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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1hio | ||||||
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タイトル | HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY | ||||||
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![]() | CHROMOSOMAL PROTEIN / HISTONE / NUCLEOSOME CORE | ||||||
機能・相同性 | ![]() PKMTs methylate histone lysines / HDMs demethylate histones / RMTs methylate histone arginines / SUMOylation of chromatin organization proteins / Nonhomologous End-Joining (NHEJ) / G2/M DNA damage checkpoint / Processing of DNA double-strand break ends / Condensation of Prophase Chromosomes / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Metalloprotease DUBs ...PKMTs methylate histone lysines / HDMs demethylate histones / RMTs methylate histone arginines / SUMOylation of chromatin organization proteins / Nonhomologous End-Joining (NHEJ) / G2/M DNA damage checkpoint / Processing of DNA double-strand break ends / Condensation of Prophase Chromosomes / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Metalloprotease DUBs / Interleukin-7 signaling / Chromatin modifying enzymes / UCH proteinases / Formation of the beta-catenin:TCF transactivating complex / PRC2 methylates histones and DNA / Oxidative Stress Induced Senescence / HDACs deacetylate histones / HATs acetylate histones / B-WICH complex positively regulates rRNA expression / Transcriptional regulation by small RNAs / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / Ub-specific processing proteases / Assembly of the ORC complex at the origin of replication / RNA Polymerase I Promoter Opening / RNA Polymerase I Promoter Escape / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Estrogen-dependent gene expression / Deposition of new CENPA-containing nucleosomes at the centromere / Factors involved in megakaryocyte development and platelet production / heterochromatin organization / nucleosomal DNA binding / structural constituent of chromatin / nucleosome / nucleosome assembly / gene expression / protein heterodimerization activity / chromatin binding / protein-containing complex binding / negative regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus 類似検索 - 分子機能 | ||||||
生物種 | ![]() ![]() | ||||||
手法 | ![]() | ||||||
![]() | Arents, G. / Moudrianakis, E.N. | ||||||
![]() | ![]() タイトル: The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix. 著者: Arents, G. / Burlingame, R.W. / Wang, B.C. / Love, W.E. / Moudrianakis, E.N. #1: ![]() タイトル: Spectropolarimetric Analysis of the Core Histone Octamer and its Subunits 著者: Godfrey, J.E. / Baxevanis, A.D. / Moudrianakis, E.N. #2: ![]() タイトル: Crystallographic Structure of the Octameric Histone Core of the Nucleosome at a Resolution of 3.3 A 著者: Burlingame, R.W. / Love, W.E. / Wang, B.C. / Hamlin, R. / Xuong, N.H. / Moudrianakis, E.N. #3: ![]() タイトル: Crystals of the Octameric Histone Core of the Nucleosome 著者: Burlingame, R.W. / Love, W.E. / Moudrianakis, E.N. #4: ![]() タイトル: Reversible Association of Calf Thymus Histones to Form the Symmetrical Octamer (H2Ah2Bh3H4)2: A Case of a Mixed-Associating System 著者: Godfrey, J.E. / Eickbush, T.H. / Moudrianakis, E.N. #5: ![]() タイトル: The Histone Core Complex: An Octamer Assembled by Two Sets of Protein-Protein Interactions 著者: Eickbush, T.H. / Moudrianakis, E.N. #6: ![]() タイトル: The Compaction of DNA Helices Into Either Continuous Supercoils or Folded-Fiber Rods and Toroids 著者: Eickbush, T.H. / Moudrianakis, E.N. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 23 KB | 表示 | ![]() |
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PDB形式 | ![]() | 11.5 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 293.1 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 293.1 KB | 表示 | |
XML形式データ | ![]() | 730 B | 表示 | |
CIF形式データ | ![]() | 4 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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1 | ![]()
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単位格子 |
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要素
#1: タンパク質 | 分子量: 10401.095 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) ![]() ![]() |
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#2: タンパク質 | 分子量: 9910.378 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) ![]() ![]() |
#3: タンパク質 | 分子量: 10776.571 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) ![]() ![]() |
#4: タンパク質 | 分子量: 8568.044 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) ![]() ![]() |
-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 5.29 Å3/Da / 溶媒含有率: 76.75 % 解説: THE ENTRY WAS SUBMITTED IN 1991, WITHOUT COMPLETE EXPERIMENTAL DETAILS. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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結晶化 | *PLUS pH: 7.5 / 手法: microdialysis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
放射 | 散乱光タイプ: x-ray |
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放射波長 | 相対比: 1 |
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解析
ソフトウェア | 名称: PROFFT / 分類: 精密化 | ||||||||||||
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精密化 | 解像度: 3.1→10 Å / σ(F): 2 詳細: THIS ENTRY WAS SUBMITTED IN 1991, WITHOUT COMPLETE REFINEMENT DETAILS. PLEASE NOTE THAT THE ORIGINAL COORDINATES SENT TO PDB IN 1991 ARE ALPHA CARBONS ONLY. THE FULL COORDINATES (AS OF ...詳細: THIS ENTRY WAS SUBMITTED IN 1991, WITHOUT COMPLETE REFINEMENT DETAILS. PLEASE NOTE THAT THE ORIGINAL COORDINATES SENT TO PDB IN 1991 ARE ALPHA CARBONS ONLY. THE FULL COORDINATES (AS OF 09/15/98) CAN BE FOUND AT THE URL HTTP://WWW.BIO.JHU.EDU/FACULTY/MOUDRIANAKIS/ MOUDRIANAKIS.HTML
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精密化ステップ | サイクル: LAST / 解像度: 3.1→10 Å
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拘束条件 | *PLUS
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