[English] 日本語
Yorodumi- PDB-2j0f: Structural basis for non-competitive product inhibition in human ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2j0f | ||||||
---|---|---|---|---|---|---|---|
Title | Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design | ||||||
Components | THYMIDINE PHOSPHORYLASE | ||||||
Keywords | TRANSFERASE / HTP / CHEMOTAXIS / POLYMORPHISM / DISEASE MUTATION / GLYCOSYLTRANSFERASE / ANGIOGENESIS / GROWTH FACTOR / DIFFERENTIATION / DEVELOPMENTAL PROTEIN / HUMAN THYMIDINE PHOSPHORYLASE | ||||||
Function / homology | Function and homology information regulation of gastric motility / thymidine phosphorylase / dTMP catabolic process / pyrimidine nucleoside metabolic process / regulation of transmission of nerve impulse / pyrimidine-nucleoside phosphorylase activity / thymidine phosphorylase activity / pyrimidine nucleobase metabolic process / 1,4-alpha-oligoglucan phosphorylase activity / Pyrimidine catabolism ...regulation of gastric motility / thymidine phosphorylase / dTMP catabolic process / pyrimidine nucleoside metabolic process / regulation of transmission of nerve impulse / pyrimidine-nucleoside phosphorylase activity / thymidine phosphorylase activity / pyrimidine nucleobase metabolic process / 1,4-alpha-oligoglucan phosphorylase activity / Pyrimidine catabolism / Pyrimidine salvage / AMP catabolic process / mitochondrial genome maintenance / regulation of myelination / growth factor activity / chemotaxis / angiogenesis / cell differentiation / protein homodimerization activity / cytosol Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.31 Å | ||||||
Authors | El Omari, K. / Bronckaers, A. / Liekens, S. / Perez-Perez, M.J. / Balzarini, J. / Stammers, D.K. | ||||||
Citation | Journal: Biochem.J. / Year: 2006 Title: Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design. Authors: El Omari, K. / Bronckaers, A. / Liekens, S. / Perez-Perez, M. / Balzarini, J. / Stammers, D.K. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 2j0f.cif.gz | 330.3 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb2j0f.ent.gz | 270.5 KB | Display | PDB format |
PDBx/mmJSON format | 2j0f.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2j0f_validation.pdf.gz | 485.8 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 2j0f_full_validation.pdf.gz | 543 KB | Display | |
Data in XML | 2j0f_validation.xml.gz | 67.2 KB | Display | |
Data in CIF | 2j0f_validation.cif.gz | 92.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/j0/2j0f ftp://data.pdbj.org/pub/pdb/validation_reports/j0/2j0f | HTTPS FTP |
-Related structure data
Related structure data | 1uouS S: Starting model for refinement |
---|---|
Similar structure data |
-Links
-Assembly
Deposited unit |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
2 |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Unit cell |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1 / Refine code: 1
|