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- PDB-1san: THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUT... -

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Entry
Database: PDB / ID: 1san
TitleTHE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN
ComponentsANTENNAPEDIA PROTEIN
KeywordsDNA BINDING PROTEIN / DNA-BINDING PROTEIN
Function / homology
Function and homology information


specification of segmental identity, antennal segment / specification of segmental identity, thorax / neuroblast development / muscle cell fate specification / lymph gland development / ventral cord development / midgut development / anterior/posterior axis specification / anterior/posterior pattern specification / regulation of neurogenesis ...specification of segmental identity, antennal segment / specification of segmental identity, thorax / neuroblast development / muscle cell fate specification / lymph gland development / ventral cord development / midgut development / anterior/posterior axis specification / anterior/posterior pattern specification / regulation of neurogenesis / heart development / sequence-specific DNA binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleus / cytoplasm
Similarity search - Function
Homeobox protein, antennapedia type / Homeobox protein, antennapedia type, conserved site / 'Homeobox' antennapedia-type protein signature. / : / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain ...Homeobox protein, antennapedia type / Homeobox protein, antennapedia type, conserved site / 'Homeobox' antennapedia-type protein signature. / : / Homeobox domain, metazoa / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly Alpha
Similarity search - Domain/homology
Homeotic protein antennapedia
Similarity search - Component
Biological speciesDrosophila melanogaster (fruit fly)
MethodSOLUTION NMR
AuthorsQian, Y.Q. / Resendez-Perez, D. / Gehring, W.J. / Wuthrich, K.
Citation
Journal: Proc.Natl.Acad.Sci.USA / Year: 1994
Title: The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.
Authors: Qian, Y.Q. / Resendez-Perez, D. / Gehring, W.J. / Wuthrich, K.
#1: Journal: J.Mol.Biol. / Year: 1991
Title: Structure Determination of the Antp(C39->S) Homeodomain from Nuclear Magnetic Resonance Data in Solution Using a Novel Strategy for the Structure Calculation with the Programs Diana, Caliba, Habas and Glomsa
Authors: Guntert, P. / Qian, Y.-Q. / Otting, G. / Muller, M. / Gehring, W.J. / Wuthrich, K.
#2: Journal: Cell(Cambridge,Mass.) / Year: 1989
Title: The Structure of the Antennapedia Homeodomain Determined by NMR Spectroscopy in Solution: Comparison with Prokaryotic Repressors
Authors: Qian, Y.-Q. / Billeter, M. / Otting, G. / Muller, M. / Gehring, W.J. / Wuthrich, K.
#3: Journal: J.Mol.Biol. / Year: 1990
Title: Determination of the Three-Dimensional Structure of the Antennapedia Homeodomain from Drosophila in Solution by 1H Nuclear Magnetic Resonance Spectroscopy
Authors: Billeter, M. / Qian, Y.-Q. / Otting, G. / Muller, M. / Gehring, W.J. / Wuthrich, K.
History
DepositionJan 7, 1994Processing site: BNL
Revision 1.0Apr 30, 1994Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Mar 2, 2022Group: Database references / Derived calculations ...Database references / Derived calculations / Other / Structure summary
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_keywords / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_keywords.text / _struct_ref_seq_dif.details
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Assembly

Deposited unit
A: ANTENNAPEDIA PROTEIN


Theoretical massNumber of molelcules
Total (without water)7,8751
Polymers7,8751
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein ANTENNAPEDIA PROTEIN


Mass: 7875.151 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Organ: FRUIT / Production host: Escherichia coli (E. coli) / References: UniProt: P02833

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

NMR softwareName: DIANA / Developer: GUNTERT,BRAUN,WUTHRICH / Classification: refinement
NMR ensembleConformers submitted total number: 20

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