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- PDB-1etf: REV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, M... -

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Basic information

Entry
Database: PDB / ID: 1etf
TitleREV RESPONSE ELEMENT (RRE) RNA COMPLEXED WITH REV PEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Components
  • REV PEPTIDE
  • REV RESPONSE ELEMENT RNA
KeywordsViral protein/RNA / COMPLEX (RNA-PEPTIDE) / EXPORT REGULATOR / MRNA SPLICING / TRANSCRIPTION REGULATION / Viral protein-RNA COMPLEX
Function / homology
Function and homology information


host cell nucleolus / mRNA transport / host cell cytoplasm / DNA-binding transcription factor activity / RNA binding
Similarity search - Function
Anti-repression trans-activator protein, REV protein / REV protein (anti-repression trans-activator protein)
Similarity search - Domain/homology
RNA / RNA (> 10) / Protein Rev
Similarity search - Component
Biological speciesHuman immunodeficiency virus 1
MethodSOLUTION NMR
AuthorsBattiste, J.L. / Mao, H. / Rao, N.S. / Tan, R. / Muhandiram, D.R. / Kay, L.E. / Frankel, A.D. / Willamson, J.R.
Citation
Journal: Science / Year: 1996
Title: Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex.
Authors: Battiste, J.L. / Mao, H. / Rao, N.S. / Tan, R. / Muhandiram, D.R. / Kay, L.E. / Frankel, A.D. / Williamson, J.R.
#1: Journal: J.Biomol.NMR / Year: 1995
Title: Assignment and Modeling of the Rev Response Element RNA Bound to a Rev Peptide Using 13C-Heteronuclear NMR
Authors: Battiste, J.L. / Tan, R. / Frankel, A.D. / Williamson, J.R.
#2: Journal: Biochemistry / Year: 1994
Title: Binding of an HIV Rev Peptide to Rev Responsive Element RNA Induces Formation of Purine-Purine Base Pairs
Authors: Battiste, J.L. / Tan, R. / Frankel, A.D. / Williamson, J.R.
#3: Journal: Cell(Cambridge,Mass.) / Year: 1993
Title: RNA Recognition by an Isolated Alpha Helix
Authors: Tan, R. / Chen, L. / Buettner, J.A. / Hudson, D. / Frankel, A.D.
History
DepositionAug 28, 1996Processing site: BNL
Revision 1.0Mar 12, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 3, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_ref_seq_dif.details

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: REV RESPONSE ELEMENT RNA
B: REV PEPTIDE


Theoretical massNumber of molelcules
Total (without water)14,0442
Polymers14,0442
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representative

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Components

#1: RNA chain REV RESPONSE ELEMENT RNA


Mass: 11039.639 Da / Num. of mol.: 1 / Source method: obtained synthetically
#2: Protein/peptide REV PEPTIDE


Mass: 3004.411 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Human immunodeficiency virus 1 / Genus: Lentivirus / Production host: Escherichia coli (E. coli) / References: UniProt: P05866

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: INSIGHT/DISCOVER / Developer: BIOSYM / Classification: refinement
NMR ensembleConformers submitted total number: 1

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