- PDB-1otr: Solution Structure of a CUE-Ubiquitin Complex -
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基本情報
登録情報
データベース: PDB / ID: 1otr
タイトル
Solution Structure of a CUE-Ubiquitin Complex
要素
Ubiquitin
protein Cue2
キーワード
CELL CYCLE / PROTEIN-PROTEIN COMPLEX
機能・相同性
機能・相同性情報
: / : / : / : / : / : / Regulation of TP53 Degradation / Josephin domain DUBs / RAS processing / Regulation of PTEN localization ...: / : / : / : / : / : / Regulation of TP53 Degradation / Josephin domain DUBs / RAS processing / Regulation of PTEN localization / ER Quality Control Compartment (ERQC) / UCH proteinases / Pexophagy / Interleukin-1 signaling / Aggrephagy / nuclear-transcribed mRNA catabolic process, no-go decay / Peroxisomal protein import / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / ABC-family proteins mediated transport / Metalloprotease DUBs / Endosomal Sorting Complex Required For Transport (ESCRT) / E3 ubiquitin ligases ubiquitinate target proteins / Translesion Synthesis by POLH / Translesion synthesis by REV1 / Translesion synthesis by POLK / Translesion synthesis by POLI / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Termination of translesion DNA synthesis / Negative regulators of DDX58/IFIH1 signaling / Formation of the ternary complex, and subsequently, the 43S complex / Ribosomal scanning and start codon recognition / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / Formation of TC-NER Pre-Incision Complex / Major pathway of rRNA processing in the nucleolus and cytosol / Orc1 removal from chromatin / MAPK6/MAPK4 signaling / SRP-dependent cotranslational protein targeting to membrane / GTP hydrolysis and joining of the 60S ribosomal subunit / Gap-filling DNA repair synthesis and ligation in TC-NER / Formation of a pool of free 40S subunits / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Antigen processing: Ubiquitination & Proteasome degradation / L13a-mediated translational silencing of Ceruloplasmin expression / Dual incision in TC-NER / ribosomal large subunit export from nucleus / Ub-specific processing proteases / ubiquitin binding / ribosomal large subunit assembly / modification-dependent protein catabolic process / protein tag activity / ribosome biogenesis / endonuclease activity / cytosolic large ribosomal subunit / cytoplasmic translation / protein ubiquitination / structural constituent of ribosome / ubiquitin protein ligase binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
Ubiquitin-binding protein Cue2, CUE domain 1 / Ubiquitin-binding protein Cue2, CUE domain 2 / Smr domain superfamily / Small MutS-related domain / Smr domain / Smr domain profile. / CUE domain / Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) / Ubiquitin system component CUE / CUE domain profile. ...Ubiquitin-binding protein Cue2, CUE domain 1 / Ubiquitin-binding protein Cue2, CUE domain 2 / Smr domain superfamily / Small MutS-related domain / Smr domain / Smr domain profile. / CUE domain / Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs) / Ubiquitin system component CUE / CUE domain profile. / Ubiquitin-associated (UBA) domain / UBA-like superfamily / Ribosomal L40e family / Ribosomal_L40e / Ribosomal protein L40e / Ribosomal protein L40e superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Helicase, Ruva Protein; domain 3 / Ubiquitin domain signature. / Ubiquitin conserved site / Ubiquitin domain / Ubiquitin-like (UB roll) / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Roll / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性
Polyubiquitin / Ubiquitin-binding protein CUE2 / Ubiquitin-60S ribosomal protein L40 類似検索 - 構成要素
The submitted conformer models are the 20 structures with the lowest restraint energies, restraint violations, and RMS deviations from ideal covalent geometry
代表モデル
モデル #1
closest to the average
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要素
#1: タンパク質・ペプチド
proteinCue2 / HYPOTHETICAL 50.9 KD PROTEIN IN BUD2-MIF2 INTERGENIC REGION / hypothetical protein YKL090w
手法: torsion angle dynamics, simulated annealing / ソフトェア番号: 1 詳細: The structures are based on a total of 3328 distance restraints, including 3238 NOE-derived distance restraints [2560 unambiguous and 678 ambiguous restraints], 90 hydrogen bonding distance ...詳細: The structures are based on a total of 3328 distance restraints, including 3238 NOE-derived distance restraints [2560 unambiguous and 678 ambiguous restraints], 90 hydrogen bonding distance restraints, and 150 torsion angle restraints.
代表構造
選択基準: closest to the average
NMRアンサンブル
コンフォーマー選択の基準: The submitted conformer models are the 20 structures with the lowest restraint energies, restraint violations, and RMS deviations from ideal covalent geometry 計算したコンフォーマーの数: 80 / 登録したコンフォーマーの数: 20