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- EMDB-67114: Cryo-EM structure of human SLC26A11 -

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Basic information

Entry
Database: EMDB / ID: EMD-67114
TitleCryo-EM structure of human SLC26A11
Map data
Sample
  • Complex: SLC26A11 dimer
    • Protein or peptide: Sodium-independent sulfate anion transporter
  • Ligand: CHLORIDE ION
  • Ligand: water
Keywordstransporter / MEMBRANE PROTEIN
Function / homology
Function and homology information


Transport and metabolism of PAPS / oxalate transport / Inorganic anion exchange by SLC26 transporters / sulfate transmembrane transporter activity / secondary active sulfate transmembrane transporter activity / sulfate transmembrane transport / monoatomic anion transmembrane transporter activity / chloride:bicarbonate antiporter activity / chloride channel activity / chloride transmembrane transport ...Transport and metabolism of PAPS / oxalate transport / Inorganic anion exchange by SLC26 transporters / sulfate transmembrane transporter activity / secondary active sulfate transmembrane transporter activity / sulfate transmembrane transport / monoatomic anion transmembrane transporter activity / chloride:bicarbonate antiporter activity / chloride channel activity / chloride transmembrane transport / transmembrane transport / basolateral plasma membrane / apical plasma membrane / lysosomal membrane / Golgi apparatus / endoplasmic reticulum / extracellular exosome / membrane / plasma membrane
Similarity search - Function
Sulphate anion transporter, conserved site / SLC26A transporters signature. / SLC26A/SulP transporter / SLC26A/SulP transporter domain / Sulfate permease family / STAS domain / STAS domain profile. / STAS domain / STAS domain superfamily
Similarity search - Domain/homology
Sodium-independent sulfate anion transporter
Similarity search - Component
Biological speciesHomo sapiens (human)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.82 Å
AuthorsWang Y / Wu S / Wang A / Yan R / Chi X
Funding support China, 1 items
OrganizationGrant numberCountry
National Science Foundation (NSF, China)32471304 China
CitationJournal: Biomolecules / Year: 2026
Title: Structure Basis for Chloride Recognition and Transport by Human Kidney Brain Anion Transporter (KBAT)
Authors: Wang Y / Xie T / Wu S / Wang A / Cheng W / Huang J / Yan R / Chi X
History
DepositionNov 18, 2025-
Header (metadata) releaseSep 30, 2026-
Map releaseSep 30, 2026-
UpdateSep 30, 2026-
Current statusSep 30, 2026Processing site: PDBc / Status: Released

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Structure visualization

Supplemental images

emd_67114.png

Downloads & links

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Map

FileDownload / File: emd_67114.map.gz / Format: CCP4 / Size: 178 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Projections & slices

Image control

Size
Brightness
Contrast
Others
AxesZ (Sec.)Y (Row.)X (Col.)
0.83 Å/pix.
x 360 pix.
= 297.72 Å		0.83 Å/pix.
x 360 pix.
= 297.72 Å		0.83 Å/pix.
x 360 pix.
= 297.72 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 0.827 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy EMDB: 0.18
Minimum - Maximum-0.2745985 - 0.6316469
Average (Standard dev.)-0.00041220238 (±0.027607339)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions360360360
Spacing360360360
CellA=B=C: 297.72 Å
α=β=γ: 90.0 °

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Supplemental data

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Half map: #1

Fileemd_67114_half_map_1.map
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Half map: #2

Fileemd_67114_half_map_2.map
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Sample components

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Entire : SLC26A11 dimer

EntireName: SLC26A11 dimer
Components
  • Complex: SLC26A11 dimer
    • Protein or peptide: Sodium-independent sulfate anion transporter
  • Ligand: CHLORIDE ION
  • Ligand: water

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Supramolecule #1: SLC26A11 dimer

SupramoleculeName: SLC26A11 dimer / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1
Source (natural)Organism: Homo sapiens (human)

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Macromolecule #1: Sodium-independent sulfate anion transporter

MacromoleculeName: Sodium-independent sulfate anion transporter / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 65.344586 KDa
Recombinant expressionOrganism: Homo sapiens (human)
SequenceString: MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM DFVAGLSVGL TAIPQALAYA EVAGLPPQYG LYSAFMGCF VYFFLGTSRD VTLGPTAIMS LLVSFYTFHE PAYAVLLAFL SGCIQLAMGV LRLGFLLDFI SYPVIKGFTS A AAVTIGFG ...String:
MPSSVTALGQ ARSSGPGMAP SACCCSPAAL QRRLPILAWL PSYSLQWLKM DFVAGLSVGL TAIPQALAYA EVAGLPPQYG LYSAFMGCF VYFFLGTSRD VTLGPTAIMS LLVSFYTFHE PAYAVLLAFL SGCIQLAMGV LRLGFLLDFI SYPVIKGFTS A AAVTIGFG QIKNLLGLQN IPRPFFLQVY HTFLRIAETR VGDAVLGLVC MLLLLVLKLM RDHVPPVHPE MPPGVRLSRG LV WAATTAR NALVVSFAAL VAYSFEVTGY QPFILTGETA EGLPPVRIPP FSVTTANGTI SFTEMVQDMG AGLAVVPLMG LLE SIAVAK AFASQNNYRI DANQELLAIG LTNMLGSLVS SYPVTGSFGR TAVNAQSGVC TPAGGLVTGV LVLLSLDYLT SLFY YIPKS ALAAVIIMAV APLFDTKIFR TLWRVKRLDL LPLCVTFLLC FWEVQYGILA GALVSLLMLL HSAARPETKV SEGPV LVLQ PASGLSFPAM EALREEILSR ALEVSPPRCL VLECTHVCSI DYTVVLGLGE LLQDFQKQGV ALAFVGLQVP VLRVLL SAD LKGFQYFSTL EEAEKHLRQE PGTQPYNIRE DSILDQKVAL LKA

UniProtKB: Sodium-independent sulfate anion transporter

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Macromolecule #2: CHLORIDE ION

MacromoleculeName: CHLORIDE ION / type: ligand / ID: 2 / Number of copies: 2 / Formula: CL
Molecular weightTheoretical: 35.453 Da

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Macromolecule #3: water

MacromoleculeName: water / type: ligand / ID: 3 / Number of copies: 4 / Formula: HOH
Molecular weightTheoretical: 18.015 Da
Chemical component information

ChemComp-HOH:
WATER

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 8
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeTFS KRIOS
Image recordingFilm or detector model: FEI FALCON III (4k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: SPOT SCAN / Imaging mode: BRIGHT FIELD / Nominal defocus max: 1.5 µm / Nominal defocus min: 0.8 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
Startup modelType of model: NONE
Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.82 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: cryoSPARC / Number images used: 110238
Initial angle assignmentType: ANGULAR RECONSTITUTION
Final angle assignmentType: MAXIMUM LIKELIHOOD

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