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- PDB-1ztn: INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES -

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Basic information

Entry
Database: PDB / ID: 1ztn
TitleINACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES
ComponentsPotassium voltage-gated channel subfamily C member 4
KeywordsTRANSPORT PROTEIN / POTASSIUM CHANNEL / INACTIVATION GATE
Function / homology
Function and homology information


delayed rectifier potassium channel activity / Voltage gated Potassium channels / neuronal cell body membrane / action potential / voltage-gated potassium channel activity / potassium channel activity / voltage-gated potassium channel complex / axon terminus / dendrite membrane / potassium ion transmembrane transport ...delayed rectifier potassium channel activity / Voltage gated Potassium channels / neuronal cell body membrane / action potential / voltage-gated potassium channel activity / potassium channel activity / voltage-gated potassium channel complex / axon terminus / dendrite membrane / potassium ion transmembrane transport / potassium ion transport / protein homooligomerization / presynaptic membrane / chemical synaptic transmission / postsynaptic membrane / metal ion binding / plasma membrane
Similarity search - Function
Potassium channel, voltage dependent, Kv3.4 / : / Potassium channel, voltage dependent, Kv3 / Shal-type voltage-gated potassium channels, N-terminal / Shal-type voltage-gated potassium channels, N-terminal / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain ...Potassium channel, voltage dependent, Kv3.4 / : / Potassium channel, voltage dependent, Kv3 / Shal-type voltage-gated potassium channels, N-terminal / Shal-type voltage-gated potassium channels, N-terminal / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily / SKP1/BTB/POZ domain superfamily / Ion transport domain / Ion transport protein
Similarity search - Domain/homology
Voltage-gated potassium channel KCNC4
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR / MD
AuthorsAntz, C. / Geyer, M. / Fakler, B. / Schott, M. / Frank, R. / Guy, H.R. / Ruppersberg, J.P. / Kalbitzer, H.R.
CitationJournal: Nature / Year: 1997
Title: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.
Authors: Antz, C. / Geyer, M. / Fakler, B. / Schott, M.K. / Guy, H.R. / Frank, R. / Ruppersberg, J.P. / Kalbitzer, H.R.
History
DepositionNov 15, 1996Processing site: BNL
Revision 1.0Jun 5, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 10, 2016Group: Database references
Revision 1.4May 1, 2024Group: Data collection / Database references / Other
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_nmr_software
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _pdbx_nmr_software.name

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: Potassium voltage-gated channel subfamily C member 4


Theoretical massNumber of molelcules
Total (without water)3,2811
Polymers3,2811
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)8 / 105TO BE GIVEN
Representative

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Components

#1: Protein/peptide Potassium voltage-gated channel subfamily C member 4 / KSHIIIC / Voltage-gated potassium channel subunit Kv3.4 / POTASSIUM CHANNEL PROTEIN RAW3


Mass: 3280.862 Da / Num. of mol.: 1 / Fragment: INACTIVATION GATE, N-terminal
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: KCNC4 / References: UniProt: Q03721

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR
NMR experiment
Conditions-IDExperiment-IDSolution-IDType
111NOESY
121COSY
131TOCSY
NMR detailsText: STRUCTURE DETERMINATION USING HOMONUCLEAR 1H NMR SPECTROSCOPY.

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Sample preparation

Sample conditionspH: 3.5 / Temperature: 283 K
Crystal grow
*PLUS
Method: other / Details: NMR

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NMR measurement

NMR spectrometerType: Bruker AMX500 / Manufacturer: Bruker / Model: AMX500 / Field strength: 500 MHz

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Processing

Software
NameClassification
X-PLORmodel building
XWINNMRmodel building
X-PLORrefinement
XWINNMRrefinement
X-PLORphasing
XWINNMRphasing
NMR software
NameVersionDeveloperClassification
X-PLORBRUNGERrefinement
XwinNMRstructure solution
AURELIA (BRUKER)(BRUKER)structure solution
RefinementMethod: MD / Software ordinal: 1
NMR ensembleConformer selection criteria: TO BE GIVEN / Conformers calculated total number: 105 / Conformers submitted total number: 8

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