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Yorodumi- PDB-1cfa: SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1cfa | ||||||
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Title | SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES | ||||||
Components |
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Keywords | Immune system/INHIBITOR / COMPLEMENT FACTOR / COMPLEMENT ALTERNATE PATHWAY / GLYCOPROTEIN / AGGREGATION INHIBITOR / GP ANTAGONIST / COMPLEMENT FACTOR-PEPTIDE complex / Immune system-INHIBITOR complex | ||||||
Function / homology | Function and homology information Terminal pathway of complement / membrane attack complex / Activation of C3 and C5 / negative regulation of macrophage chemotaxis / complement activation, alternative pathway / chemokine activity / endopeptidase inhibitor activity / positive regulation of vascular endothelial growth factor production / complement activation, classical pathway / positive regulation of chemokine production ...Terminal pathway of complement / membrane attack complex / Activation of C3 and C5 / negative regulation of macrophage chemotaxis / complement activation, alternative pathway / chemokine activity / endopeptidase inhibitor activity / positive regulation of vascular endothelial growth factor production / complement activation, classical pathway / positive regulation of chemokine production / Peptide ligand-binding receptors / Regulation of Complement cascade / chemotaxis / G alpha (i) signalling events / killing of cells of another organism / cell surface receptor signaling pathway / inflammatory response / G protein-coupled receptor signaling pathway / signaling receptor binding / extracellular space / extracellular exosome / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Zhang, X. / Boyar, W. / Galakatos, N. / Gonnella, N.C. | ||||||
Citation | Journal: Protein Sci. / Year: 1997 Title: Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding. Authors: Zhang, X. / Boyar, W. / Galakatos, N. / Gonnella, N.C. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1cfa.cif.gz | 455.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1cfa.ent.gz | 391.3 KB | Display | PDB format |
PDBx/mmJSON format | 1cfa.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/cf/1cfa ftp://data.pdbj.org/pub/pdb/validation_reports/cf/1cfa | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 7950.314 Da / Num. of mol.: 1 / Fragment: RESIDUES 1 - 71 / Mutation: Q71C Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Plasmid: PB-6 / Production host: Escherichia coli (E. coli) / References: UniProt: P01031 |
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#2: Protein/peptide | Mass: 448.561 Da / Num. of mol.: 1 / Fragment: RESIDUES 72 - 75 Source method: isolated from a genetically manipulated source |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Sample conditions | pH: 5.2 / Temperature: 303 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformers submitted total number: 20 |