin-2 family / Synthesis of IP3 and IP4 in the cytosol / stimulatory C-type lectin receptor signaling pathway / Fc-epsilon receptor signaling pathway / phosphatidylinositol-mediated signaling / positive regulation of receptor internalization / positive regulation of interleukin-10 production / regulation of lipid metabolic process / Generation of second messenger molecules / response to axon injury / positive regulation of type I interferon production / Role of phospholipids in phagocytosis / release of sequestered calcium ion into cytosol / lipopolysaccharide-mediated signaling pathway / GPVI-mediated activation cascade / cellular response to calcium ion / positive regulation of interleukin-12 production / positive regulation of calcium-mediated signaling / positive regulation of interleukin-2 production / phosphotyrosine residue binding / FCERI mediated Ca+2 mobilization / B cell differentiation / FCGR3A-mediated IL10 synthesis / protein tyrosine kinase binding / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / FCERI mediated MAPK activation / B cell receptor signaling pathway / ruffle membrane / calcium-mediated signaling / positive regulation of DNA-binding transcription factor activity / platelet activation / CLEC7A (Dectin-1) signaling / Wnt signaling pathway / positive regulation of interleukin-6 production / Signaling by CSF1 (M-CSF) in myeloid cells / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of tumor necrosis factor production / DAP12 signaling / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / scaffold protein binding / Potential therapeutics for SARS / positive regulation of MAPK cascade / intracellular signal transduction / membrane raft / positive regulation of gene expression / protein kinase binding / perinuclear region of cytoplasm / extracellular exosome / plasma membrane / cytoplasm / cytosol Similarity search - Function
Name: CNS / Developer: Brunger A. T. et.al. / Classification: refinement
Refinement
Method: simulated annealing / Software ordinal: 1 Details: Ab initio simulated annealing protocol within the CNS program, with PARALLHDGv5.3 force field and PROLSQ non-bonded energy function. This protocol adopts a mixture of Cartesian molecular ...Details: Ab initio simulated annealing protocol within the CNS program, with PARALLHDGv5.3 force field and PROLSQ non-bonded energy function. This protocol adopts a mixture of Cartesian molecular dynamics and torsion angle dynamics simulated annealing.
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: 20 structures for lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 20
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