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- EMDB-62842: Cryo-EM structure of the thermophile spliceosome (state B*Q1) -

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基本情報

登録情報
データベース: EMDB / ID: EMD-62842
タイトルCryo-EM structure of the thermophile spliceosome (state B*Q1)
マップデータ
試料
  • 複合体: Spliceosome in state B*Q1
    • RNA: x 4種
    • タンパク質・ペプチド: x 34種
  • リガンド: x 4種
キーワードSpilceosome / DHX15 / DHX35 / GPATCH1 / SPLICING/RNA / SPLICING-RNA complex
機能・相同性
機能・相同性情報


Delta14-sterol reductase activity / spliceosomal complex disassembly / U2-type post-mRNA release spliceosomal complex / ergosterol biosynthetic process / spliceosomal snRNP complex / post-mRNA release spliceosomal complex / generation of catalytic spliceosome for first transesterification step / pICln-Sm protein complex / U2-type catalytic step 1 spliceosome / pre-mRNA binding ...Delta14-sterol reductase activity / spliceosomal complex disassembly / U2-type post-mRNA release spliceosomal complex / ergosterol biosynthetic process / spliceosomal snRNP complex / post-mRNA release spliceosomal complex / generation of catalytic spliceosome for first transesterification step / pICln-Sm protein complex / U2-type catalytic step 1 spliceosome / pre-mRNA binding / snRNP binding / small nuclear ribonucleoprotein complex / SMN-Sm protein complex / spliceosomal tri-snRNP complex / U2-type spliceosomal complex / mRNA cis splicing, via spliceosome / U2-type catalytic step 2 spliceosome / U4 snRNP / U2 snRNP / U1 snRNP / U2-type prespliceosome / precatalytic spliceosome / generation of catalytic spliceosome for second transesterification step / spliceosomal complex assembly / Prp19 complex / protein K63-linked ubiquitination / U5 snRNP / U6 snRNA binding / spliceosomal snRNP assembly / U4/U6 x U5 tri-snRNP complex / catalytic step 2 spliceosome / RNA splicing / peptidyl-prolyl cis-trans isomerase activity / RNA polymerase II CTD heptapeptide repeat P3 isomerase activity / RNA polymerase II CTD heptapeptide repeat P6 isomerase activity / peptidylprolyl isomerase / helicase activity / spliceosomal complex / RING-type E3 ubiquitin transferase / mRNA splicing, via spliceosome / mRNA processing / ubiquitin protein ligase activity / protein folding / hydrolase activity / RNA helicase / DNA repair / mRNA binding / endoplasmic reticulum membrane / RNA binding / zinc ion binding / ATP binding / cytosol / cytoplasm
類似検索 - 分子機能
Sterol biosynthesis ERG24/DHCR-like / Sterol reductase, conserved site / Ergosterol biosynthesis ERG4/ERG24 family / Sterol reductase family signature 1. / Sterol reductase family signature 2. / mRNA splicing factor Cwf18-like / : / cwf18 pre-mRNA splicing factor / Nineteen complex-related protein 2 / PRP39 C-terminal HAT repeat ...Sterol biosynthesis ERG24/DHCR-like / Sterol reductase, conserved site / Ergosterol biosynthesis ERG4/ERG24 family / Sterol reductase family signature 1. / Sterol reductase family signature 2. / mRNA splicing factor Cwf18-like / : / cwf18 pre-mRNA splicing factor / Nineteen complex-related protein 2 / PRP39 C-terminal HAT repeat / Pre-mRNA-splicing factor Isy1 / Pre-mRNA-splicing factor Isy1 superfamily / Isy1-like splicing family / cwf21 / Slt11, RNA recognition motif / Pre-mRNA-splicing factor Cwc2, RNA recognition motif / : / : / Intron-binding protein aquarius, beta-barrel / Intron-binding protein aquarius insert domain / Pre-mRNA-splicing factor SPF27 / Torus domain / Breast carcinoma amplified sequence 2 (BCAS2) / Torus domain / CWF11 family / Intron-binding protein aquarius, N-terminal / Intron-binding protein aquarius N-terminal / mRNA splicing factor SYF2 / SYF2 splicing factor / Helix hairpin bin domain superfamily / : / : / PRP39 N-terminal HAT repeat / mRNA splicing factor Cwf21 domain / cwf21 domain / Pre-mRNA-processing factor 17 / Pre-mRNA-splicing factor 19 / Pre-mRNA-processing factor 19 / : / Prp19/Pso4-like / : / Pre-mRNA-splicing factor SYF1 middle HAT repeat / Myb-like domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / BUD31/G10-related, conserved site / G10 protein signature 1. / : / DNA2/NAM7 helicase, helicase domain / : / AAA domain / STL11, N-terminal / : / Pre-mRNA-splicing factor Syf1/CRNKL1 C-terminal HAT repeat / SKI-interacting protein SKIP, SNW domain / SKI-interacting protein, SKIP / SKIP/SNW domain / : / Pre-mRNA-splicing factor Syf1/CNRKL1 N-terminal HAT repeat / Pre-mRNA-splicing factor Cwf15/Cwc15 / Cwf15/Cwc15 cell cycle control protein / WD repeat Prp46/PLRG1-like / Pre-mRNA-splicing factor Cwc2/Slt11 / : / G10 protein / Pre-mRNA-splicing factor BUD31 / Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal / : / : / pre-mRNA splicing factor component / DNA2/NAM7-like helicase / : / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Anaphase-promoting complex subunit 4, WD40 domain / Myb-like DNA-binding domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / Small nuclear ribonucleoprotein D1 / U-box domain profile. / Anaphase-promoting complex subunit 4 WD40 domain / Modified RING finger domain / U-box domain / Zinc finger, CCCH-type superfamily / Pre-mRNA-splicing factor Syf1-like / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase associated domain (HA2), winged-helix / Helicase-associated domain / Helicase associated domain (HA2) Add an annotation / Small nuclear ribonucleoprotein Sm D3 / Small nuclear ribonucleoprotein Sm D2 / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein G / Small nuclear ribonucleoprotein F / Sm-like protein Lsm7/SmG
類似検索 - ドメイン・相同性
Sm protein F / Putative pre-mRNA splicing protein / RNA helicase / Small nuclear ribonucleoprotein Sm D1 / Putative pre-mRNA splicing protein / Pre-mRNA-splicing factor PRP46 / Pre-mRNA splicing protein / Peptidyl-prolyl cis-trans isomerase / Uncharacterized protein / Delta(14)-sterol reductase ...Sm protein F / Putative pre-mRNA splicing protein / RNA helicase / Small nuclear ribonucleoprotein Sm D1 / Putative pre-mRNA splicing protein / Pre-mRNA-splicing factor PRP46 / Pre-mRNA splicing protein / Peptidyl-prolyl cis-trans isomerase / Uncharacterized protein / Delta(14)-sterol reductase / Putative pre-mRNA splicing protein / Putative bud site selection protein / Pre-mRNA-splicing factor SYF2 / Putative pre-mRNA splicing protein / Putative pre-mRNA splicing protein / Putative pre-mRNA splicing protein / Putative pre-mRNA splicing protein / Putative pre-mRNA splicing protein / Small nuclear ribonucleoprotein E / Anaphase-promoting complex subunit 4-like WD40 domain-containing protein / Uncharacterized protein / Pre-mRNA-splicing factor SPF27 / Pre-mRNA-processing protein 45 / Pre-mRNA-splicing factor / Pre-mRNA-processing factor 19 / Small nuclear ribonucleoprotein Sm D3 / Sm protein B / Small nuclear ribonucleoprotein G / Nineteen complex-related protein 2-domain-containing protein
類似検索 - 構成要素
生物種Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.9 Å
データ登録者Li Y / Fischer P / Wang M / Yuan R / Meng W / Luehrmann R / Lau B / Hurt E / Cheng J
資金援助1件
OrganizationGrant number国
Not funded
引用ジャーナル: Cell Res / 年: 2025
タイトル: Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
著者: Yi Li / Paulina Fischer / Mengjiao Wang / Qianxing Zhou / Aixia Song / Rui Yuan / Wanyu Meng / Fei Xavier Chen / Reinhard Lührmann / Benjamin Lau / Ed Hurt / Jingdong Cheng /
要旨: The spliceosome, a highly dynamic macromolecular assembly, catalyzes the precise removal of introns from pre-mRNAs. Recent studies have provided comprehensive structural insights into the step-wise ...The spliceosome, a highly dynamic macromolecular assembly, catalyzes the precise removal of introns from pre-mRNAs. Recent studies have provided comprehensive structural insights into the step-wise assembly, catalytic splicing and final disassembly of the spliceosome. However, the molecular details of how the spliceosome recognizes and rejects suboptimal splicing substrates remained unclear. Here, we show cryo-electron microscopy structures of spliceosomal quality control complexes from a thermophilic eukaryote, Chaetomium thermophilum. The spliceosomes, henceforth termed B*, are stalled at a catalytically activated state but prior to the first splicing reaction due to an aberrant 5' splice site conformation. This state is recognized by G-patch protein GPATCH1, which is docked onto PRP8-EN and -RH domains and has recruited the cognate DHX35 helicase to its U2 snRNA substrate. In B*, DHX35 has dissociated the U2/branch site helix, while the disassembly helicase DHX15 is docked close to its U6 RNA 3'-end substrate. Our work thus provides mechanistic insights into the concerted action of two spliceosomal helicases in maintaining splicing fidelity by priming spliceosomes that are bound to aberrant splice substrates for disassembly.
履歴
登録2024年12月23日-
ヘッダ(付随情報) 公開2025年3月12日-
マップ公開2025年3月12日-
更新2025年4月16日-
現状2025年4月16日処理サイト: PDBc / 状態: 公開

