- EMDB-63322: Local reconstruction of bovine adenovirus type 3 capsid -
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データを開く
IDまたはキーワード:
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基本情報
登録情報
データベース: EMDB / ID: EMD-63322
タイトル
Local reconstruction of bovine adenovirus type 3 capsid
マップデータ
試料
複合体: Bovine adenovirus 3
タンパク質・ペプチド: Hexon protein
タンパク質・ペプチド: PVI
タンパク質・ペプチド: Pre-histone-like nucleoprotein
タンパク質・ペプチド: PX
タンパク質・ペプチド: Pre-hexon-linking protein IIIa
タンパク質・ペプチド: PV
タンパク質・ペプチド: Pre-hexon-linking protein VIII
タンパク質・ペプチド: PIX
タンパク質・ペプチド: Penton protein
キーワード
Complex / VIRAL PROTEIN
機能・相同性
機能・相同性情報
hexon binding / viral capsid, decoration / T=25 icosahedral viral capsid / lysis of host organelle involved in viral entry into host cell / host cell nucleolus / microtubule-dependent intracellular transport of viral material towards nucleus / virion component / viral penetration into host nucleus / viral capsid / host cell ...hexon binding / viral capsid, decoration / T=25 icosahedral viral capsid / lysis of host organelle involved in viral entry into host cell / host cell nucleolus / microtubule-dependent intracellular transport of viral material towards nucleus / virion component / viral penetration into host nucleus / viral capsid / host cell / viral nucleocapsid / host cell cytoplasm / endocytosis involved in viral entry into host cell / symbiont entry into host cell / virion attachment to host cell / host cell nucleus / structural molecule activity / DNA binding / membrane 類似検索 - 分子機能
Adenovirus late L2 mu core / Adenovirus late L2 mu core protein (Protein X) / Adenovirus core-capsid bridging protein V / Adenovirus minor core protein PV / Adenoviral core protein VII / Adenoviral core protein VII / Hexon-associated protein IX / Adenovirus hexon-associated protein (IX) / Pre-hexon-linking protein IIIa / Pre-hexon-linking protein IIIa, N-terminal ...Adenovirus late L2 mu core / Adenovirus late L2 mu core protein (Protein X) / Adenovirus core-capsid bridging protein V / Adenovirus minor core protein PV / Adenoviral core protein VII / Adenoviral core protein VII / Hexon-associated protein IX / Adenovirus hexon-associated protein (IX) / Pre-hexon-linking protein IIIa / Pre-hexon-linking protein IIIa, N-terminal / Hexon-associated protein (IIIa) / Pre-hexon-linking protein VIII / Adenovirus Pll, hexon, subdomain 3 / Adenovirus hexon associated protein, protein VIII / Minor capsid protein VI / Minor capsid protein VI / Adenovirus hexon protein / Adenovirus Pll, hexon, N-terminal / Adenovirus Pll, hexon, C-terminal / Adenovirus Pll, hexon, subdomain 2 / Hexon, adenovirus major coat protein, N-terminal domain / Hexon, adenovirus major coat protein, C-terminal domain / Adenovirus penton base protein / Adenovirus penton base protein / Group II dsDNA virus coat/capsid protein 類似検索 - ドメイン・相同性
Pre-histone-like nucleoprotein / Pre-hexon-linking protein VIII / Penton protein / Pre-hexon-linking protein IIIa / PVI / PV / PX / Hexon protein / PIX 類似検索 - 構成要素
National Natural Science Foundation of China (NSFC)
12034006
中国
National Natural Science Foundation of China (NSFC)
32430020
中国
National Natural Science Foundation of China (NSFC)
32371263
中国
National Natural Science Foundation of China (NSFC)
32401014
中国
引用
ジャーナル: J Mol Biol / 年: 2025 タイトル: Structural Insights into Minor and Core Proteins of Bovine Adenovirus 3: Bridging Capsid and Genomic Core. 著者: Hao Xiao / Hao Pang / Junquan Zhou / Hao Feng / Jingdong Song / Lingpeng Cheng / Li Wang / Hongrong Liu / 要旨: Adenoviruses are double-stranded DNA viruses with broad relevance to human and animal health and considerable potential as therapeutic vectors. Despite extensive studies, the structural details of ...Adenoviruses are double-stranded DNA viruses with broad relevance to human and animal health and considerable potential as therapeutic vectors. Despite extensive studies, the structural details of core and minor capsid proteins in adenoviruses remain poorly understood. In this study, the architecture of bovine adenovirus type 3 (BAdV-3), a member of the Mastadenovirus genus, was solved by cryo-electron microscopy. Our structure shows that BAdV-3 shares significant structural conservation with human adenoviruses. Atomic models were constructed for a previously uncharacterized region of the minor protein VI and for the core proteins V and Mu. The study revealed how core proteins bridge the genome and capsid, underscore the multifaceted roles of protein V in strengthening capsid stability and facilitating genome release.