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- PDB-1d0r: SOLUTION STRUCTURE OF GLUCAGON-LIKE PEPTIDE-1-(7-36)-AMIDE IN TRI... -
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Basic information
Entry | Database: PDB / ID: 1d0r | ||||||
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Title | SOLUTION STRUCTURE OF GLUCAGON-LIKE PEPTIDE-1-(7-36)-AMIDE IN TRIFLUOROETHANOL/WATER | ||||||
![]() | GLUCAGON-LIKE PEPTIDE-1-(7-36)-AMIDE | ||||||
![]() | HORMONE/GROWTH FACTOR / SYNTHETIC HORMONE / HORMONE-GROWTH FACTOR COMPLEX | ||||||
Function / homology | ![]() glucagon receptor binding / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / cellular response to glucagon stimulus / positive regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of insulin secretion / Synthesis, secretion, and deacylation of Ghrelin / positive regulation of gluconeogenesis / protein kinase A signaling ...glucagon receptor binding / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / cellular response to glucagon stimulus / positive regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of insulin secretion / Synthesis, secretion, and deacylation of Ghrelin / positive regulation of gluconeogenesis / protein kinase A signaling / positive regulation of peptidyl-threonine phosphorylation / response to activity / gluconeogenesis / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / Glucagon signaling in metabolic regulation / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Glucagon-type ligand receptors / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / positive regulation of peptidyl-serine phosphorylation / glucose homeostasis / G alpha (s) signalling events / G alpha (q) signalling events / secretory granule lumen / positive regulation of ERK1 and ERK2 cascade / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / signaling receptor binding / negative regulation of apoptotic process / extracellular space / extracellular region / identical protein binding / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / DISTANCE GEOMETRY, SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS | ||||||
![]() | Chang, X. / Keller, D. / Bjorn, S. / Led, J.J. | ||||||
![]() | Journal: MAGN.RESON.CHEM. / Year: 2001 Title: Structure and Folding of Glucagon-like Peptide-1-(7-36)-amide in Trifluoroethanol Studied by NMR Authors: Chang, X. / Keller, D. / Bjorn, S. / Led, J.J. #1: ![]() Title: NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer Authors: Chang, X. / Keller, D. / O'Donoghue, S.I. / Led, J.J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 186.4 KB | Display | ![]() |
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PDB format | ![]() | 151.9 KB | Display | ![]() |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 3302.648 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: RECOMBINANT FORM / Source: (gene. exp.) ![]() ![]() ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||
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NMR experiment |
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NMR details | Text: THIS STRUCTURE WAS DETERMINED USING STANDARD 2D HOMONUCLEAR TECHNIQUES. |
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Sample preparation
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Sample conditions | pH: 2.5 / Pressure: AMBIENT / Temperature: 300 K | ||||||
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: DISTANCE GEOMETRY, SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS Software ordinal: 1 Details: THE STRUCTURES ARE BASED ON 280 NOE-DERIVED DISTANCE CONSTRAINTS, AND 24 DISTANCE RESTRAINTS FROM HYDROGEN BONDS | ||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 40 / Conformers submitted total number: 20 | ||||||||||||
NMR ensemble rms | Atom type: all backbone atoms / Bond angle rms dev: 3.3 ° / Chain range begin: A / Chain range end: A Coord average rmsd method: THE AVERAGE OF THE RMSD TO THE MEAN OF THE 20 NMR CONFORMERS AS DESCRIBED IN REFERENCE JRNL IS 2.92 ANGSTROMS FOR THE N, C AND CA BACKBONE ATOMS Covalent bond rms dev: 0.0144 Å / Improper torsion angle rms dev: 0.33 ° / Residue range begin: 1 / Residue range end: 30 |