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構造の表示

添付画像

emd_62842.png

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ファイルダウンロード / ファイル: emd_62842.map.gz / 形式: CCP4 / 大きさ: 421.9 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
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画像のコントロール

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軸Z (Sec.)Y (Row.)X (Col.)
0.93 Å/pix.
x 480 pix.
= 447.36 Å		0.93 Å/pix.
x 480 pix.
= 447.36 Å		0.93 Å/pix.
x 480 pix.
= 447.36 Å

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画像は Spider により作成

ボクセルのサイズX=Y=Z: 0.932 Å
密度

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ヒストグラム (対数)
表面レベル登録者による: 0.0035
最小 - 最大-0.016442008 - 0.06250503
平均 (標準偏差)0.00014650554 (±0.0018862549)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ480480480
Spacing480480480
セルA=B=C: 447.36 Å
α=β=γ: 90.0 °

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試料の構成要素

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全体 : Spliceosome in state B*Q1

全体名称: Spliceosome in state B*Q1
要素
  • 複合体: Spliceosome in state B*Q1
    • RNA: U2 snRNA
    • RNA: U5 snRNA
    • RNA: U6 snRNA
    • タンパク質・ペプチド: PRP8
    • タンパク質・ペプチド: Pre-mRNA-splicing factor SYF2
    • タンパク質・ペプチド: SNU114
    • タンパク質・ペプチド: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
    • タンパク質・ペプチド: CCDC12
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Suppressor of forked domain-containing protein
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Pre-mRNA-splicing factor SPF27
    • タンパク質・ペプチド: Pre-mRNA-processing factor 19
    • タンパク質・ペプチド: Putative bud site selection protein
    • タンパク質・ペプチド: Peptidyl-prolyl cis-trans isomerase
    • タンパク質・ペプチド: Pre-mRNA-splicing factor PRP46
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Pre-mRNA-processing protein 45
    • タンパク質・ペプチド: PRP17
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Pre-mRNA-splicing factor
    • タンパク質・ペプチド: GPATCH1
    • タンパク質・ペプチド: RNA helicase
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein E
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein G
    • タンパク質・ペプチド: Sm protein F
    • タンパク質・ペプチド: Delta(14)-sterol reductase
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein Sm D1
    • タンパク質・ペプチド: Sm protein B
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein Sm D3
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
    • タンパク質・ペプチド: Nineteen complex-related protein 2-domain-containing protein
    • タンパク質・ペプチド: GCFC2
    • タンパク質・ペプチド: TFIP11
    • RNA: Unknown mRNA
    • タンパク質・ペプチド: Putative pre-mRNA splicing protein
  • リガンド: N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)
  • リガンド: MAGNESIUM ION
  • リガンド: GUANOSINE-5'-TRIPHOSPHATE
  • リガンド: ZINC ION

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超分子 #1: Spliceosome in state B*Q1

超分子名称: Spliceosome in state B*Q1 / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#38
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)

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分子 #1: U2 snRNA

分子名称: U2 snRNA / タイプ: rna / ID: 1 / コピー数: 1
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 61.39384 KDa
配列文字列: AGCUCUCUUU GCCUUUUGGC UUAGAUCAAG UGUAGUAUCU GUUCUUUUCA GUUUAAUCUC UGAAACUGCU CUACGGAGCA GAAUCGUGA UUAUACUAAU UUUUGGCCUU CGGCGGACUU CCCUCUGGGC UUGCCCAUGG UCGUCUGCCA CAGUGUCCCU G GUAUUACA ...文字列:
AGCUCUCUUU GCCUUUUGGC UUAGAUCAAG UGUAGUAUCU GUUCUUUUCA GUUUAAUCUC UGAAACUGCU CUACGGAGCA GAAUCGUGA UUAUACUAAU UUUUGGCCUU CGGCGGACUU CCCUCUGGGC UUGCCCAUGG UCGUCUGCCA CAGUGUCCCU G GUAUUACA CUGCCUCCAG GUGACGCGAC CUUCC

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分子 #2: U5 snRNA

分子名称: U5 snRNA / タイプ: rna / ID: 2 / コピー数: 1
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 36.997824 KDa
配列文字列:
UUGGAGUAGG CCAGCUCAGA CCGAACUCAU UUCCUGCCUU UUACCGGAUG UGACCGUGAG UUGGCCUGAA AUACUCCCUA ACCCAAUCU UUGGAAACUC UCUGGAUAUC CCAGAUU

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分子 #3: U6 snRNA

分子名称: U6 snRNA / タイプ: rna / ID: 3 / コピー数: 1
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 32.443285 KDa
配列文字列:
GCCCUUCGGG GCAUUUGGUC AAUUUGAAAC GAUACAGAGA AGAUUAGCAU GGCCCCUGCA CUAAGGAUGA CACGCUACUC AAAGAGACG CUACCAAUUU UU

GENBANK: GENBANK: CU633895.1

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分子 #37: Unknown mRNA

分子名称: Unknown mRNA / タイプ: rna / ID: 37 / コピー数: 1
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 7.235635 KDa
配列文字列:
(P5P)(P5P)(P5P)(Y5P)(P5P)(Y5P)(Y5P)(P5P)(P5P)(P5P) (P5P)(P5P)(Y5P)(P5P)(Y5P)(P5P) (Y5P)(P5P)(Y5P) (N)(Y5P)(Y5P)(Y5P)(Y5P)(Y5P)

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分子 #4: PRP8

分子名称: PRP8 / タイプ: protein_or_peptide / ID: 4 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 285.131 KDa
配列文字列: MLRPCALAIW QGFAPLQSRE SSSRFSLFKP RPVPGFHQHT TLKGEVAISN CGEIVAPISF GLWRIFANRS RSNAGNTATC LRFRRLLPD GGPPPPPPPP PPPPGPPSDL PPPPPPSSSS LPPPPAIPAP PPPGYRPPSD PHIAKFAQKK KEWLRMQRNR F GEKRKGGF ...文字列:
MLRPCALAIW QGFAPLQSRE SSSRFSLFKP RPVPGFHQHT TLKGEVAISN CGEIVAPISF GLWRIFANRS RSNAGNTATC LRFRRLLPD GGPPPPPPPP PPPPGPPSDL PPPPPPSSSS LPPPPAIPAP PPPGYRPPSD PHIAKFAQKK KEWLRMQRNR F GEKRKGGF VETQKADMPP EHLRKIVKDI GDVSQKKYTS DKRSYLGALK FMPHAVLKLL ENMPMPWEAA REVKVLYHVN GC LTLVNEI PRVIEPVFFA QWGSMWRTMR KEKSDRRLFK RMRFPPFDDE EPPLSWSENI EDVEPLEPIQ MELDEDEDAA VYE WFYDHQ PLIDTPHVNG PSYKRWNLTL PQMANLYRLS EPLVSDVVDP NYFYLFELKS FLTAKALNVA LPGGPRFEPL YKDI DPNDE DFGEFNAMDR IIFRNPIRTE TRVAYPYLYN SRPRSVHLSW HSYPQIVYTK TEDPELPAFY FDTSINPISS RAVAP KNLT VSHEDELFGK GNIEEPEEEA FVLPAAVEPF FADEELETED TRSAIELWWA PYPFDRRSGR MVRAQDVPLI KHWYLE HCP PKQPVKVRVS YQKLLKTYVL NELHRKRPKS MQKQSLLRTL KQTKFFQQTT IDWVEAGLQV CRQGFNMLNL LIHRKNL TY LHLDYNFNLK PVKTLTTKER KKSRFGNAFH LMREILRLTK LIVDAQVQYR LGNIDAFQLA DGIHYAFNHV GQLTGMYR Y KYKLMHQIRS CKDLKHLIYY RFNTGPVGKG PGCGFWAPSW RVWLFFMRGI IPLLERWLGN LLSRQFEGRH SKGVAKTVT KQRVESHFDL ELRASVMADL MDMMPEGIKQ SKVNTVLQHL SEAWRCWKSN IPWKVPGLPA PIENIILRYV KAKADWWISV AHYNRERIR RGATVDKTVA KKNVGRLTRL WLKAEQERQH NHMKDGPYVS SEEAVAIYTT TVHWLEARKF SPIPFPSVSY K HDTKILIL ALERLREAYS TKGRLNQSQR EELALIEQAY DSPGTTLERI KRFLLTQRAF KEVGIDMNDN YSTINPVYDV EP IEKISDA YLDQYLWYQA DQRHLFPNWV KPSDSEVPPL LVYKWCQGIN NLDKVWDTSN GECNVIIETQ LSKVYEKIEL TLL NSLLRL IMDHNLADYI TAKNNVTLTY KDMSHVNSYG MIRGLQFSAF VFQYYGLILD LLILGPQRAA EIAGPPQSPN DFLQ FQDRD TETRHPIRLY TRYIDKIWVF LRFTAEESRD LIQRFLTEQP DPNFENVIGF KSKKCWPRDS RMRLMRHDVN LGRAV FWDL KNRLPRSVTT IEWDDTFVSV YSKDNPNLLF SMCGFEVRIL PKCRNQNDEF PVKDSVWSLV DNSTKERTAH AFLQVT EED IQKFNNRIRQ ILMSSGSTTF TKIANKWNTA LIALFTYYRE AAVSTVNLLD TIVKCETKIQ TRVKIGLNSK MPSRFPP AV FYTPKELGGL GMLSGSHILI PASDKRWCKQ TDVGITHFRA GMSHDEETLI PNIARYIIPW EAEFIDSQRV WTEYSQKR L EAQQQNRRLT LEDLEDSWDR GLPRINTLFQ KDRSTLSFDK GFRARAEFKI YQLMKSNPFW WTNPRHDGKL WNLNAYRTD VIQALGGVET ILEHTLFKAT GFPSWEGLFW EKSSGFEASM QFKKLTNAQR SGLNQIPNRR FTLWWSPTIN RANVYVGFQV QLDLTGIFL HGKIPTLKIS LIQIFRAHLW QKIHESVVMD LCQVFDQELE ALSIESVQKE TIHPRKSYKM NSSCADIQLF A SHKWNVTR PSLLFDTKDV IEATTTNKFW IDVQLRYGDY DSHDIERYVR AKYLDYTTDS MSLYPSPTGL MIGIDLAYNL YS AYGQYFP GLKTLIQQAM AKIMKANPAL YVLRERIRKG LQLYASESNQ EFLNSQNYSE LFSNQTQLFI DDTNVYRVTI HKT FEGNLT TKPINGAIFI FNPRTGQLFL KIIHTSVWAG QKRLGQLAKW KTAEEVAALI RSLPVEEQPK QLIVTRKGLL DPLE VNLVD FPNISIRASE LQLPFQAAMK VEKLGDMILR ATEPQMVLFN LYDDWLKTIS SYTAFSRLIL ILRALHVNQD KTKLI LRPD KTVITQDHHI WPSLTDEDWI KVEMQLRDLI LNDYGKKNNV NVASLTTSEV RDIILGMEIS APSLQRQQAA EIEKQQ QEQ AQLTAVTTKT QNVHGEEIIV TTTSQFEQQT FASKTEWRTR AIATSNLRTR ANNMYVAPVD NDVDDITYVM PKNILKK FI TIADLRVQVA GFLYGCSPAD NDQVKEIRCI VMVPQIGGNR SVQLPQHLPQ HEMLKGLEPL GLIHTMAGNE LPYMSPAD V TTHAKLVDAH PSWKNQNTLT VTVAFTPGSV SLSAWALTPL GYKWGVENKD PNVDNPQGFT TTMGERRQLL LSDKFKGFF LVPDTGKWNY SFMGSSFSGI EKKPYHVKLD TPLPFYSEQH RPIHFTSFNE LEDIWVDRAD NFA

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分子 #5: Pre-mRNA-splicing factor SYF2

分子名称: Pre-mRNA-splicing factor SYF2 / タイプ: protein_or_peptide / ID: 5 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 36.945891 KDa
配列文字列: MPPAKKRKTE ASQEPRPASE QQEQNGAQEE QPTVQDSTPE VESRSDDKKV SQSPTLATDP SDDTSEQPSE SSTKNAALTA AQERLARFR ALQARAKESS QQNLKEATKE SQRLATDPSQ LTALSRKHAI AAHKLLKAEI EDAGGDFERK RAWDWTVEEA E RWDKRMKK ...文字列:
MPPAKKRKTE ASQEPRPASE QQEQNGAQEE QPTVQDSTPE VESRSDDKKV SQSPTLATDP SDDTSEQPSE SSTKNAALTA AQERLARFR ALQARAKESS QQNLKEATKE SQRLATDPSQ LTALSRKHAI AAHKLLKAEI EDAGGDFERK RAWDWTVEEA E RWDKRMKK KEAHRDDTAF RDYAREAEKT YKRQIRNMGA PDLEKYMREK LSAIEKAAAA GTLDIIETED GEMIAVDKDG TF FSTANAT DFAQHKPDKA AVDRLVADLR KAEEASLKRR REKLAKSGEE HGDVTYINEK NKQFNAKLAR FYNKYTAEIR DSF ERGTMV

UniProtKB: Pre-mRNA-splicing factor SYF2

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分子 #6: SNU114

分子名称: SNU114 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 113.867617 KDa
配列文字列: MWQRATRLRL SESFGPSTTD SNHTFPDLAA TMDDDLYDEF GNFIGEEAES EEESDHGANA GVYAYDEYVD EAPEEPAEEQ MDIDEEPPS NAVILHEDKQ YYPTAAQVFG EGVETLVQEE DAQPLTQPII APVEQKKFSI QEADLPPVYF DRGFMTDLMN F PEQIRNIA ...文字列:
MWQRATRLRL SESFGPSTTD SNHTFPDLAA TMDDDLYDEF GNFIGEEAES EEESDHGANA GVYAYDEYVD EAPEEPAEEQ MDIDEEPPS NAVILHEDKQ YYPTAAQVFG EGVETLVQEE DAQPLTQPII APVEQKKFSI QEADLPPVYF DRGFMTDLMN F PEQIRNIA LAGHLHHGKT AFMDMLVLET HAIQERLDKR TGKKRDEQLR YTDVHVIERD RGLSIKAAPM SLVLSSTKGK SH LFNIIDT PGHVDFVDEV AAAFRLVDGV CLVVDVVEGV QVNTEQIIKH AVLEDIPLTL IINKMDRLIL ELKIPPTDAY FKL KHVIEE VNTVIENTIP GRGESKRLSP EKGNVLFACT SMGWCFTLQS FAKMYSESYG GVNVEEFARR LWGDVYFNPK KRTF TRKPI EEGAKRSFVN FVMEPIYKLY SHTISEGPED LKRTLSKLGI FLKPSQYKAD PKVLMKLVCE QFFGPSTAFV DMVIK HIPS PLEAAEKKLE RYYTGPLDTK IAESMKNCDQ NGPLVVHVTK LFNTIDAKSF YAFGRVMSGI ARPGADVRVL GEGYTL DDE EDMVVSRISD VFIAETRYNI PTDGVPAGNF VLLGGVDNSI VKTATIVDKK FDNGEDAYVF KPLSHFTESV LKVAVEP IN PSELPKMLDG IRKINKSYPL ITTKVEESGE HIILGTGELY MDCVLHDLRK LYADMEVRVS DPVVRFCETV QDMSATKC Y AITPNKKNTI TMAAEPLDDG IAQDIESGAV KIKDPPRKVA KFFEEKYGWD KLAARSIWAF GPDEMGPNIL QDDTLPTEV DKKRLATVKE SIRQGFAWAT REGPLCEEPI RNTKFRLIDV SLFPWWWPNY SDRSTCLLFL FLDGLPRLME PMYSVSMTGP QSSVSMVYN ILSRRRGHVL SDGPIAGTPL YRVNGLIPVI DSFGFETDLR INTPGQAMVS LVFDRWSIVP GDPLDREQVT R PLQMATAQ ATARDFVLKT RRRKGLSEDV TVAKFLEPEF YQSLLESGTL GEP

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分子 #7: Anaphase-promoting complex subunit 4-like WD40 domain-containing ...

