- PDB-2hd4: Crystal structure of proteinase K inhibited by a lactoferrin octa... -
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IDまたはキーワード:
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基本情報
登録情報
データベース: PDB / ID: 2hd4
タイトル
Crystal structure of proteinase K inhibited by a lactoferrin octapeptide Gly-Asp-Glu-Gln-Gly-Glu-Asn-Lys at 2.15 A resolution
要素
8-mer Peptide from Lactotransferrin
Proteinase K
キーワード
HYDROLASE / proteinase K / complex / peptide complex / LACTOFERRIN FRAGMENT
機能・相同性
機能・相同性情報
negative regulation by host of viral process / membrane destabilizing activity / Mtb iron assimilation by chelation / phagocytic vesicle lumen / positive regulation of toll-like receptor 4 signaling pathway / Metal sequestration by antimicrobial proteins / negative regulation of viral process / negative regulation of cysteine-type endopeptidase activity / negative regulation of tumor necrosis factor (ligand) superfamily member 11 production / negative regulation of single-species biofilm formation in or on host organism ...negative regulation by host of viral process / membrane destabilizing activity / Mtb iron assimilation by chelation / phagocytic vesicle lumen / positive regulation of toll-like receptor 4 signaling pathway / Metal sequestration by antimicrobial proteins / negative regulation of viral process / negative regulation of cysteine-type endopeptidase activity / negative regulation of tumor necrosis factor (ligand) superfamily member 11 production / negative regulation of single-species biofilm formation in or on host organism / positive regulation of bone mineralization involved in bone maturation / negative regulation of lipopolysaccharide-mediated signaling pathway / specific granule / negative regulation of osteoclast development / antifungal humoral response / positive regulation of chondrocyte proliferation / negative regulation of ATP-dependent activity / regulation of tumor necrosis factor production / peptidase K / bone morphogenesis / Antimicrobial peptides / cysteine-type endopeptidase inhibitor activity / negative regulation of viral genome replication / positive regulation of osteoblast proliferation / humoral immune response / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; セリンエンドペプチターゼ / positive regulation of osteoblast differentiation / regulation of cytokine production / protein serine/threonine kinase activator activity / ossification / innate immune response in mucosa / secretory granule / lipopolysaccharide binding / positive regulation of protein serine/threonine kinase activity / recycling endosome / specific granule lumen / antimicrobial humoral immune response mediated by antimicrobial peptide / tertiary granule lumen / positive regulation of NF-kappaB transcription factor activity / heparin binding / iron ion transport / antibacterial humoral response / positive regulation of canonical NF-kappaB signal transduction / defense response to Gram-negative bacterium / killing of cells of another organism / early endosome / iron ion binding / Amyloid fiber formation / serine-type endopeptidase activity / calcium ion binding / Neutrophil degranulation / negative regulation of apoptotic process / cell surface / protein-containing complex / proteolysis / DNA binding / extracellular space / extracellular exosome / extracellular region / nucleus / metal ion binding / plasma membrane / cytoplasm 類似検索 - 分子機能
ProteinaseK / Tritirachium alkaline proteinase / Endopeptidase K
分子量: 28958.791 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Engyodontium album (菌類) / 参照: UniProt: P06873, peptidase K
#2: タンパク質・ペプチド
8-merPeptidefromLactotransferrin
分子量: 876.846 Da / 分子数: 1 / 由来タイプ: 合成 詳細: THE SEQUENCE OF THE PEPTIDE IS NATURALLY FOUND IN HOMO SAPIENS (HUMAN).THIS PEPTIEDE WAS TRAPPED DURUNG ITS DIGESTION BY PROTEINASE K. 参照: UniProt: Q8TCD2, UniProt: P02788*PLUS, 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; セリンエンドペプチターゼ
解像度: 2.15→20 Å / Cor.coef. Fo:Fc: 0.946 / Cor.coef. Fo:Fc free: 0.937 / SU B: 4.441 / SU ML: 0.118 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.29 / ESU R Free: 0.19 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.2024
729
5 %
RANDOM
Rwork
0.17066
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all
0.17003
14493
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obs
0.17242
13764
99.77 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK