Entry Database : PDB / ID : 2ckn Structure visualization Downloads & linksTitle NMR Structure of the First Ig Module of mouse FGFR1 ComponentsBASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 Details Keywords TRANSFERASE / KINASE / HEPARIN-BINDING / NUCLEOTIDE-BINDING / IMMUNOGLOBULIN DOMAIN / ALTERNATICE SPLICING / ATP-BINDING / GLYCOPROTEIN / RECEPTOR / TYROSINE-PROTEIN KINASEFunction / homology Function and homology informationFunction Domain/homology Component
motogenic signaling involved in postnatal olfactory bulb interneuron migration / FGFR1c and Klotho ligand binding and activation / Phospholipase C-mediated cascade: FGFR1 / regulation of phosphorus metabolic process / FGFR1b ligand binding and activation / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / SHC-mediated cascade:FGFR1 / PI-3K cascade:FGFR1 / Signal transduction by L1 ... motogenic signaling involved in postnatal olfactory bulb interneuron migration / FGFR1c and Klotho ligand binding and activation / Phospholipase C-mediated cascade: FGFR1 / regulation of phosphorus metabolic process / FGFR1b ligand binding and activation / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / SHC-mediated cascade:FGFR1 / PI-3K cascade:FGFR1 / Signal transduction by L1 / FRS-mediated FGFR1 signaling / PI3K Cascade / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / Negative regulation of FGFR1 signaling / vasculogenesis involved in coronary vascular morphogenesis / orbitofrontal cortex development / negative regulation of fibroblast growth factor production / positive regulation of mitotic cell cycle DNA replication / regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of hepatic stellate cell activation / vitamin D3 metabolic process / RAF/MAP kinase cascade / regulation of phosphate transport / regulation of lateral mesodermal cell fate specification / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / PIP3 activates AKT signaling / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / multicellular organism development / receptor-receptor interaction / regulation of sensory perception of pain / fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development / auditory receptor cell development / ventricular zone neuroblast division / mesenchymal cell differentiation / positive regulation of parathyroid hormone secretion / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / ear development / paraxial mesoderm development / regulation of stem cell proliferation / fibroblast growth factor receptor activity / branching involved in salivary gland morphogenesis / organ induction / lung-associated mesenchyme development / positive regulation of kinase activity / positive regulation of fibroblast migration / outer ear morphogenesis / middle ear morphogenesis / embryonic limb morphogenesis / blood vessel morphogenesis / ureteric bud development / positive regulation of vascular endothelial cell proliferation / positive regulation of mesenchymal cell proliferation / midbrain development / inner ear morphogenesis / generation of neurons / stem cell population maintenance / fibroblast growth factor binding / central nervous system neuron development / plasma membrane => GO:0005886 / positive regulation of blood vessel endothelial cell migration / epithelial to mesenchymal transition / negative regulation of osteoblast differentiation / fibroblast growth factor receptor signaling pathway / chondrocyte differentiation / : / positive regulation of cell cycle / salivary gland morphogenesis / cell maturation / positive regulation of cardiac muscle cell proliferation / cell adhesion molecule binding / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of neuron differentiation / transmembrane receptor protein tyrosine kinase activity / SH2 domain binding / positive regulation of cell differentiation / sensory perception of sound / positive regulation of MAP kinase activity / lung development / brain development / receptor protein-tyrosine kinase / positive regulation of neuron projection development / positive regulation of inflammatory response / peptidyl-tyrosine phosphorylation / neuron projection development / heparin binding / regulation of cell population proliferation / cytoplasmic vesicle / regulation of gene expression / protein tyrosine kinase activity / angiogenesis / in utero embryonic development / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / negative regulation of gene expression / signaling receptor binding / positive regulation of cell population proliferation / protein-containing complex binding / perinuclear region of cytoplasm Similarity search - Function : / : / Fibroblast growth factor receptor 1, catalytic domain / Fibroblast growth factor receptor family / Immunoglobulin / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type ... : / : / Fibroblast growth factor receptor 1, catalytic domain / Fibroblast growth factor receptor family / Immunoglobulin / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)Method SOLUTION NMR DetailsAuthors Kiselyov, V.V. / Bock, E. / Berezin, V. / Poulsen, F.M. CitationJournal : Protein Sci. / Year : 2006Title : NMR Structure of the First Ig Module of Mouse Fgfr1.Authors : Kiselyov, V.V. / Bock, E. / Berezin, V. / Poulsen, F.M. History Deposition Apr 20, 2006 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 31, 2006 Provider : repository / Type : Initial releaseRevision 1.1 Apr 19, 2017 Group : OtherRevision 1.2 Jan 15, 2020 Group : Other / Category : pdbx_database_status / Item : _pdbx_database_status.status_code_cs
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