分子名称: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 38.229977 KDa
配列文字列: MSEKRPASDD PGEGQLVVKR QNVGSSRALT RTGDSAGALI QTTPRTSNLK APLMELSGHT GEIFTAKFDP TGTLIASGSM DRTIMLWRV YGDCENYGVL NGHKAAILDL QWSRDGDILF SASADMHLAS WDLTTGQRIR RYIGHEEIIN AMDVTQRGEE L LISGSDDG ...文字列:
MSEKRPASDD PGEGQLVVKR QNVGSSRALT RTGDSAGALI QTTPRTSNLK APLMELSGHT GEIFTAKFDP TGTLIASGSM DRTIMLWRV YGDCENYGVL NGHKAAILDL QWSRDGDILF SASADMHLAS WDLTTGQRIR RYIGHEEIIN AMDVTQRGEE L LISGSDDG TIGIWDPRTK NAVDYIETDF PITAVAVSEA GNEIYSGGID NDIKVWDIRK KAVVHTMLGH NDTITTLRVS PD GQQLLSY AMDSTARTWD IRPFAPTDRH IRTFDGAPLG LEKNLIRGSW SKDGKKIAVG AGDGTVVIWG SDTGKLLYKL PGH KGTVNC AEFAPDGAPI ILSASSDRTM LLGELI

UniProtKB: Anaphase-promoting complex subunit 4-like WD40 domain-containing protein

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分子 #8: CCDC12

分子名称: CCDC12 / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 25.360002 KDa
配列文字列: MSSYSSLSAA ADERKARLAK LASLKRKQPE DDHPPSQDQQ PEQSAAESKQ EGDSSQASDP VLQHLSLRNY DPVTRGPKLG FEAPPTENL NTLTLEEKAA ALEAEARRKA QEEQEAAAQA RGLDITTLQP KKPNWDLKRE FKQRMAVLDV RTENAIARMV R ERLAEKKK ...文字列:
MSSYSSLSAA ADERKARLAK LASLKRKQPE DDHPPSQDQQ PEQSAAESKQ EGDSSQASDP VLQHLSLRNY DPVTRGPKLG FEAPPTENL NTLTLEEKAA ALEAEARRKA QEEQEAAAQA RGLDITTLQP KKPNWDLKRE FKQRMAVLDV RTENAIARMV R ERLAEKKK AIVGASAAAS GAADGAASGG GNNGKGEEGV LEGAEILEGM RMREKEEEEE ARREKEAEEA EFGTA

UniProtKB: Uncharacterized protein

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分子 #9: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 97.944164 KDa
配列文字列: MPSTLASDRQ PDVALVCEDD APYEQDILRN PGSIRPWLSY IEYKLQHGTL REQAFVMERA CVQLPRSYKL WKMFRVNHIS KLNPAIFAT EYQKVNALFE RALILLNKMP RIWEMYLKFL MQQPLVTFTR RTFDRALRAL PITQHNRIWA LYRPFANSAE G ITAVKIWR ...文字列:
MPSTLASDRQ PDVALVCEDD APYEQDILRN PGSIRPWLSY IEYKLQHGTL REQAFVMERA CVQLPRSYKL WKMFRVNHIS KLNPAIFAT EYQKVNALFE RALILLNKMP RIWEMYLKFL MQQPLVTFTR RTFDRALRAL PITQHNRIWA LYRPFANSAE G ITAVKIWR RYMQVHPEDA EDFIELLIQC GLYTEAVKKY IEILNNPKFQ SKNAKGHYEL WSEMVDLLVE HAVDIETGHE TG IDVERII RSGIERFSDQ RGKLWSGLAT YWIRRGNFDR ARDVFEEGIT TVMTVRDFTM IFDAYVEFEE SVIGTLMEAA SRR AEKGVV DESADFDLDI RMMRFEHLMD RRPFLLNDVL LRQNPNNVAE WEKRVALWGD NKEEVVKTYT DAIAAINPKK AVGA FHLLW ANYAKFYEKA GDLRTARIIM EKAVKVPFKS VNELADMWIE WAEMELRNKN FDEAVRIMAK ATQAPKRSTV DYFDE SLSP QQRVHKSWKL WSFYVDLVES TSSLEETRKI YERIFELRIA TPQTVVNYAN LLEEHHYYEE SFKIYERGLD LFSYPV AFE LWNLYLTKAV DRKISIERLR DLFEQAITDC PPKFAKVLYL MYGNLEEERG LARHAMRIYE RATRAVADED RADMFNF YI TKSASNFGLA STRPIYERAI ATLPDNEARD MCLKFADMEK RLGEIDRARA IYGHASQFCD PRTNPEFWAK WEQFEVQH G NEDTFKEMLR VKRSVQAKYN TDVNFIASQA LARSQMLKQQ QQQQQQQQQQ QLQQQQQNGS SGAGDPEVAD AMAQLERQA RAPAGFVAAS ENIKGTIAPS TQSVEVSNPD AIDLDDMDE

UniProtKB: Putative pre-mRNA splicing protein

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分子 #10: Suppressor of forked domain-containing protein

分子名称: Suppressor of forked domain-containing protein / タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 82.195375 KDa
配列文字列: MESSRGPPRV KNKAPAPIQI SAEQLLREAV DRQETIIHKP TQRFADLEEL KEYQGRKRRE FEDYIRRNRL RLQNWFQYAQ WELEQKEFA RARSIFERAL DVHPNNTQLW IRYIEAELKN RNINHARNLL DRAVTRLPRV SKLWYKYVYV MEMLGDIPGT R QVFDRWMK ...文字列:
MESSRGPPRV KNKAPAPIQI SAEQLLREAV DRQETIIHKP TQRFADLEEL KEYQGRKRRE FEDYIRRNRL RLQNWFQYAQ WELEQKEFA RARSIFERAL DVHPNNTQLW IRYIEAELKN RNINHARNLL DRAVTRLPRV SKLWYKYVYV MEMLGDIPGT R QVFDRWMK WEPDEDAWNA YIKLEKRYGE YERARQIFAA YTQVHPEPRT WLKWAKFEEE FGTADMVRDV FQSAIQYIAE TL GDDAVDE RLFIAFARFE TRQKEYERAR AIYKFGLDNL PRSRSMQLHA QYTTFEKQFG DKEGVEDVVL TKRRRLYEEQ VKE NPKNYD VWFDFARLEE MGGDPDRVRE VYERAIAQVP PTQEKRHWRR YIFLFLFYAI WEEKDAKNIE RARAIYDTCL NLIP HKKFT FAKVWIAKAH FEIRQGNLTA ARKTLGRAIG MCPKDKLFRE YIAIEQKLYE FDRCRTLYEK HALFNPANCQ TWIRW AELE RGLDDLDRTR AIFEVAISQP VLDMPEVVWK AYIDFEEEEG EYERARALYE RLLQKADHPK VWISYAQFEI NIPDTE TEA QAAEGEEIPV SEAAKARARG VFERALKSMK ERDLKAERVA LLRAWLEFER THGAAEDVER IRRQMPREVK KKRRIDE DT WEEYVDYVFP ADEQQTKNLS NLLAMAKQWK EKTGGGIMGL GAGGS

UniProtKB: Pre-mRNA splicing protein

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分子 #11: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 86.636156 KDa
配列文字列: MPVVKGGVWT NIEDEILKAA VSKYGLNQWA RVSSLLARKT PKQCKARWNE WLDPSIKKIE WSREEDEKLL HLAKLMPTQW RTIAPIVGR TANQCLERYQ KLLDEAEQRE ASELGLTGPD GGETRAPTAE DVRKLRPGEI DPDPETKPAR PDTIDLDEDE K EMLSEARA ...文字列:
MPVVKGGVWT NIEDEILKAA VSKYGLNQWA RVSSLLARKT PKQCKARWNE WLDPSIKKIE WSREEDEKLL HLAKLMPTQW RTIAPIVGR TANQCLERYQ KLLDEAEQRE ASELGLTGPD GGETRAPTAE DVRKLRPGEI DPDPETKPAR PDTIDLDEDE K EMLSEARA RLANTQGKKA KRKARERQQE ESRRLAALQK RRELKTAGIN IKITTRKKGQ MDYNADIPFE KKPAPGFYDT TE EIARNEW QRAHFDPKKQ QVGNKRKSDE EEEAERKKRK NNKDGPSASL QAALKAGQMQ KLREAEQSSK RKPLILPAPQ VSD SELDEI VKMGMIGERA SAMARESEND ATRGLVGNYS TLNTGAPIRT PRAPAQEDHI ANEIRNIKAL TETQSSLLGG ENAP LAEGA GTTGFESVVP KKQVVSTPNP LATPLRQGPN GGATPLRPGQ TPLRTPRDTF SLNATDGVSM EHALRQQLKQ KLAAL PKPK ETEWELELPE EKQEPKTQEE LEEDAADRDR RERELREARE LAERRRRTQV MQRELPRTAV VDIDALLRAA DEIEDP ARA LVAREAALLM AHDAAKYPLP GAPPGVKPVE IPRFSDDELA EARLQILMEM KEKPAPEVVH AIWNRREENL NALRLGL GY YDSDSEDGED DVANIRATLE AALDRLMASA EKGNKLEKKL NLHLGGYKNR AEMLRKKLGE AHAALEKARN ALAGFQVL R ASEEQAIQRR LEALRAEVAF VSTRERKAQE LYRKLRDELE ELRLEQA

UniProtKB: Putative pre-mRNA splicing protein

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分子 #12: Pre-mRNA-splicing factor SPF27

分子名称: Pre-mRNA-splicing factor SPF27 / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 25.550703 KDa
配列文字列: MPAITTVHES LPYIDPEPTP EQRAAAEALI AEERAKVPDD PYHALLPPPL PPLNESRHLT PILQNELARL ASSPDPQAAK MDALDFSRY EAPEMPSIDS SQSLEETASQ LWETLKQAYT AQAYLSARRA HLALLDTHGK NAWLIGNWHL EGEVKAVEKE L AETKREID ...文字列:
MPAITTVHES LPYIDPEPTP EQRAAAEALI AEERAKVPDD PYHALLPPPL PPLNESRHLT PILQNELARL ASSPDPQAAK MDALDFSRY EAPEMPSIDS SQSLEETASQ LWETLKQAYT AQAYLSARRA HLALLDTHGK NAWLIGNWHL EGEVKAVEKE L AETKREID RVSLARQGMQ EAAGAELKSL EETWKAGVGR VLETEAAAEK LRIEVLEERR RLAEAQAALA VGN

UniProtKB: Pre-mRNA-splicing factor SPF27

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分子 #13: Pre-mRNA-processing factor 19

分子名称: Pre-mRNA-processing factor 19 / タイプ: protein_or_peptide / ID: 13 / コピー数: 4 / 光学異性体: LEVO / EC番号: RING-type E3 ubiquitin transferase
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 51.844324 KDa
配列文字列: MLCALSGEIP EEPVVSKKTG VLFEKRLILK YLEEHNNIEP GTTEELDPET DLLPIKTSRV VRPRPPNFTS IPSLLKAFQD EWDALVLET YTTREQLARV REELATALYQ HDAAVRVIAR LTRERDEARE ALARLTVTGA APAAQNGEAM AVDSESLSEG L VEHVNEVQ ...文字列:
MLCALSGEIP EEPVVSKKTG VLFEKRLILK YLEEHNNIEP GTTEELDPET DLLPIKTSRV VRPRPPNFTS IPSLLKAFQD EWDALVLET YTTREQLARV REELATALYQ HDAAVRVIAR LTRERDEARE ALARLTVTGA APAAQNGEAM AVDSESLSEG L VEHVNEVQ QQLMKTRKKR PIPQGWATAD DVAALQQVAY TDLNVTQASS LDLENECAAV GGLDGKLDIY SVVANKVERT LD IGEPVTA TEWTGTKVVI GTAKGWVKVY DAGRESATFQ THAGPVTGLA VHPGGRILAS VGVDKSFVFY DLETGERVAR GYA DAALTT CAFHPDGNLF AAGTQTGHIL VFHTTTLEQA ESFPLGTPIQ ALAFSENGFW FAATGKGTSS VTIFDLRKSG AAAA VKELQ TGEVLSISWD YTGQYLATGG GTGVTVQMYT KATKSWSEPV RLGMPVVGVK WGGEAKRLVV VSREGVVSVL GKKEE

UniProtKB: Pre-mRNA-processing factor 19

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分子 #14: Putative bud site selection protein

分子名称: Putative bud site selection protein / タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 17.176775 KDa
配列文字列:
MPAIRPASKR KPPPDGFSDI EEDLLIFANK MKDAQNTPTD NIPKHQAQWP IFQIAHQRSR YVYELYYQKQ AISKQLYDWL LKNGYADAM LIAKWKKQGY EKLCCLRCIQ TKETNFNSTC ICRVPRAQLK EDQDIQCVNC GCRGCASTD

UniProtKB: Putative bud site selection protein

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分子 #15: Peptidyl-prolyl cis-trans isomerase

分子名称: Peptidyl-prolyl cis-trans isomerase / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO / EC番号: peptidylprolyl isomerase
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 18.361811 KDa
配列文字列:
MATDVALETT MGTIILELYN QHAPRTCENF KTLAARGYYD GTIFHRVIKD FMVQGGDPTG TGRGGRSIYG DTFEDEIHPG LRHTGAGIL SMANAGPNTN GSQFFLTLAP TPWLDGKHTI FGRVKKGIRV LQRMGLVPTD ADDRPKTEIK IIRAYVVGEG E EDDKQLV

UniProtKB: Peptidyl-prolyl cis-trans isomerase

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分子 #16: Pre-mRNA-splicing factor PRP46

分子名称: Pre-mRNA-splicing factor PRP46 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 54.207328 KDa
配列文字列: MATDVAVNGP DVSKLEALLR DNERTTRSLY ASTTPDSGRK RIKLDPGLAS EDPDITKSAL SLRLHAEYGD VQTLPEAIAK KLSAAGPRK KKPKPGVAED EAPSKSEEHT RKLIEGIPQA KPSAGAASSN ALVLAHGKPS AAGAGAARPQ RNEPQQLSLV R RSESLLAQ ...文字列:
MATDVAVNGP DVSKLEALLR DNERTTRSLY ASTTPDSGRK RIKLDPGLAS EDPDITKSAL SLRLHAEYGD VQTLPEAIAK KLSAAGPRK KKPKPGVAED EAPSKSEEHT RKLIEGIPQA KPSAGAASSN ALVLAHGKPS AAGAGAARPQ RNEPQQLSLV R RSESLLAQ PRPDWHPPWK LMRVISGHLG WVRALAVEPN NQWFASGAGD RTIKIWDLAS GQLRLTLTGH ISTVRGLAVS PR HPYMFSC GEDKMVKCWD LETNKVIRHY HGHLSGVYTL KLHPTLDVLV TGGRDGVARV WDMRTRSNVH VLSGHTGTVA DLV CQEADP QVITGSLDST VRMWDLAAGK TMGVLTHHKK GVRALVTHPT EFTFATASTG SIKQWKCPEG AFMQNFEGHN AIIN TLAVN DQNVLFSGGD NGSMSFWDWK SGYRFQSLDT TAQPGSLDAE LGIMSSTFDM SGARLITGEA DKTIKIWKED TTATP ETHP IEWKPSLVRR KY

UniProtKB: Pre-mRNA-splicing factor PRP46

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分子 #17: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 42.241816 KDa
配列文字列: MPPQIKQDLN RAGWESTDFP SVCENCLPEN PYVKMLKEDY GAECKLCTRP FTVFSWAGDG RAHGRKKRTN ICLTCARLKN ACQCCIMDL QFGLPIVIRD KALELIAPGP QSEINREYFA QNNERAIEEG RAGVEEYEKT DEKARELLRR LANSKPYFRK G RELDSEGN ...文字列:
MPPQIKQDLN RAGWESTDFP SVCENCLPEN PYVKMLKEDY GAECKLCTRP FTVFSWAGDG RAHGRKKRTN ICLTCARLKN ACQCCIMDL QFGLPIVIRD KALELIAPGP QSEINREYFA QNNERAIEEG RAGVEEYEKT DEKARELLRR LANSKPYFRK G RELDSEGN PVAGGSGSTV GGNAVVGAGL GGAGPIRTRD TRAAAAAGAR TGGAGSARRG PGAALPPPGP KDWLPPADKS IM SLFITGI EDDLPEWKIR DFFKQYGKIK SLVVSHMTHC AFVNYETREG AEKAATELKG RAVIAGCPLR IRWSIPRPIG TMN KEERAE MLRDGRSAFP EANRKSAQKA IEAAGAQGGA AGGAAGGAAA EAQQDDLADL AIAAPPGAAD VQYASLAGN

UniProtKB: Putative pre-mRNA splicing protein

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分子 #18: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 45.885184 KDa
配列文字列: MAELETNPDV AVAVAEDSNE QKQENQLVAV NNEVAAPIEK KVKKIIRKKR RPARPQIDPA LVKSERPPQT GTVFNIWYNK WSGGDREDK YLSQTHAKGR CNIARDSGYT RADSRPGSYF CLYFARGICP KGQDCDYLHR LPTIHDIFNP NVDCFGRDKF A DYRDDMGG ...文字列:
MAELETNPDV AVAVAEDSNE QKQENQLVAV NNEVAAPIEK KVKKIIRKKR RPARPQIDPA LVKSERPPQT GTVFNIWYNK WSGGDREDK YLSQTHAKGR CNIARDSGYT RADSRPGSYF CLYFARGICP KGQDCDYLHR LPTIHDIFNP NVDCFGRDKF A DYRDDMGG VGSFNRQNRT IYVGRIHVTD DIEEIVARHF AEWGQIERIR VLNNRGVAFI TYTNEANAQF AKEAMAHQSL DH NEILNVR WATADPNPLA QKREQRRIEE QAAEAIRRAL PAEFVAEIEG KDPEARKRRK LESSYGLEGY EAPDAVHFAR GPN AVNPRG REGFELEREQ QLMLEAPPET SQPAQIEAPP QAQEKKLAGG ILSSRTLAAL QGAKVAVATK DSKPEKPSGP LVAY GSDDE EDE

UniProtKB: Putative pre-mRNA splicing protein

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分子 #19: Pre-mRNA-processing protein 45

分子名称: Pre-mRNA-processing protein 45 / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 65.034551 KDa
配列文字列: MASIAAGLAA ALPKPKYSSE HEEPRATQRG PRIVSADQID ETQIVIRRTG PPPYPNRAGW RPRAPEDFGD GGAFPEIPVA QYPWGKNDS SSKSNALVVQ VDSEGKVDYT AIARQGHSSD RIIHASFKDL IPLRQRAEAG QIDLSRPSKE EVEATAERTK N ALAALVSG ...文字列:
MASIAAGLAA ALPKPKYSSE HEEPRATQRG PRIVSADQID ETQIVIRRTG PPPYPNRAGW RPRAPEDFGD GGAFPEIPVA QYPWGKNDS SSKSNALVVQ VDSEGKVDYT AIARQGHSSD RIIHASFKDL IPLRQRAEAG QIDLSRPSKE EVEATAERTK N ALAALVSG ALAAQKPKNV QVNTKREATF VKYTPSAQMG NNTKKQERII KIVERQRDPM EPPKFKHKKI PRGPPSPPPP VM HSPPRKL TAEDQEAWRI PPPVSMWKNP KGFTIPLDKR LAADGRQLQE VQINDKFAQF SEALFMADRH AREEVRQRAM MQQ RLAEKE RQQKEEHLRQ LAQQARAERA AAAASGRRRS TRSRSGSYSG SESGSETDES ERERRRARRE KLKEEERKLR QSRM GAERR AQVLAREMDR DISEKIALGI AKPTMSGESM YDSRLFNQSS GFGATINEDN PYDKPLFAAQ EAISSIYRPR TNAEY EDDE EAGEKEMERI RKGNRFGEAL GRGTFKGTED AQPREGPVQF EKDTETADPF NVDKFLSEVQ KGSNSGGGKR GYGLQD EDS RQAKRSRVDD DENDD

UniProtKB: Pre-mRNA-processing protein 45

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分子 #20: PRP17

分子名称: PRP17 / タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 61.222004 KDa
配列文字列: MPDFGEYPPN LPVRDALILR ESQAQAPTAN HAVVPYTGEN LARPSYGPAN PFRDTSSSSA SASGSLKRKN NVLTGHAEEM YISEATFRA KHRAVEAVGG GVMRSNREMK EVNKRLREMR EDKGSATIAD GEGAYIGPWA RYKRREEYEV VDKKGEEEDG D EYEEVEVT ...文字列:
MPDFGEYPPN LPVRDALILR ESQAQAPTAN HAVVPYTGEN LARPSYGPAN PFRDTSSSSA SASGSLKRKN NVLTGHAEEM YISEATFRA KHRAVEAVGG GVMRSNREMK EVNKRLREMR EDKGSATIAD GEGAYIGPWA RYKRREEYEV VDKKGEEEDG D EYEEVEVT DEEEEVIESG TVLKAPEPAI ARRKEAEEMG EERTEFLGES EYDYLGRTYM HVPQDLDVSL NKEVGSITNY IP KKLIYTW RHHGGKPITA LQLFPRSSHL GLAGSADGVV KIFDVYRGRE LLRSYSGHNK AITDLSFCND GTKFLSGGFD RKI RLWDTE TGQCVNRFNI GKTPHVIKFN PSSENGHEFL AGLSDKRIVQ YDTRAGNDTV QEYDRHLGPI NTIEYIDENR RFMS TSDDR SLKVWEYGIP VEIKTISEPD MFALTKSAQH PNGKYVLYQC SDNSIVAYSC SGDKFRQHRK KAWRGHNTAG SAIGL TCSP DGQFVASGDT SGSVCFWDFK TCKLYSKLTA DSAGGIINCV AWSEQETSKV FTAGAKGEIK LWD

UniProtKB: Uncharacterized protein

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分子 #21: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 28.956562 KDa
配列文字列: MTTAHRPTFD PARGKEALRG PAYHQRLLPA YTTLKFRQPG QGGAADKSTR DLRAELEAAE AAHYAKLKGA PIPGTSSSSE NNTPAIAGS SASSVTGKRP LPSSSNGGGD RPPDDGDEDP EAKRRRILAE TRDIDADDDS SSGSDKDSDS ESGSADSDDS S DDEEAELQ ...文字列:
MTTAHRPTFD PARGKEALRG PAYHQRLLPA YTTLKFRQPG QGGAADKSTR DLRAELEAAE AAHYAKLKGA PIPGTSSSSE NNTPAIAGS SASSVTGKRP LPSSSNGGGD RPPDDGDEDP EAKRRRILAE TRDIDADDDS SSGSDKDSDS ESGSADSDDS S DDEEAELQ RELERVRRER MEKRAREEAE RKAAEEARRE EEIARGNPLL NKPDFTVKRR WDEDVVFKNQ ARGTEDKGKR KE FVNDLLR SDFHKRFMSK YVR

UniProtKB: Putative pre-mRNA splicing protein

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分子 #22: Pre-mRNA-splicing factor

