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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1fu2 | |||||||||
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タイトル | FIRST PROTEIN STRUCTURE DETERMINED FROM X-RAY POWDER DIFFRACTION DATA | |||||||||
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![]() | HORMONE/GROWTH FACTOR / POWDER DIFFRACTION / RIETVELD REFINEMENT / INSULIN / HORMONE-GROWTH FACTOR COMPLEX | |||||||||
機能・相同性 | ![]() negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / regulation of cellular amino acid metabolic process / positive regulation of nitric oxide mediated signal transduction / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / IRS activation / Insulin processing / regulation of protein secretion ...negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / regulation of cellular amino acid metabolic process / positive regulation of nitric oxide mediated signal transduction / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / IRS activation / Insulin processing / regulation of protein secretion / positive regulation of respiratory burst / positive regulation of peptide hormone secretion / Regulation of gene expression in beta cells / negative regulation of acute inflammatory response / alpha-beta T cell activation / negative regulation of respiratory burst involved in inflammatory response / positive regulation of dendritic spine maintenance / positive regulation of glycogen biosynthetic process / Synthesis, secretion, and deacylation of Ghrelin / negative regulation of protein secretion / regulation of protein localization to plasma membrane / fatty acid homeostasis / Signal attenuation / negative regulation of lipid catabolic process / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / negative regulation of gluconeogenesis / COPI-mediated anterograde transport / positive regulation of lipid biosynthetic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / negative regulation of reactive oxygen species biosynthetic process / positive regulation of insulin receptor signaling pathway / nitric oxide-cGMP-mediated signaling / transport vesicle / positive regulation of protein autophosphorylation / Insulin receptor recycling / neuron projection maintenance / NPAS4 regulates expression of target genes / positive regulation of protein metabolic process / positive regulation of brown fat cell differentiation / positive regulation of glycolytic process / activation of protein kinase B activity / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of mitotic nuclear division / Insulin receptor signalling cascade / positive regulation of nitric-oxide synthase activity / positive regulation of cytokine production / positive regulation of long-term synaptic potentiation / acute-phase response / Regulation of insulin secretion / endosome lumen / positive regulation of protein secretion / positive regulation of glucose import / negative regulation of proteolysis / positive regulation of cell differentiation / regulation of transmembrane transporter activity / insulin-like growth factor receptor binding / wound healing / insulin receptor binding / regulation of synaptic plasticity / negative regulation of protein catabolic process / hormone activity / cognition / positive regulation of neuron projection development / positive regulation of protein localization to nucleus / Golgi lumen / vasodilation / glucose metabolic process / regulation of protein localization / insulin receptor signaling pathway / cell-cell signaling / glucose homeostasis / positive regulation of NF-kappaB transcription factor activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of cell growth / secretory granule lumen / protease binding / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell migration / G protein-coupled receptor signaling pathway / Amyloid fiber formation / endoplasmic reticulum lumen / Golgi membrane / negative regulation of gene expression / positive regulation of cell population proliferation / positive regulation of gene expression / regulation of DNA-templated transcription / extracellular space / extracellular region / identical protein binding 類似検索 - 分子機能 | |||||||||
手法 | 粉末回折 / ![]() | |||||||||
![]() | Von Dreele, R.B. / Stephens, P.W. / Blessing, R.H. / Smith, G.D. | |||||||||
![]() | ![]() タイトル: The first protein crystal structure determined from high-resolution X-ray powder diffraction data: a variant of T3R3 human insulin-zinc complex produced by grinding. 著者: Von Dreele, R.B. / Stephens, P.W. / Smith, G.D. / Blessing, R.H. #1: ![]() タイトル: Combined Rietveld and Stereochemical Restraint Refinement of a Protein Crystal Structure 著者: Von Dreele, R.B. #2: ![]() タイトル: Crystallographic Evidence for Dual Coordinate Aroun in the T3R3 Human Insulin Hexamer 著者: Smith, G.D. / Ciszak, E. | |||||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 42.1 KB | 表示 | ![]() |
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PDB形式 | ![]() | 32.4 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 385.8 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 421.3 KB | 表示 | |
XML形式データ | ![]() | 10.7 KB | 表示 | |
CIF形式データ | ![]() | 15.1 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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Components on special symmetry positions |
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要素
#1: タンパク質・ペプチド | 分子量: 2383.698 Da / 分子数: 4 / 断片: A CHAIN OF T3R3 VARIANT / 由来タイプ: 合成 / 詳細: This sequence occurs naturally in humans / 参照: UniProt: P01308 #2: タンパク質・ペプチド | 分子量: 3433.953 Da / 分子数: 4 / 断片: B CHAIN OF T3R3 VARIANT / 由来タイプ: 合成 / 詳細: This sequence occurs naturally in humans / 参照: UniProt: P01308 #3: 化合物 | ChemComp-ZN / #4: 化合物 | ChemComp-CL / #5: 化合物 | |
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-実験情報
-実験
実験 | 手法: 粉末回折 / 使用した結晶の数: 1 |
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試料調製
結晶 | マシュー密度: 1.99 Å3/Da / 溶媒含有率: 38.34 % |
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結晶化 | *PLUS 手法: other / 詳細: ground into powder |
-データ収集
回折 | 平均測定温度: 300 K |
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放射光源 | 由来: ![]() ![]() ![]() |
検出器 | タイプ: OTHER / 検出器: DIFFRACTOMETER / 日付: 1999年10月15日 |
放射 | プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1.401107 Å / 相対比: 1 |