登録情報 | データベース: PDB / ID: 1cqq |
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タイトル | TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR |
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要素 | TYPE 2 RHINOVIRUS 3C PROTEASE |
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キーワード | HYDROLASE / VIRAL PROTEIN |
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機能・相同性 | 機能・相同性情報
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase ...symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / symbiont-mediated suppression of host gene expression / DNA replication / RNA helicase activity / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding類似検索 - 分子機能 Poliovirus 3A protein-like / Poliovirus 3A protein like / Picornavirus 2B protein / Poliovirus core protein 3a, soluble domain / Picornavirus 2B protein / Peptidase C3, picornavirus core protein 2A / Picornavirus core protein 2A / Picornavirus coat protein VP4 / Picornavirus coat protein (VP4) / Picornavirales 3C/3C-like protease domain ...Poliovirus 3A protein-like / Poliovirus 3A protein like / Picornavirus 2B protein / Poliovirus core protein 3a, soluble domain / Picornavirus 2B protein / Peptidase C3, picornavirus core protein 2A / Picornavirus core protein 2A / Picornavirus coat protein VP4 / Picornavirus coat protein (VP4) / Picornavirales 3C/3C-like protease domain / Picornavirales 3C/3C-like protease domain profile. / Peptidase C3A/C3B, picornaviral / 3C cysteine protease (picornain 3C) / Picornavirus capsid / picornavirus capsid protein / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Picornavirus/Calicivirus coat protein / Viral coat protein subunit / Trypsin-like serine proteases / Thrombin, subunit H / RNA-directed RNA polymerase, C-terminal domain / Viral RNA-dependent RNA polymerase / Reverse transcriptase/Diguanylate cyclase domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Beta Barrel / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Human rhinovirus 2 (ライノウイルス) |
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手法 | X線回折 / 解像度: 1.85 Å |
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データ登録者 | Matthews, D. / Ferre, R.A. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 1999 タイトル: Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. 著者: Matthews, D.A. / Dragovich, P.S. / Webber, S.E. / Fuhrman, S.A. / Patick, A.K. / Zalman, L.S. / Hendrickson, T.F. / Love, R.A. / Prins, T.J. / Marakovits, J.T. / Zhou, R. / Tikhe, J. / Ford, ...著者: Matthews, D.A. / Dragovich, P.S. / Webber, S.E. / Fuhrman, S.A. / Patick, A.K. / Zalman, L.S. / Hendrickson, T.F. / Love, R.A. / Prins, T.J. / Marakovits, J.T. / Zhou, R. / Tikhe, J. / Ford, C.E. / Meador, J.W. / Ferre, R.A. / Brown, E.L. / Binford, S.L. / Brothers, M.A. / DeLisle, D.M. / Worland, S.T. |
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履歴 | 登録 | 1999年8月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 1999年9月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2018年1月31日 | Group: Advisory / Experimental preparation カテゴリ: exptl_crystal_grow / pdbx_unobs_or_zero_occ_atoms Item: _exptl_crystal_grow.temp |
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