分子名称: Pre-mRNA-splicing factor / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 161.045484 KDa
配列文字列: MPPAKRIKSS ADSRPNAGAS GRPTLEDLEG ENQFTNLARQ HWLNVPQQAA KIKVKTDVLK RELYLWPGYG EDSSNYHVLL IILIVNAKR RERVSTWDIF ADRPADFSDL FRRALSMTLD SSLSWTIRTH VLLFIIHAFQ SLDYAIVRKE CAPLVSISIW H NLSTEEKR ...文字列:
MPPAKRIKSS ADSRPNAGAS GRPTLEDLEG ENQFTNLARQ HWLNVPQQAA KIKVKTDVLK RELYLWPGYG EDSSNYHVLL IILIVNAKR RERVSTWDIF ADRPADFSDL FRRALSMTLD SSLSWTIRTH VLLFIIHAFQ SLDYAIVRKE CAPLVSISIW H NLSTEEKR EALLDSNPHL RKAWRAATKR FESADDATKA RLRFDRAWLY SLVLDFLTLL YSGNAKQEHV LYCERFVEFL TD LQSQLPT RRYVNTLLQD LHVLPALSLS PIYNDEGNGL LRELCNLFTH YTYFAVDDQS GVQLSREQAY DRHCAILAKL QRI AMKHFK EKLTVLALSN YGSIDKRSEL EPLLQALTDD ELVQLSNLMN IRTSYPDAAR IPVDRKFIVE VLLTTFERRK TFQD AAQAL SVLPTEETLF DISLKRTDQY DGSRPLALPK LNLQYLSVGD FLWRSFVLYR CESFYAIRQD LEDALIRLKP EVRRG GVTG FAGFSKMALP ISKPVILDVM PPQVGDDKPS CVKAEVTIDL RRLTPQIRRD WESLRPDDVV FLLAVDASRQ KQSANG GAV LSEAERLGLV HVRAAEIIQV LDDKGKAIRD PQAYFDGHTR SDIRKIQLRL DATSYKADTE ANRNVYEDIN LIVRRSS RE NNFKPVLESI QDLTLSEVPL ASWLHEVFLG YGDPAGATFK QLPNRLKKIN FRDTFLDWQH LVESFPGKII EPSDDVSS S FGPPYVLESV EKQVEEHPSK PSKKRRRDVE PALMSKVETL KVSTYKPPNN GPYPVDAPKL NKIRFTPTQI DAIYSGTQP GLTIIVGPPG TGKTDVAVQI ISNIYHNFPE QKTLLVAHSN QALNQLFAKI VALDIDERHL LRLGHGEEEL ETEGSFSKHG RVESFLDNR QRFLYEVSRL AASMGAPGAH GNSAETAGYF NKVYVEPAWA KFNDIIQRED VGPEDIVRAF PFHAYFSDAP Q PLFPPEAD RETVLEIANG CYRHISKIFE ELADVLPFEI LRRDKDKANY LLTSEARIIA MTSTHAAMKR GEIASLGFQY DN VIMEEAA QITEIENFIP LALQKPKNGQ MALQRVVLCG DHYQNSPVIQ GLAFRHYANL EQSLFSRLVR LGVPTINLDQ QGR ARPSIS NLYRWRYPQL GDLPHTQTEP EFLTANAGFR YDYQFVNVPD YRGMGESEPT PHFIQNLGEA EYAVAIFQYM RLLG YPASK ISILATYAGQ KALIKDVLAH RCAKNPIFGL PRVVTTVDKY QGEQNDYIIL SLTRTTRVGY LRDLRRLTVA LSRAR LGLY ILGRRAVFES CYELRDAFSL LLRRPDKLAL VTGELWPSKR LLADETDDTK KLEGEVVMEG VEHLGQWVFE MTKTKI AEL RKEKGLSEEV PVEMPKEVVS AEADEGYLPL DEEEGDGEEG EGERVKGFEI EDS

UniProtKB: Pre-mRNA-splicing factor

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分子 #23: GPATCH1

分子名称: GPATCH1 / タイプ: protein_or_peptide / ID: 23 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 75.861016 KDa
配列文字列: MSHKRSRAAY EADLTAQQSP YVFFGTPLPP LDPDVRDDGS YVPIWKQEAR DERGRKRFHG AFTGGWSAGY FNTVGSKEGW TPSSFVSSR TKRWKDDPNK VEQRPEDFMD EEDLADLEES RKLQTREAFS GLGSTADDAV RASGLMGLFR VEGETMGVKL L KKMGWKEG ...文字列:
MSHKRSRAAY EADLTAQQSP YVFFGTPLPP LDPDVRDDGS YVPIWKQEAR DERGRKRFHG AFTGGWSAGY FNTVGSKEGW TPSSFVSSR TKRWKDDPNK VEQRPEDFMD EEDLADLEES RKLQTREAFS GLGSTADDAV RASGLMGLFR VEGETMGVKL L KKMGWKEG QGIGPKVRRK ARLGLGSDAN ITEETHLFAP DNVPMISFVR KTDHKGLGYA GETGLTPLSK ANGQNESDEE DE DDGGIGS LGRPRFSLTT ERKKGPQRPR GSIGVGILND TGSDDEDPYE LGPKISYNRV IGGDKQKKKT ATATNPTLKS KPT FVSSKS KALGKVALGV RKCHDGRLPL DGFVFGKEPD PLISEIIAEG KYPPPRIPPG WVSSKKPTSS AKQPAGYVST AEAA KSSTL DPRARAAILG EKQLPGKSVF DFLSPEARER LVAATGKKDL PPARGEVPAE YALSEDERLK KLLAQVPRLD KETAV AAIT RGASGAAPYA DDEAKRSRYL SFLEWQAGFK SSPGARTPKM KDDDWLRELH EFYNCARIFK PMTGFMASRF TTSSAA KPG SSSDGGASNN SCSQTPTKPQ DPTEEAAKLG MFGPMTRTVT EFYPSRLLCK RFGVNPPEHV RSDEYPANKS RFDASSI GG CSAASTGPTE EGTKPAWMPT GKAVVVVDPS RNEALEAKRA GEEVFKAVFG DSGDEG

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分子 #24: RNA helicase

分子名称: RNA helicase / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO / EC番号: RNA helicase
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 74.98975 KDa
配列文字列: MADSEVGGAF IPALYKPAAL LPIAKHRESL LYLVETNPVT IVVGQTGSGK STQIPQFLEK AGWCADGKLI AVTQPRRVAA VTLAIRVAE EFGCEVGKEV GYSIRFEDAT SESTRIKYMT DGLLIREALV DPLLSRYSVI MIDEAHERSI SSDILLGLLK K IRRKRPDL ...文字列:
MADSEVGGAF IPALYKPAAL LPIAKHRESL LYLVETNPVT IVVGQTGSGK STQIPQFLEK AGWCADGKLI AVTQPRRVAA VTLAIRVAE EFGCEVGKEV GYSIRFEDAT SESTRIKYMT DGLLIREALV DPLLSRYSVI MIDEAHERSI SSDILLGLLK K IRRKRPDL RIIISSATLQ AEDYRAYFEK ASETQEEDSS NDKQKESIAS IISIEGRTYP IDILYLDTPT EDYLEKAIST VF DIHTNEP KGDILVFLTG RDEIEQAVQA VSERSASLPP GSEALLPLPL YSGLSAEQQM YVFEEAPENT RKVIFSTNLA EAS VTIEGI VYVIDSGFVK LRAYNPKTGI ESLTATPVSK ASAAQRAGRA GRTKPGKCFR LYTEEAYQSL PDATVPEIQR SNLA PIILQ LKALGIDNVL RFDYFTPPPA EQMTRALELL YSLGALDDYA KLTRPLGLRM AELAVEPMMA KTLLSAQSFG CLSEI LTIA AMTSLDGTLW IQHEGDKKKT ESVKRKFAAE EGDHLTLLNV YQAFVTKGRK EAHWCHENML NYKAMIRAVS IRAQLK RFL ERFGIDVEES LSSPSVSQQP ANKAEKIQRC LTIGYFAHAA KMQPDGTFRN VSGTTVLHAH PSSIMFNRKA DWVIFHE VL ETKDKTFIRD ITRIKKEWLL EYAPDFYKTT

UniProtKB: RNA helicase

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分子 #25: Small nuclear ribonucleoprotein E

