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- PDB-1hth: The solution structure of cyclic human parathyroid hormone fragme... -

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Basic information

Entry
Database: PDB / ID: 1hth
TitleThe solution structure of cyclic human parathyroid hormone fragment 1-34, NMR, 10 structures
ComponentsCYCLIC PARATHYROID HORMONE
KeywordsHORMONE / HUMAN PARATHYROID HORMONE / CYCLIC / ORNITHINE / NORLEUCINE
Function / homology
Function and homology information


macromolecule biosynthetic process / parathyroid hormone receptor binding / type 1 parathyroid hormone receptor binding / negative regulation of bone mineralization involved in bone maturation / negative regulation of apoptotic process in bone marrow cell / positive regulation of osteoclast proliferation / response to parathyroid hormone / positive regulation of cell proliferation in bone marrow / hormone-mediated apoptotic signaling pathway / adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway ...macromolecule biosynthetic process / parathyroid hormone receptor binding / type 1 parathyroid hormone receptor binding / negative regulation of bone mineralization involved in bone maturation / negative regulation of apoptotic process in bone marrow cell / positive regulation of osteoclast proliferation / response to parathyroid hormone / positive regulation of cell proliferation in bone marrow / hormone-mediated apoptotic signaling pathway / adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway / positive regulation of signal transduction / magnesium ion homeostasis / response to fibroblast growth factor / cAMP metabolic process / phosphate ion homeostasis / Class B/2 (Secretin family receptors) / negative regulation of chondrocyte differentiation / response to vitamin D / peptide hormone receptor binding / bone mineralization / positive regulation of inositol phosphate biosynthetic process / positive regulation of glycogen biosynthetic process / response to cadmium ion / bone resorption / positive regulation of bone mineralization / Rho protein signal transduction / homeostasis of number of cells within a tissue / positive regulation of D-glucose import across plasma membrane / skeletal system development / hormone activity / response to lead ion / intracellular calcium ion homeostasis / cell-cell signaling / adenylate cyclase-activating G protein-coupled receptor signaling pathway / regulation of gene expression / transcription by RNA polymerase II / G alpha (s) signalling events / response to ethanol / response to xenobiotic stimulus / G protein-coupled receptor signaling pathway / receptor ligand activity / negative regulation of gene expression / positive regulation of gene expression / positive regulation of transcription by RNA polymerase II / : / extracellular region
Similarity search - Function
Parathyroid hormone / Parathyroid hormone/parathyroid hormone-related protein / Parathyroid hormone family / Parathyroid hormone family signature. / Parathyroid hormone
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR / SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS
AuthorsRoesch, P. / Seidel, G. / Schaefer, W. / Esswein, A. / Hofmann, E.
CitationJournal: Febs Lett. / Year: 1999
Title: The structure of human parathyroid hormone-related protein(1-34) in near-physiological solution.
Authors: Weidler, M. / Marx, U.C. / Seidel, G. / Schaefer, W. / Hoffmann, E. / Esswein, A. / Roesch, P.
History
DepositionApr 9, 1997Processing site: BNL
Revision 1.0Oct 15, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Non-polymer description / Version format compliance
Revision 1.3Nov 3, 2021Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / struct_conn / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: CYCLIC PARATHYROID HORMONE


Theoretical massNumber of molelcules
Total (without water)4,1171
Polymers4,1171
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)10 / 50ENERGY, AGREEMENT WITH EXPERIMENTAL DATA
Representative

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Components

#1: Protein/peptide CYCLIC PARATHYROID HORMONE


Mass: 4116.704 Da / Num. of mol.: 1 / Fragment: RESIDUES 1-34 / Mutation: M8NLE, K13ORN, S17E, M18NLE
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P01270

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 5 / Temperature: 298 K
Crystal grow
*PLUS
Method: other / Details: NMR

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NMR measurement

NMR spectrometerType: Bruker AMX600 / Manufacturer: Bruker / Model: AMX600 / Field strength: 600 MHz

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR software
NameVersionDeveloperClassification
X-PLOR3.1BRUNGERrefinement
NDEEstructure solution
X-PLORstructure solution
RefinementMethod: SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS / Software ordinal: 1
NMR ensembleConformer selection criteria: ENERGY, AGREEMENT WITH EXPERIMENTAL DATA
Conformers calculated total number: 50 / Conformers submitted total number: 10

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