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Yorodumi- PDB-2f74: Murine MHC class I H-2Db in complex with human b2-microglobulin a... -
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-Basic information
Entry | Database: PDB / ID: 2f74 | ||||||
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Title | Murine MHC class I H-2Db in complex with human b2-microglobulin and LCMV-derived immunodminant peptide gp33 | ||||||
Components |
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Keywords | IMMUNE SYSTEM / MURINE MHC / LCMV / RECEPTOR BINDING / beta2-microglobulin | ||||||
Function / homology | Function and homology information antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / beta-2-microglobulin binding / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / peptide binding / Nef mediated downregulation of MHC class I complex cell surface expression / negative regulation of receptor binding / DAP12 interactions ...antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / beta-2-microglobulin binding / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / peptide binding / Nef mediated downregulation of MHC class I complex cell surface expression / negative regulation of receptor binding / DAP12 interactions / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / cellular response to iron ion / Endosomal/Vacuolar pathway / lumenal side of endoplasmic reticulum membrane / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / ER to Golgi transport vesicle membrane / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / positive regulation of receptor-mediated endocytosis / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / specific granule lumen / recycling endosome membrane / phagocytic vesicle membrane / peptide antigen binding / positive regulation of cellular senescence / negative regulation of epithelial cell proliferation / antigen processing and presentation of exogenous peptide antigen via MHC class II / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / positive regulation of immune response / Modulation by Mtb of host immune system / positive regulation of T cell activation / sensory perception of smell / negative regulation of neuron projection development / positive regulation of protein binding / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / early endosome membrane / late endosome membrane / iron ion transport / ER-Phagosome pathway / T cell differentiation in thymus / protein refolding / protein homotetramerization / intracellular iron ion homeostasis / amyloid fibril formation / learning or memory / immune response / Amyloid fiber formation / Golgi membrane / endoplasmic reticulum lumen / external side of plasma membrane / lysosomal membrane / focal adhesion / signaling receptor binding / Neutrophil degranulation / protein-containing complex binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.7 Å | ||||||
Authors | Achour, A. / Michaelsson, J. / Harris, R.A. / Ljunggren, H.G. / Karre, K. / Schneider, G. / Sandalova, T. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 2006 Title: Structural Basis of the Differential Stability and Receptor Specificity of H-2D(b) in Complex with Murine versus Human beta(2)-Microglobulin. Authors: Achour, A. / Harris, R.A. / Ljunggren, H.G. / Schneider, G. / Sandalova, T. #1: Journal: Immunity / Year: 2002 Title: Structural Basis for LCMV Immune Evasion: Subversion of H-2D b and H-2Kb Presentation of gp33 Revealed by Comparative Crystal Structure Analyses. Authors: Achour, A. / Michaelsson, J. / Harris, R.A. / Odeberg, J. / Grufman, P. / Sandberg, J.K. / Levitsky, V. / Kaerre, K. / Sandalova, T. / Schneider, G. #2: Journal: J.Immunol. / Year: 2004 Title: Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition. Authors: Velloso, L.M. / Michaelson, J. / Ljunggren, H.G. / Schneider, G. / Achour, A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2f74.cif.gz | 169.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2f74.ent.gz | 134 KB | Display | PDB format |
PDBx/mmJSON format | 2f74.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 2f74_validation.pdf.gz | 473.6 KB | Display | wwPDB validaton report |
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Full document | 2f74_full_validation.pdf.gz | 498.4 KB | Display | |
Data in XML | 2f74_validation.xml.gz | 31.5 KB | Display | |
Data in CIF | 2f74_validation.cif.gz | 42.9 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/f7/2f74 ftp://data.pdbj.org/pub/pdb/validation_reports/f7/2f74 | HTTPS FTP |
-Related structure data
Related structure data | 1s7uS S: Starting model for refinement |
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Similar structure data |
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-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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