- PDB-2cso: Solution structure of the DEP domain of human pleckstrin -
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Basic information
Entry
Database: PDB / ID: 2cso
Title
Solution structure of the DEP domain of human pleckstrin
Components
Pleckstrin
Keywords
SIGNALING PROTEIN / DEP domain / Pleckstrin / Platelet p47 protein / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI
Function / homology
Function and homology information
positive regulation of inositol-polyphosphate 5-phosphatase activity / protein secretion by platelet / phospholipase C-inhibiting G protein-coupled receptor signaling pathway / regulation of cell diameter / thrombin-activated receptor signaling pathway / negative regulation of inositol phosphate biosynthetic process / negative regulation of calcium-mediated signaling / positive regulation of actin filament depolymerization / protein kinase C signaling / platelet degranulation ...positive regulation of inositol-polyphosphate 5-phosphatase activity / protein secretion by platelet / phospholipase C-inhibiting G protein-coupled receptor signaling pathway / regulation of cell diameter / thrombin-activated receptor signaling pathway / negative regulation of inositol phosphate biosynthetic process / negative regulation of calcium-mediated signaling / positive regulation of actin filament depolymerization / protein kinase C signaling / platelet degranulation / negative regulation of G protein-coupled receptor signaling pathway / phosphatidylinositol metabolic process / positive regulation of integrin activation / positive regulation of actin filament bundle assembly / cell projection organization / ruffle organization / phosphatidylinositol-3,4-bisphosphate binding / positive regulation of platelet activation / vesicle docking involved in exocytosis / cortical actin cytoskeleton organization / hematopoietic progenitor cell differentiation / integrin-mediated signaling pathway / protein kinase C binding / platelet aggregation / ruffle membrane / Platelet degranulation / actin cytoskeleton organization / protein homodimerization activity / extracellular region / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function
Pleckstrin, DEP domain / : / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain ...Pleckstrin, DEP domain / : / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / PH-like domain superfamily / Arc Repressor Mutant, subunit A / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Conformer selection criteria: target function, structures with the lowest energy, structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20
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