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- PDB-1ale: CONFORMATION OF TWO PEPTIDES CORRESPONDING TO HUMAN APOLIPOPROTEI... -

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Entry
Database: PDB / ID: 1ale
TitleCONFORMATION OF TWO PEPTIDES CORRESPONDING TO HUMAN APOLIPOPROTEIN C-I RESIDUES 7-24 AND 35-53 IN THE PRESENCE OF SODIUM DODECYLSULFATE BY CD AND NMR SPECTROSCOPY
ComponentsAPOLIPOPROTEIN C-I PRECURSOR
KeywordsAPOLIPOPROTEIN
Function / homology
Function and homology information


negative regulation of phosphatidylcholine catabolic process / negative regulation of cholesterol transport / lipase inhibitor activity / negative regulation of very-low-density lipoprotein particle clearance / phospholipase inhibitor activity / VLDL assembly / plasma lipoprotein particle remodeling / regulation of cholesterol transport / VLDL clearance / negative regulation of lipid metabolic process ...negative regulation of phosphatidylcholine catabolic process / negative regulation of cholesterol transport / lipase inhibitor activity / negative regulation of very-low-density lipoprotein particle clearance / phospholipase inhibitor activity / VLDL assembly / plasma lipoprotein particle remodeling / regulation of cholesterol transport / VLDL clearance / negative regulation of lipid metabolic process / very-low-density lipoprotein particle assembly / negative regulation of triglyceride catabolic process / chylomicron remnant clearance / negative regulation of receptor-mediated endocytosis / phosphatidylcholine-sterol O-acyltransferase activator activity / negative regulation of fatty acid biosynthetic process / very-low-density lipoprotein particle clearance / lipoprotein metabolic process / phospholipid efflux / chylomicron / high-density lipoprotein particle remodeling / phosphatidylcholine binding / high-density lipoprotein particle / very-low-density lipoprotein particle / cholesterol efflux / triglyceride homeostasis / triglyceride metabolic process / negative regulation of lipid catabolic process / cholesterol metabolic process / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / fatty acid binding / lipid metabolic process / endoplasmic reticulum / extracellular region
Similarity search - Function
Apolipoprotein C-I / Apolipoprotein C-I domain superfamily / Apolipoprotein C-I (ApoC-1)
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsRozek, A. / Buchko, G.W. / Cushley, R.J.
CitationJournal: Biochemistry / Year: 1995
Title: Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy.
Authors: Rozek, A. / Buchko, G.W. / Cushley, R.J.
History
DepositionFeb 20, 1995Processing site: BNL
Revision 1.0Apr 20, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
Revision 1.4May 22, 2024Group: Data collection / Category: chem_comp_atom / chem_comp_bond

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Structure viewerMolecule:
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Assembly

Deposited unit
A: APOLIPOPROTEIN C-I PRECURSOR


Theoretical massNumber of molelcules
Total (without water)2,0811
Polymers2,0811
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)5 / -
Representative

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Components

#1: Protein/peptide APOLIPOPROTEIN C-I PRECURSOR


Mass: 2081.327 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P02654

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR ensembleConformers submitted total number: 5

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