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- PDB-1lcd: STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BAS... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1lcd | ||||||
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Title | STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | ||||||
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![]() | GENE REGULATION/DNA / GENE REGULATION-DNA complex | ||||||
Function / homology | ![]() DNA-binding transcription repressor activity / cis-regulatory region sequence-specific DNA binding / transcription cis-regulatory region binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / identical protein binding / cytosol Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Chuprina, V.P. / Rullmann, J.A.C. / Lamerichs, R.M.J.N. / Van Boom, J.H. / Boelens, R. / Kaptein, R. | ||||||
![]() | ![]() Title: Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. Authors: Chuprina, V.P. / Rullmann, J.A. / Lamerichs, R.M. / van Boom, J.H. / Boelens, R. / Kaptein, R. #1: ![]() Title: Assignment of the 1H-NMR Spectrum of a Lac Repressor Headpiece-Operator Complex in H2O and Identification of Noes. Consequences for Protein-DNA Interaction Authors: Lamerichs, R.M.J.N. / Boelens, R. / Van Der Marel, G.A. / Van Boom, J.H. / Kaptein, R. #2: ![]() Title: Two-Dimensional NMR Study of a Protein-DNA Complex. Lac Repressor Headpiece-Operator Interaction Authors: Kaptein, R. / Lamerichs, R.M.J.N. / Boelens, R. / Rullmann, J.A.C. #3: ![]() Title: 1H NMR Study of a Complex between the Lac Repressor Headpiece and a 22 Base Pair Symmetric Lac Operator Authors: Lamerichs, R.M.J.N. / Boelens, R. / Van Der Marel, G.A. / Van Boom, J.H. / Kaptein, R. / Buck, F. / Fera, B. / Rueterjans, H. #4: ![]() Title: NMR Based Docking Studies of Lac Repressor Headpiece on a Lac Operator Fragment Authors: Rullmann, J.A.C. / Boelens, R. / Kaptein, R. #5: ![]() Title: The Interaction of Lac Repressor Headpiece with its Operator: An NMR View Authors: Boelens, R. / Lamerichs, R.M.J.N. / Rullmann, J.A.C. / Van Boom, J.H. / Kaptein, R. #6: ![]() Title: Combined Procedure of Distance Geometry and Restrained Molecular Dynamics Techniques for Protein Structure Determination from Nuclear Magnetic Resonance Data: Application to the DNA Binding ...Title: Combined Procedure of Distance Geometry and Restrained Molecular Dynamics Techniques for Protein Structure Determination from Nuclear Magnetic Resonance Data: Application to the DNA Binding Domain of Lac Repressor from Escherichia Coli Authors: De Vlieg, J. / Scheek, R.M. / Van Gunsteren, W.F. / Berendsen, H.J.C. / Kaptein, R. / Thomason, J. #7: ![]() Title: A Two-Dimensional NMR Study of the Complex of Lac Repressor Headpiece with a 14 Base Pair Lac Operator Fragment Authors: Boelens, R. / Scheek, R.M. / Lamerichs, R.M.J.N. / De Vlieg, J. / Van Boom, J.H. / Kaptein, R. #8: ![]() Title: Complex of Lac Repressor Headpiece with a 14 Base Pair Lac Operator Fragment Studied by Two-Dimensional Nuclear Magnetic Resonance Authors: Boelens, R. / Scheek, R.M. / Van Boom, J.H. / Kaptein, R. #9: ![]() Title: Restrained Molecular Dynamics Procedure for Protein Tertiary Structure Determination from NMR Data: A Lac Repressor Headpiece Structure Based on Information on J-Coupling and from Presence and Absence of Noes Authors: De Vlieg, J. / Boelens, R. / Scheek, R.M. / Kaptein, R. / Van Gunsteren, W.F. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 82.7 KB | Display | ![]() |
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PDB format | ![]() | 54.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 374 KB | Display | ![]() |
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Full document | ![]() | 450.1 KB | Display | |
Data in XML | ![]() | 15.4 KB | Display | |
Data in CIF | ![]() | 20.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: DNA chain | Mass: 3413.246 Da / Num. of mol.: 1 / Source method: obtained synthetically |
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#2: DNA chain | Mass: 3293.174 Da / Num. of mol.: 1 / Source method: obtained synthetically |
#3: Protein | Mass: 5693.446 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() |
#4: Chemical | ChemComp-NA / |
#5: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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Processing
NMR ensemble | Conformers submitted total number: 3 |
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