- PDB-2acm: Solution structure of the SEA domain of human mucin 1 (MUC1) -
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基本情報
登録情報
データベース: PDB / ID: 2acm
タイトル
Solution structure of the SEA domain of human mucin 1 (MUC1)
要素
(Mucin-1) x 2
キーワード
STRUCTURAL PROTEIN / auto-catalytic proteolysis
機能・相同性
機能・相同性情報
Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / negative regulation of cell adhesion mediated by integrin / negative regulation of transcription by competitive promoter binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Dectin-2 family / DNA damage response, signal transduction by p53 class mediator ...Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / negative regulation of cell adhesion mediated by integrin / negative regulation of transcription by competitive promoter binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Dectin-2 family / DNA damage response, signal transduction by p53 class mediator / localization / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / transcription coregulator activity / Golgi lumen / p53 binding / Interleukin-4 and Interleukin-13 signaling / vesicle / apical plasma membrane / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular exosome / nucleus / plasma membrane 類似検索 - 分子機能
手法: simulated annealing / ソフトェア番号: 1 詳細: Deposited coordinates are based on 1238 non-redundant NOE distance restraints, 180 dihedral angle restraints and 42 distance restraints for (21) hydrogen bonds
代表構造
選択基準: low energy
NMRアンサンブル
コンフォーマー選択の基準: structures with acceptable covalent geometry, structures with the least restraint violations 計算したコンフォーマーの数: 100 / 登録したコンフォーマーの数: 15