登録情報 データベース : PDB / ID : 1k37 構造の表示 ダウンロードとリンクタイトル NMR Structure of human Epiregulin 要素Epiregulin 詳細 キーワード HORMONE/GROWTH FACTOR / EGF-like fold / HORMONE-GROWTH FACTOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
luteinizing hormone signaling pathway / ovarian cumulus expansion / ovulation / ERBB4-ERBB4 signaling pathway / negative regulation of smooth muscle cell differentiation / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-ERBB4 signaling pathway / primary follicle stage / ERBB2-EGFR signaling pathway ... luteinizing hormone signaling pathway / ovarian cumulus expansion / ovulation / ERBB4-ERBB4 signaling pathway / negative regulation of smooth muscle cell differentiation / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-ERBB4 signaling pathway / primary follicle stage / ERBB2-EGFR signaling pathway / ERBB2 Activates PTK6 Signaling / female meiotic nuclear division / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / PI3K events in ERBB4 signaling / Signaling by ERBB4 / ERBB2 Regulates Cell Motility / positive regulation of innate immune response / PI3K events in ERBB2 signaling / mRNA transcription / oocyte maturation / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / epidermal growth factor receptor binding / GAB1 signalosome / positive regulation of DNA replication / positive regulation of phosphorylation / positive regulation of cell division / Signaling by ERBB2 / keratinocyte proliferation / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / anatomical structure morphogenesis / positive regulation of protein kinase activity / GRB2 events in ERBB2 signaling / SHC1 events in ERBB2 signaling / Nuclear signaling by ERBB4 / keratinocyte differentiation / positive regulation of mitotic nuclear division / positive regulation of smooth muscle cell proliferation / EGFR downregulation / Signaling by ERBB2 TMD/JMD mutants / clathrin-coated endocytic vesicle membrane / positive regulation of cytokine production / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / animal organ morphogenesis / Downregulation of ERBB2 signaling / growth factor activity / wound healing / Constitutive Signaling by Aberrant PI3K in Cancer / response to peptide hormone / cytokine-mediated signaling pathway / positive regulation of fibroblast proliferation / positive regulation of interleukin-6 production / Cargo recognition for clathrin-mediated endocytosis / negative regulation of epithelial cell proliferation / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / cell-cell signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / angiogenesis / Extra-nuclear estrogen signaling / receptor ligand activity / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 Laminin / Laminin / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / distance geometry simulated annealing 詳細Model type details minimized average データ登録者 Sato, K. / Miura, K. / Tada, M. / Aizawa, T. / Miyamoto, K. / Kawano, K. 引用ジャーナル : Febs Lett. / 年 : 2003タイトル : Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity著者 : Sato, K. / Nakamura, T. / Mizuguchi, M. / Miura, K. / Tada, M. / Aizawa, T. / Gomi, T. / Miyamoto, K. / Kawano, K. 履歴 登録 2001年10月2日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2003年9月30日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月27日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2022年2月23日 Group : Database references / Derived calculationsカテゴリ : database_2 / pdbx_struct_assembly / pdbx_struct_oper_listItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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