+Open data
-Basic information
Entry | Database: PDB / ID: 1lcx | ||||||
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Title | NMR structure of HIV-1 gp41 659-671 13mer peptide | ||||||
Components | GP41 | ||||||
Keywords | VIRAL PROTEIN / gp41 / 3-10 helix / HIV-1 | ||||||
Function / homology | Function and homology information Dectin-2 family / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / virus-mediated perturbation of host defense response / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane ...Dectin-2 family / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / virus-mediated perturbation of host defense response / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / structural molecule activity / membrane Similarity search - Function | ||||||
Method | SOLUTION NMR / distance geometry | ||||||
Authors | Biron, Z. / Khare, S. / Samson, A.O. / Hayek, Y. / Naider, F. / Anglister, J. | ||||||
Citation | Journal: Biochemistry / Year: 2002 Title: A Monomeric 3(10)-Helix Is Formed in Water by a 13-Residue Peptide Representing the Neutralizing Determinant of HIV-1 on gp41. Authors: Biron, Z. / Khare, S. / Samson, A.O. / Hayek, Y. / Naider, F. / Anglister, J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1lcx.cif.gz | 99.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1lcx.ent.gz | 76.3 KB | Display | PDB format |
PDBx/mmJSON format | 1lcx.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lc/1lcx ftp://data.pdbj.org/pub/pdb/validation_reports/lc/1lcx | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 1617.820 Da / Num. of mol.: 1 / Fragment: Residues 659-671 / Source method: obtained synthetically Details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in HIV-1 virus. References: UniProt: P31872 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample conditions | Ionic strength: 0.1 M / pH: 7.7 / Pressure: 1 atm / Temperature: 277 K | |||||||||
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M | |||||||||||||||
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Radiation wavelength | Relative weight: 1 | |||||||||||||||
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: distance geometry / Software ordinal: 1 | ||||||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with acceptable covalent geometry,structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 25 |