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- PDB-1tcp: NMR STRUCTURE DETERMINATION OF TICK ANTICOAGULANT PEPTIDE (TAP) -

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Basic information

Entry
Database: PDB / ID: 1tcp
TitleNMR STRUCTURE DETERMINATION OF TICK ANTICOAGULANT PEPTIDE (TAP)
ComponentsTICK ANTICOAGULANT PEPTIDE
KeywordsBLOOD COAGULATION INHIBITOR / FACTOR XA SERINE PROTEASE INHIBITOR
Function / homologyPancreatic trypsin inhibitor Kunitz domain / Factor Xa Inhibitor / Pancreatic trypsin inhibitor Kunitz domain superfamily / serine-type endopeptidase inhibitor activity / Few Secondary Structures / Irregular / Tick anticoagulant peptide
Function and homology information
Biological speciesOrnithodoros moubata (arthropod)
MethodSOLUTION NMR
AuthorsBrunck, T.K. / Lim-Wilby, M.S.L.
Citation
Journal: Protein Sci. / Year: 1995
Title: NMR structure determination of tick anticoagulant peptide (TAP).
Authors: Lim-Wilby, M.S. / Hallenga, K. / de Maeyer, M. / Lasters, I. / Vlasuk, G.P. / Brunck, T.K.
#1: Journal: J.Mol.Biol. / Year: 1993
Title: Determination of Disulfide Bond Pairs and Stability in Recombinant Tick Anticoagulant Peptide
Authors: Sardana, M. / Sardana, V. / Rodkey, J. / Wood, T. / Ng, A. / Vlasuk, G.P. / Waxman, J.
#2: Journal: Science / Year: 1990
Title: Tick Anticoagulant Peptide (Tap) is a Novel Inhibitor of Blood Coagulation Factor Xa
Authors: Waxman, L. / Smith, D.E. / Arcuri, K.E. / Vlasuk, G.P.
History
DepositionOct 31, 1994Processing site: BNL
Revision 1.0Oct 31, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 1.4Nov 20, 2024Group: Data collection / Database references / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / pdbx_nmr_software
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name

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Structure viewerMolecule:
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Assembly

Deposited unit
A: TICK ANTICOAGULANT PEPTIDE


Theoretical massNumber of molelcules
Total (without water)6,9931
Polymers6,9931
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)10 / -
Representative

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Components

#1: Protein TICK ANTICOAGULANT PEPTIDE


Mass: 6992.614 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Ornithodoros moubata (arthropod) / Cell line: PICHIA PASTORIS / Organ: BLOOD / Production host: Pichia pastoris (fungus) / References: UniProt: P17726
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: Discover / Developer: BIOSYM / Classification: refinement
NMR ensembleConformers submitted total number: 10

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