登録情報 データベース : PDB / ID : 2jvy 構造の表示 ダウンロードとリンクタイトル Solution Structure of the EDA-ID-related C417F mutant of human NEMO zinc finger 要素NF-kappa-B essential modulator 詳細 キーワード METAL BINDING PROTEIN / CCHC classical zinc finger / CCHF mutant zinc finger / EDA-ID C417F mutant of NEMO zinc finger / beta-beta-alpha fold / Coiled coil / Cytoplasm / Disease mutation / Ectodermal dysplasia / Host-virus interaction / Nucleus / Transcription / Transcription regulation機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / RIP-mediated NFkB activation via ZBP1 / positive regulation of ubiquitin-dependent protein catabolic process ... IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / RIP-mediated NFkB activation via ZBP1 / positive regulation of ubiquitin-dependent protein catabolic process / SUMOylation of immune response proteins / anoikis / K63-linked polyubiquitin modification-dependent protein binding / positive regulation of T cell receptor signaling pathway / TRAF6 mediated NF-kB activation / positive regulation of macroautophagy / polyubiquitin modification-dependent protein binding / canonical NF-kappaB signal transduction / signaling adaptor activity / ubiquitin ligase complex / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / MAP3K8 (TPL2)-dependent MAPK1/3 activation / TICAM1, RIP1-mediated IKK complex recruitment / IKK complex recruitment mediated by RIP1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / TNFR1-induced NF-kappa-B signaling pathway / Regulation of NF-kappa B signaling / activated TAK1 mediates p38 MAPK activation / Activation of NF-kappaB in B cells / Regulation of TNFR1 signaling / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / response to virus / PKR-mediated signaling / mitotic spindle / CLEC7A (Dectin-1) signaling / spindle pole / FCERI mediated NF-kB activation / Interleukin-1 signaling / Ovarian tumor domain proteases / Downstream TCR signaling / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / positive regulation of canonical NF-kappaB signal transduction / ER-Phagosome pathway / protein-containing complex assembly / Ub-specific processing proteases / defense response to bacterium / inflammatory response / immune response / protein domain specific binding / protein heterodimerization activity / innate immune response / DNA damage response / ubiquitin protein ligase binding / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / protein-containing complex / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 : / C2H2 type zinc-finger / NF-kappa-B essential modulator NEMO, N-terminal / NF-kappa-B essential modulator NEMO / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator 類似検索 - ドメイン・相同性手法 溶液NMR / torsion angle dynamics 詳細データ登録者 Cordier, F. / Vinolo, E. / Veron, M. / Delepierre, M. / Agou, F. 引用ジャーナル : J.Mol.Biol. / 年 : 2008タイトル : Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation.著者 : Cordier, F. / Vinolo, E. / Veron, M. / Delepierre, M. / Agou, F. 履歴 登録 2007年9月28日 登録サイト : BMRB / 処理サイト : RCSB改定 1.0 2008年3月18日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2020年2月19日 Group : Database references / Derived calculations / Otherカテゴリ : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _struct_ref_seq_dif.details改定 1.3 2021年10月20日 Group : Database references / Derived calculations / カテゴリ : database_2 / struct_ref_seq_dif / struct_siteItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.4 2024年5月8日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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