Entry Database : PDB / ID : 2bmb Structure visualization Downloads & linksTitle X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Saccharomyces cerevisiae ComponentsFOLIC ACID SYNTHESIS PROTEIN FOL1 Details Keywords TRANSFERASE / FOLATE BIOSYNTHESIS / LIGASE / MULTIFUNCTIONAL ENZYMEFunction / homology Function and homology informationFunction Domain/homology Component
dihydroneopterin aldolase / dihydroneopterin aldolase activity / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity / dihydropteroate synthase activity / folic acid biosynthetic process / mitochondrial envelope / tetrahydrofolate biosynthetic process / mitochondrial membrane ... dihydroneopterin aldolase / dihydroneopterin aldolase activity / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase / dihydropteroate synthase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity / dihydropteroate synthase activity / folic acid biosynthetic process / mitochondrial envelope / tetrahydrofolate biosynthetic process / mitochondrial membrane / kinase activity / mitochondrion / ATP binding / metal ion binding / cytoplasm Similarity search - Function Folic acid synthesis protein FOL1 / Dihydroneopterin aldolase/epimerase domain / Dihydroneopterin aldolase / Dihydroneopterin aldolase / 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK / GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase / Dihydropteroate synthase signature 1. / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily ... Folic acid synthesis protein FOL1 / Dihydroneopterin aldolase/epimerase domain / Dihydroneopterin aldolase / Dihydroneopterin aldolase / 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK / GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase / Dihydropteroate synthase signature 1. / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK / 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK superfamily / 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) / Dihydropteroate synthase domain / Dihydropteroate synthase signature 2. / Dihydropteroate synthase-like / Pterin-binding domain / Pterin binding enzyme / Pterin-binding domain profile. / Dihydropteroate synthase-like / Alpha-Beta Plaits / TIM Barrel / Alpha-Beta Barrel / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species SACCHAROMYCES CEREVISIAE (brewer's yeast)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Lawrence, M.C. / Iliades, P. / Fernley, R.T. / Berglez, J. / Pilling, P.A. / Macreadie, I.G. CitationJournal : J.Mol.Biol. / Year : 2005Title : The Three-Dimensional Structure of the Bifunctional 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase/Dihydropteroate Synthase of Saccharomyces CerevisiaeAuthors : Lawrence, M.C. / Iliades, P. / Fernley, R.T. / Berglez, J. / Pilling, P.A. / Macreadie, I.G. History Deposition Mar 11, 2005 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 17, 2006 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Jul 5, 2017 Group : Data collection / Category : diffrn_source / Item : _diffrn_source.typeRevision 1.4 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
Show all Show less Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.