登録情報 データベース : PDB / ID : 1ogs 構造の表示 ダウンロードとリンクタイトル human acid-beta-glucosidase 要素Glucosylceramidase 詳細 キーワード HYDROLASE / GAUCHER DISEASE / GLUCOSIDASE / GLUCOCEREBROSIDASE / CEREZYME HYDROLASE / GLYCOSIDASE / SPHINGOLIPID METABOLISM / GLYCOPROTE LYSOSOME / MEMBRANE / DISEASE MUTATI POLYMORPHISM / ALTERNATIVE INITIATION / PHARMACEUTICAL / ISRAEL STRUCTURAL PROTEOMICS CENTER / ISPC / STRUCTURAL GENOMICS機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
steryl-beta-glucosidase activity / positive regulation of neuronal action potential / beta-glucoside catabolic process / cerebellar Purkinje cell layer formation / termination of signal transduction / galactosylceramidase / galactosylceramidase activity / glucosylceramidase / scavenger receptor binding / lymphocyte migration ... steryl-beta-glucosidase activity / positive regulation of neuronal action potential / beta-glucoside catabolic process / cerebellar Purkinje cell layer formation / termination of signal transduction / galactosylceramidase / galactosylceramidase activity / glucosylceramidase / scavenger receptor binding / lymphocyte migration / glucosylceramide catabolic process / regulation of lysosomal protein catabolic process / response to thyroid hormone / glucosylceramidase activity / sphingosine biosynthetic process / autophagosome organization / microglial cell proliferation / lysosomal protein catabolic process / glucosyltransferase activity / regulation of TOR signaling / Glycosphingolipid catabolism / lipid storage / microglia differentiation / ceramide biosynthetic process / positive regulation of type 2 mitophagy / : / brain morphogenesis / response to pH / 加水分解酵素; 糖加水分解酵素; 配糖体結合加水分解酵素または糖加水分解酵素 / pyramidal neuron differentiation / negative regulation of protein metabolic process / 転移酵素; グリコシル基を移すもの; 六炭糖残基を移すもの / lysosome organization / neuromuscular process / response to dexamethasone / hematopoietic stem cell proliferation / response to testosterone / antigen processing and presentation / motor behavior / Association of TriC/CCT with target proteins during biosynthesis / negative regulation of interleukin-6 production / homeostasis of number of cells / regulation of macroautophagy / establishment of skin barrier / negative regulation of protein-containing complex assembly / cell maturation / negative regulation of MAPK cascade / mitophagy / cholesterol metabolic process / lysosomal lumen / cellular response to starvation / respiratory electron transport chain / determination of adult lifespan / trans-Golgi network / autophagy / negative regulation of inflammatory response / response to estrogen / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / cellular response to tumor necrosis factor / T cell differentiation in thymus / neuron apoptotic process / proteasome-mediated ubiquitin-dependent protein catabolic process / negative regulation of neuron apoptotic process / lysosome / signaling receptor binding / lysosomal membrane / endoplasmic reticulum / Golgi apparatus / extracellular exosome 類似検索 - 分子機能 Glycosyl hydrolase family 30, TIM-barrel domain / Glycosyl hydrolase family 30 TIM-barrel domain / Glycosyl hydrolase family 30, beta sandwich domain / Glycosyl hydrolase family 30 beta sandwich domain / Glycoside hydrolase family 30 / Golgi alpha-mannosidase II / Glycosidases / Glycoside hydrolase superfamily / TIM Barrel / Alpha-Beta Barrel ... Glycosyl hydrolase family 30, TIM-barrel domain / Glycosyl hydrolase family 30 TIM-barrel domain / Glycosyl hydrolase family 30, beta sandwich domain / Glycosyl hydrolase family 30 beta sandwich domain / Glycoside hydrolase family 30 / Golgi alpha-mannosidase II / Glycosidases / Glycoside hydrolase superfamily / TIM Barrel / Alpha-Beta Barrel / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 多波長異常分散 / 解像度 : 2 Å 詳細データ登録者 Dvir, H. / Harel, M. / McCarthy, A.A. / Toker, L. / Silman, I. / Futerman, A.H. / Sussman, J.L. 引用ジャーナル : Embo Rep. / 年 : 2003タイトル : X-Ray Structure of Human Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease著者 : Dvir, H. / Harel, M. / Mccarthy, A.A. / Toker, L. / Silman, I. / Futerman, A.H. / Sussman, J.L. 履歴 登録 2003年5月13日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2003年7月3日 Provider : repository / タイプ : Initial release改定 1.1 2012年1月25日 Group : Advisory / Atomic model ... Advisory / Atomic model / Derived calculations / Non-polymer description / Other / Refinement description / Version format compliance 改定 1.2 2019年10月16日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Experimental preparation / Other / Source and taxonomy / Structure summary カテゴリ : entity / entity_name_com ... entity / entity_name_com / entity_src_gen / exptl_crystal_grow / pdbx_database_status / pdbx_entity_src_syn / struct_conn / struct_ref / struct_ref_seq_dif Item : _entity.pdbx_description / _entity.pdbx_ec ... _entity.pdbx_description / _entity.pdbx_ec / _entity.src_method / _entity_name_com.name / _exptl_crystal_grow.method / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flag / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_seq_one_letter_code 改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_special_symmetry / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_special_symmetry.label_asym_id / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2024年11月20日 Group : Data collection / Database references / Structure summaryカテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AC" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AC" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL. THE SHEETS PRESENTED AS "BC" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.