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- PDB-2j0f: Structural basis for non-competitive product inhibition in human ... -
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Open data
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Basic information
Entry | Database: PDB / ID: 2j0f | ||||||
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Title | Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design | ||||||
![]() | THYMIDINE PHOSPHORYLASE | ||||||
![]() | TRANSFERASE / HTP / CHEMOTAXIS / POLYMORPHISM / DISEASE MUTATION / GLYCOSYLTRANSFERASE / ANGIOGENESIS / GROWTH FACTOR / DIFFERENTIATION / DEVELOPMENTAL PROTEIN / HUMAN THYMIDINE PHOSPHORYLASE | ||||||
Function / homology | ![]() regulation of gastric motility / thymidine phosphorylase / dTMP catabolic process / pyrimidine nucleoside metabolic process / regulation of transmission of nerve impulse / pyrimidine-nucleoside phosphorylase activity / thymidine phosphorylase activity / pyrimidine nucleobase metabolic process / 1,4-alpha-oligoglucan phosphorylase activity / Pyrimidine catabolism ...regulation of gastric motility / thymidine phosphorylase / dTMP catabolic process / pyrimidine nucleoside metabolic process / regulation of transmission of nerve impulse / pyrimidine-nucleoside phosphorylase activity / thymidine phosphorylase activity / pyrimidine nucleobase metabolic process / 1,4-alpha-oligoglucan phosphorylase activity / Pyrimidine catabolism / Pyrimidine salvage / AMP catabolic process / mitochondrial genome maintenance / regulation of myelination / growth factor activity / chemotaxis / angiogenesis / cell differentiation / protein homodimerization activity / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | El Omari, K. / Bronckaers, A. / Liekens, S. / Perez-Perez, M.J. / Balzarini, J. / Stammers, D.K. | ||||||
![]() | ![]() Title: Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design. Authors: El Omari, K. / Bronckaers, A. / Liekens, S. / Perez-Perez, M. / Balzarini, J. / Stammers, D.K. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 330.3 KB | Display | ![]() |
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PDB format | ![]() | 270.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 485.8 KB | Display | ![]() |
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Full document | ![]() | 543 KB | Display | |
Data in XML | ![]() | 67.2 KB | Display | |
Data in CIF | ![]() | 92.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1uouS S: Starting model for refinement |
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Similar structure data |
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Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1 / Refine code: 1
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