Entry | Database: PDB / ID: 2jkv |
---|
Title | Structure of human Phosphogluconate Dehydrogenase in complex with NADPH at 2.53A |
---|
Components | 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING |
---|
Keywords | OXIDOREDUCTASE / PHOSPHOGLUCONATE / NADP / NADPH / PENTOSE SHUNT / DEHYDROGENASE |
---|
Function / homology | Function and homology information
D-gluconate catabolic process / phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) / phosphogluconate dehydrogenase (decarboxylating) activity / pentose biosynthetic process / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / pentose-phosphate shunt / NFE2L2 regulates pentose phosphate pathway genes / NADP binding / extracellular exosome ...D-gluconate catabolic process / phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) / phosphogluconate dehydrogenase (decarboxylating) activity / pentose biosynthetic process / Pentose phosphate pathway / pentose-phosphate shunt, oxidative branch / pentose-phosphate shunt / NFE2L2 regulates pentose phosphate pathway genes / NADP binding / extracellular exosome / nucleus / cytosolSimilarity search - Function 6-Phosphogluconate Dehydrogenase, domain 3 / 6-phosphogluconate-binding site / 6-phosphogluconate dehydrogenase signature. / 6-phosphogluconate dehydrogenase, decarboxylating / 6-phosphogluconate dehydrogenase, C-terminal / 6-phosphogluconate dehydrogenase / 6-phosphogluconate dehydrogenase, C-terminal domain / 6-phosphogluconate dehydrogenase, C-terminal domain / 6-phosphogluconate dehydrogenase, NADP-binding / NAD binding domain of 6-phosphogluconate dehydrogenase ...6-Phosphogluconate Dehydrogenase, domain 3 / 6-phosphogluconate-binding site / 6-phosphogluconate dehydrogenase signature. / 6-phosphogluconate dehydrogenase, decarboxylating / 6-phosphogluconate dehydrogenase, C-terminal / 6-phosphogluconate dehydrogenase / 6-phosphogluconate dehydrogenase, C-terminal domain / 6-phosphogluconate dehydrogenase, C-terminal domain / 6-phosphogluconate dehydrogenase, NADP-binding / NAD binding domain of 6-phosphogluconate dehydrogenase / N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 / N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 / 6-phosphogluconate dehydrogenase, domain 2 / 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Up-down Bundle / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | HOMO SAPIENS (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.532 Å |
---|
Authors | Pilka, E.S. / Kavanagh, K.L. / von Delft, F. / Muniz, J.R.C. / Murray, J. / Picaud, S. / Guo, K. / Edwards, A. / Arrowsmith, C.H. / Weigelt, J. ...Pilka, E.S. / Kavanagh, K.L. / von Delft, F. / Muniz, J.R.C. / Murray, J. / Picaud, S. / Guo, K. / Edwards, A. / Arrowsmith, C.H. / Weigelt, J. / Bountra, C. / Oppermann, U. |
---|
Citation | Journal: To be Published Title: Structure of Human Phosphogluconate Dehydrogenase in Complex with Nadph at 2.53A Authors: Ng, S.S. / von Delft, F. / Pilka, E.S. / Kavanagh, K.L. / McDonough, M.A. / Savitsky, P. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Sundstrom, M. / Schofield, C.J. / Oppermann, U. |
---|
History | Deposition | Sep 1, 2008 | Deposition site: PDBE / Processing site: PDBE |
---|
Revision 1.0 | Sep 1, 2009 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jan 14, 2015 | Group: Atomic model / Database references ...Atomic model / Database references / Derived calculations / Non-polymer description / Other / Refinement description / Structure summary / Version format compliance |
---|
Revision 1.2 | Jan 24, 2018 | Group: Database references / Category: citation_author / Item: _citation_author.name |
---|
Revision 1.3 | Feb 21, 2018 | Group: Database references / Category: citation_author / Item: _citation_author.name |
---|
Revision 1.4 | Dec 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|