+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1gbr | ||||||
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タイトル | ORIENTATION OF PEPTIDE FRAGMENTS FROM SOS PROTEINS BOUND TO THE N-TERMINAL SH3 DOMAIN OF GRB2 DETERMINED BY NMR SPECTROSCOPY | ||||||
要素 |
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キーワード | SIGNAL TRANSDUCTION PROTEIN | ||||||
機能・相同性 | 機能・相同性情報 Signalling to RAS / Activated NTRK2 signals through FRS2 and FRS3 / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / MET activates PI3K/AKT signaling ...Signalling to RAS / Activated NTRK2 signals through FRS2 and FRS3 / SHC1 events in ERBB4 signaling / GRB2 events in ERBB2 signaling / EGFR Transactivation by Gastrin / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / SHC-mediated cascade:FGFR2 / MET activates PI3K/AKT signaling / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR4 / SHC-related events triggered by IGF1R / Signal regulatory protein family interactions / PI-3K cascade:FGFR1 / PI-3K cascade:FGFR2 / SOS-mediated signalling / FRS-mediated FGFR3 signaling / FRS-mediated FGFR4 signaling / MET activates RAS signaling / MET activates PTPN11 / Signaling by LTK / Costimulation by the CD28 family / FRS-mediated FGFR1 signaling / FRS-mediated FGFR2 signaling / PI3K events in ERBB2 signaling / Tie2 Signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / Interleukin-15 signaling / CD28 dependent Vav1 pathway / FLT3 Signaling / MET activates RAP1 and RAC1 / Signaling by CSF3 (G-CSF) / MET receptor recycling / NCAM signaling for neurite out-growth / Erythropoietin activates RAS / Regulation of KIT signaling / GAB1 signalosome / PI3K Cascade / Role of LAT2/NTAL/LAB on calcium mobilization / RHOU GTPase cycle / Negative regulation of FGFR3 signaling / Negative regulation of FGFR4 signaling / Downstream signal transduction / Negative regulation of FGFR1 signaling / Negative regulation of FGFR2 signaling / Spry regulation of FGF signaling / Negative regulation of MET activity / FCERI mediated MAPK activation / Insulin receptor signalling cascade / anatomical structure formation involved in morphogenesis / RHO GTPases Activate WASPs and WAVEs / NRAGE signals death through JNK / Signal attenuation / lymphocyte homeostasis / Signaling by SCF-KIT / EGFR downregulation / guanyl-nucleotide exchange factor adaptor activity / GRB2:SOS provides linkage to MAPK signaling for Integrins / RAC1 GTPase cycle / Grb2-EGFR complex / FCERI mediated Ca+2 mobilization / G alpha (12/13) signalling events / Interleukin receptor SHC signaling / RAF/MAP kinase cascade / branching involved in labyrinthine layer morphogenesis / PIP3 activates AKT signaling / regulation of pro-B cell differentiation / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of signaling by CBL / Regulation of actin dynamics for phagocytic cup formation / Cargo recognition for clathrin-mediated endocytosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Clathrin-mediated endocytosis / RET signaling / COP9 signalosome / neurotrophin TRKA receptor binding / transmembrane receptor protein tyrosine kinase adaptor activity / regulation of T cell differentiation in thymus / positive regulation of small GTPase mediated signal transduction / vesicle membrane / DAP12 signaling / positive regulation of actin filament polymerization / epidermal growth factor receptor binding / small GTPase-mediated signal transduction / regulation of T cell proliferation / ERBB2-ERBB3 signaling pathway / endodermal cell differentiation / B cell homeostasis / regulation of MAPK cascade / insulin receptor substrate binding / fibroblast growth factor receptor signaling pathway / signal transduction in response to DNA damage / Schwann cell development / phosphotyrosine residue binding / myelination / ephrin receptor binding / insulin-like growth factor receptor signaling pathway / guanyl-nucleotide exchange factor activity 類似検索 - 分子機能 | ||||||
生物種 | Mus musculus (ハツカネズミ) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Wittekind, M. / Mapelli, C. / Farmer, B.T. / Suen, K.-L. / Goldfarb, V. / Tsao, J. / Lavoie, T. / Barbacid, M. / Meyers, C.A. / Mueller, L. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1994 タイトル: Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy. 著者: Wittekind, M. / Mapelli, C. / Farmer 2nd., B.T. / Suen, K.L. / Goldfarb, V. / Tsao, J. / Lavoie, T. / Barbacid, M. / Meyers, C.A. / Mueller, L. #1: ジャーナル: Mol.Cell.Biol. / 年: 1993 タイトル: Molecular Cloning of the Mouse Grb2 Gene: Differential Interaction of the Grb2 Adaptor Protein with Epidermal Growth Factor and Nerve Growth Factor Receptors 著者: Suen, K.-L. / Bustelo, X.R. / Pawson, T. / Barbacid, M. #2: ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 1992 タイトル: Identification of Murine Homologues of the Drosophila Son of Sevenless Gene: Potential Activators of Ras 著者: Bowtell, D. / Fu, P. / Simon, M. / Senior, P. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1gbr.cif.gz | 819.3 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1gbr.ent.gz | 683.8 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1gbr.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 1gbr_validation.pdf.gz | 361.8 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 1gbr_full_validation.pdf.gz | 666.8 KB | 表示 | |
XML形式データ | 1gbr_validation.xml.gz | 49.5 KB | 表示 | |
CIF形式データ | 1gbr_validation.cif.gz | 81.9 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/gb/1gbr ftp://data.pdbj.org/pub/pdb/validation_reports/gb/1gbr | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 8454.495 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Mus musculus (ハツカネズミ) / 遺伝子: MOUSE GRB2 / プラスミド: PGTX-2T (PHARMACIA) / 生物種 (発現宿主): Escherichia coli / 発現宿主: Escherichia coli BL21 (大腸菌) / 株 (発現宿主): BL21 / 参照: UniProt: Q60631 |
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#2: タンパク質・ペプチド | 分子量: 1771.150 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Mus musculus (ハツカネズミ) / 参照: UniProt: Q02384 |
-実験情報
-実験
実験 | 手法: 溶液NMR |
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-解析
ソフトウェア |
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NMR software | 名称: X-PLOR / 開発者: BRUNGER / 分類: 精密化 | ||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 29 |