Entry Database : PDB / ID : 1b4f Structure visualization Downloads & linksTitle OLIGOMERIC STRUCTURE OF THE HUMAN EPHB2 RECEPTOR SAM DOMAIN ComponentsEPHB2 Details Keywords SIGNAL TRANSDUCTION / SAM DOMAIN / EPH RECEPTOR / OLIGOMERFunction / homology Function and homology informationFunction Domain/homology Component
regulation of T-helper 17 type immune response / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / negative regulation of NMDA glutamate receptor activity / hindbrain tangential cell migration / L1CAM interactions / vesicle-mediated intercellular transport / positive regulation of NMDA glutamate receptor activity / regulation of body fluid levels / urogenital system development / postsynaptic membrane assembly ... regulation of T-helper 17 type immune response / trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission / negative regulation of NMDA glutamate receptor activity / hindbrain tangential cell migration / L1CAM interactions / vesicle-mediated intercellular transport / positive regulation of NMDA glutamate receptor activity / regulation of body fluid levels / urogenital system development / postsynaptic membrane assembly / optic nerve morphogenesis / tight junction assembly / neuron projection retraction / axon guidance receptor activity / central nervous system projection neuron axonogenesis / transmembrane-ephrin receptor activity / negative regulation of axonogenesis / positive regulation of long-term neuronal synaptic plasticity / dendritic spine development / corpus callosum development / positive regulation of synaptic plasticity / camera-type eye morphogenesis / positive regulation of dendritic spine morphogenesis / regulation of filopodium assembly / regulation of behavioral fear response / regulation of autophagosome assembly / commissural neuron axon guidance / positive regulation of protein localization to cell surface / negative regulation of cell adhesion / dendritic spine morphogenesis / negative regulation of Ras protein signal transduction / axonal fasciculation / positive regulation of synapse assembly / regulation of receptor signaling pathway via JAK-STAT / EPH-Ephrin signaling / Ephrin signaling / positive regulation of immunoglobulin production / inner ear morphogenesis / retinal ganglion cell axon guidance / B cell activation / roof of mouth development / regulation of blood coagulation / regulation of neuronal synaptic plasticity / EPH-ephrin mediated repulsion of cells / negative regulation of cytokine production involved in inflammatory response / ephrin receptor signaling pathway / positive regulation of B cell proliferation / EPHB-mediated forward signaling / phosphorylation / positive regulation of protein localization to plasma membrane / hippocampal mossy fiber to CA3 synapse / negative regulation of protein phosphorylation / learning / positive regulation of long-term synaptic potentiation / axon guidance / receptor protein-tyrosine kinase / negative regulation of protein kinase activity / peptidyl-tyrosine phosphorylation / negative regulation of ERK1 and ERK2 cascade / cellular response to amyloid-beta / positive regulation of tumor necrosis factor production / nervous system development / presynaptic membrane / amyloid-beta binding / protein tyrosine kinase activity / cellular response to lipopolysaccharide / postsynaptic membrane / angiogenesis / postsynapse / learning or memory / dendritic spine / positive regulation of cell migration / axon / signaling receptor binding / neuronal cell body / glutamatergic synapse / dendrite / positive regulation of gene expression / protein-containing complex binding / cell surface / extracellular region / nucleoplasm / ATP binding / identical protein binding / plasma membrane / cytosol Similarity search - Function Ephrin type-B receptor 2, ligand binding domain / Transcription Factor, Ets-1 / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain ... Ephrin type-B receptor 2, ligand binding domain / Transcription Factor, Ets-1 / Tyrosine-protein kinase ephrin type A/B receptor-like / Tyrosine-protein kinase ephrin type A/B receptor-like / : / Ephrin receptor type-A /type-B / Ephrin receptor ligand binding domain / Tyrosine-protein kinase, receptor class V, conserved site / Ephrin receptor, transmembrane domain / Ephrin receptor ligand binding domain / Ephrin type-A receptor 2 transmembrane domain / Receptor tyrosine kinase class V signature 1. / Receptor tyrosine kinase class V signature 2. / Eph receptor ligand-binding domain profile. / Ephrin receptor ligand binding domain / Putative ephrin-receptor like / SAM domain (Sterile alpha motif) / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Growth factor receptor cysteine-rich domain superfamily / Sterile alpha motif/pointed domain superfamily / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Galactose-binding-like domain superfamily / Fibronectin type III / Fibronectin type III superfamily / DNA polymerase; domain 1 / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MAD / Resolution : 1.95 Å DetailsAuthors Thanos, C.D. / Goodwill, K.E. / Bowie, J.U. CitationJournal : Science / Year : 1999Title : Oligomeric structure of the human EphB2 receptor SAM domain.Authors : Thanos, C.D. / Goodwill, K.E. / Bowie, J.U. History Deposition Dec 20, 1998 Processing site : BNLRevision 1.0 Feb 16, 1999 Provider : repository / Type : Initial releaseRevision 1.1 Mar 24, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Dec 11, 2019 Group : Advisory / Database references / Derived calculationsCategory : pdbx_distant_solvent_atoms / pdbx_struct_assembly ... pdbx_distant_solvent_atoms / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_oper_list / struct_ref_seq_dif Item : _struct_ref_seq_dif.detailsRevision 1.4 Feb 7, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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