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- PDB-1anp: SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SE... -

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Entry
Database: PDB / ID: 1anp
TitleSOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR
ComponentsATRIAL NATRIURETIC PEPTIDE
KeywordsHYPOTENSIVE HORMONE
Function / homology
Function and homology information


negative regulation of collecting lymphatic vessel constriction / : / : / neuropeptide receptor binding / : / mast cell granule / response to 3-methylcholanthrene / receptor guanylyl cyclase signaling pathway / positive regulation of potassium ion export across plasma membrane / cell growth involved in cardiac muscle cell development ...negative regulation of collecting lymphatic vessel constriction / : / : / neuropeptide receptor binding / : / mast cell granule / response to 3-methylcholanthrene / receptor guanylyl cyclase signaling pathway / positive regulation of potassium ion export across plasma membrane / cell growth involved in cardiac muscle cell development / synaptic signaling via neuropeptide / cGMP biosynthetic process / negative regulation of JUN kinase activity / regulation of atrial cardiac muscle cell membrane repolarization / Physiological factors / cardiac conduction system development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / sodium ion export across plasma membrane / neuropeptide hormone activity / hormone receptor binding / negative regulation of systemic arterial blood pressure / glycinergic synapse / cardiac muscle hypertrophy in response to stress / aortic valve morphogenesis / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / : / brush border / cellular response to angiotensin / neuropeptide signaling pathway / positive regulation of heart rate / response to muscle stretch / positive regulation of cardiac muscle contraction / cell projection / cellular response to mechanical stimulus / female pregnancy / negative regulation of cell growth / response to insulin / hormone activity / regulation of blood pressure / vasodilation / cellular response to hydrogen peroxide / protein folding / : / perikaryon / response to hypoxia / Amyloid fiber formation / signaling receptor binding / perinuclear region of cytoplasm / protein-containing complex / extracellular space / extracellular region / cytoplasm
Similarity search - Function
Natriuretic peptide, atrial type / : / Natriuretic peptide, conserved site / Atrial natriuretic peptide / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide
Similarity search - Domain/homology
Natriuretic peptides A
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsFairbrother, W.J. / Mcdowell, R.S. / Cunningham, B.C.
Citation
Journal: Biochemistry / Year: 1994
Title: Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor.
Authors: Fairbrother, W.J. / McDowell, R.S. / Cunningham, B.C.
#1: Journal: Embo J. / Year: 1994
Title: Production of an Atrial Natriuretic Peptide Variant that is Specific for Type-A Receptors
Authors: Cunningham, B.C. / Lowe, D.G. / Li, B. / Bennett, B.D. / Wells, J.A.
History
DepositionApr 6, 1994Processing site: BNL
Revision 1.0Apr 7, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Apr 10, 2024Group: Data collection / Database references / Other
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_ref_seq_dif
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_ref_seq_dif.details

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Assembly

Deposited unit
A: ATRIAL NATRIURETIC PEPTIDE


Theoretical massNumber of molelcules
Total (without water)3,0311
Polymers3,0311
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)11 / -
Representative

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Components

#1: Protein/peptide ATRIAL NATRIURETIC PEPTIDE / Coordinate model: Cα atoms only


Mass: 3031.323 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: POTENTIAL / References: UniProt: P01160

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Processing

NMR ensembleConformers submitted total number: 11

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