分子名称: Small nuclear ribonucleoprotein E / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 10.967812 KDa
配列文字列:
MTSRGAPAGR RVLLPPINFL FRLLQQRTPV QIWLYEQLAI RITGVIRGFD EFMNLVIDDA VEIKLSPKTN EPESKRPLGQ ILLKGDNIS LIQALSGSA

UniProtKB: Small nuclear ribonucleoprotein E

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分子 #26: Small nuclear ribonucleoprotein G

分子名称: Small nuclear ribonucleoprotein G / タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 9.259763 KDa
配列文字列:
MAPAQPELKK YLDKRLFVEL NGSRRVIGVL RGYDVFLNIV LDDAVEERPN GEKVKLGMVT IRGNSVVILE PLERIGDDRP GR

UniProtKB: Small nuclear ribonucleoprotein G

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分子 #27: Sm protein F

分子名称: Sm protein F / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 10.727227 KDa
配列文字列:
MNTGFVPVNP RPFLQDLVNQ DVIVRLKWGQ TEYKGRLVSI DSYMNIQLAN TEEFINYKST GHLGQVLIRC NNVLWVTAAA GKQMTPTED TKMEE

UniProtKB: Sm protein F

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分子 #28: Delta(14)-sterol reductase

分子名称: Delta(14)-sterol reductase / タイプ: protein_or_peptide / ID: 28 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 66.785492 KDa
配列文字列: MAPKTKKQAV SRTQHYEFFG PPGAAAISFG LPLLVYAFAF ACNDITGCPA PSLLHPKSLK LDVLKQEVGW PKNGIWGLAS WRVTGWTLA YYLWLALLYR ILPGDVVEGT QLRNGGRLKY KLNAFASSMF TLVICAAGTI AQGADFPLWT FIADNYVQIL T ANVIIAYT ...文字列:
MAPKTKKQAV SRTQHYEFFG PPGAAAISFG LPLLVYAFAF ACNDITGCPA PSLLHPKSLK LDVLKQEVGW PKNGIWGLAS WRVTGWTLA YYLWLALLYR ILPGDVVEGT QLRNGGRLKY KLNAFASSMF TLVICAAGTI AQGADFPLWT FIADNYVQIL T ANVIIAYT LATFVYIRSF SVKPGNPQLR ELAVGGVTGN ILYDWFIGRE LNPRVTLPII GEIDIKQWME LRPGLLGWTL MN CAFVAKQ YRLYGYVTDS IVFVTAVQAL YVLDSHYFEP AVLTTIDITT DGFGLMLSFG DIVWVPFIYT QSTRYLAVHP QKL GYLGLV GVTVLLVAGF AIFRLSNSQK NAFRTNPNDP SVKHLKYIET KAGTRLLISG WWGIARHINY LGDWLQAWPY CLPT GLAGY QILTAGSELA EGAVKMLDGR IVVPGEARGW GTIFTYFYVV YFATLLLHRD RRDDEKCSKK YGEDWEKYKE IVRWR IIPA LLQKPRSECT EWEIAQIEEW EMANGPLSLL QTAVRSHTQV LISVRSGRKL LARVKAFDRH CNMILENVKE MWTETP VTN GKKGRPVNKD RFISKMFLRG DSVVIVLLS

UniProtKB: Delta(14)-sterol reductase

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分子 #29: Small nuclear ribonucleoprotein Sm D1

分子名称: Small nuclear ribonucleoprotein Sm D1 / タイプ: protein_or_peptide / ID: 29 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 13.033093 KDa
配列文字列:
MKLVRFLMKC ANETVTIELK NGAIVHGTIA SVTPKMDTAL RNVRYTPKGE EPYSVESLTV RGNTIRYYIL PDSLPLDTLL IDDAPKPKN KARKEADRGR GRGRGRGGRG GRGGRARGR

UniProtKB: Small nuclear ribonucleoprotein Sm D1

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分子 #30: Sm protein B

分子名称: Sm protein B / タイプ: protein_or_peptide / ID: 30 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 21.425543 KDa
配列文字列: MSSSQNRQGK MAGYINWRMR VTLNDGRQMT GQMLAFDKHM NLVLADTEEF RKTKRMQAKP NSSTTQTLIQ EEKRTLGLTI VRGANIIAL SVESPPPADP SARLGKTTGA GIASTLTAGP GVARPAGRGA AAPISLAGPA PGVGGAVPPP PFPGFPAAAP P GFPGRGGP ...文字列:
MSSSQNRQGK MAGYINWRMR VTLNDGRQMT GQMLAFDKHM NLVLADTEEF RKTKRMQAKP NSSTTQTLIQ EEKRTLGLTI VRGANIIAL SVESPPPADP SARLGKTTGA GIASTLTAGP GVARPAGRGA AAPISLAGPA PGVGGAVPPP PFPGFPAAAP P GFPGRGGP APPGFPAAPF PPPAGFPGAP GFPPGFPPGG APPPAGFNPP PRR

UniProtKB: Sm protein B

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分子 #31: Small nuclear ribonucleoprotein Sm D3

分子名称: Small nuclear ribonucleoprotein Sm D3 / タイプ: protein_or_peptide / ID: 31 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 12.70868 KDa
配列文字列:
MTSSIGIPIK LLNEAQGHIV TLELTTGQTY RGKLIEAEDN MNVQLKDITV TARDGRVSHL EQIYIRGSHV RFFIVPDMLR NAPMFRSRN VRGRGVGLAR GRATVSRARA SGRGR

UniProtKB: Small nuclear ribonucleoprotein Sm D3

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分子 #32: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 32 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 26.329277 KDa
配列文字列: MSDNVGLPTP RGSGTSGYVQ RNLAHLRPRE PIKPRDPESY RHKPRKPDPG LLEHDRKREV EVKVFELRDK LEEEGVDEEE IESRCSELR QKLLAEMERN KDALPAQRKT FKAHQVHEAA DAKLKESERL RQALKISKDY EEGSHWRRQE ERKKPLERGD L PPGVADRE ...文字列:
MSDNVGLPTP RGSGTSGYVQ RNLAHLRPRE PIKPRDPESY RHKPRKPDPG LLEHDRKREV EVKVFELRDK LEEEGVDEEE IESRCSELR QKLLAEMERN KDALPAQRKT FKAHQVHEAA DAKLKESERL RQALKISKDY EEGSHWRRQE ERKKPLERGD L PPGVADRE KERERGRERG RDGDRNGDRY RQRDDDRYQP EPEPEQKQEQ KQKLEQKSSA WAGSV

UniProtKB: Putative pre-mRNA splicing protein

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分子 #33: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 33 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 76.518102 KDa
配列文字列: MASADSAAAA AKTEEQKLAE QRAEYQKLLE LRSQGVYLPP HKLRALQAAI TDPKTKEYQR IAWDALKKSI NGLVNKVNTA NIKHVVPEL FNENLIRGRG LFCQSLLKAQ HASLPFTPIY ACMAAIVNTK LPQVGELLVK RLIMRFRKAF KRNDKPVCLS S TMFIAHLV ...文字列:
MASADSAAAA AKTEEQKLAE QRAEYQKLLE LRSQGVYLPP HKLRALQAAI TDPKTKEYQR IAWDALKKSI NGLVNKVNTA NIKHVVPEL FNENLIRGRG LFCQSLLKAQ HASLPFTPIY ACMAAIVNTK LPQVGELLVK RLIMRFRKAF KRNDKPVCLS S TMFIAHLV NQQVVHETLA GQILVLLLQK PTDDSVEIAV GFMREVGLFL EEMAPRIAHI VFDQFKNILH EADIDRRTQY MI EVLFQIR KDRYKDNPVI KEELDLIEEE DQITHRISLD EDINTEDSLN IFKYDPEWEE NENEYKKLKA EILGEVSGDE DEE DEDEED EESEESEDEE QKAIEIRDQT NADLVNLRRT IYLTIQSSAD PEEAAHKLMK LKLPPGQEPE LVSMIIESCA QEKV YSKFM GLLGEKFARL NRMWMELYEE AFTKYYNTIH RYETNKLRNI ARFFGHLLSY DAIGWHVLSV IQLTEEETTA ASRIF IRFL FEDIQENLGT AKLKARLGDE ALQPYLEGIF RHDTRRNVTF AINYFTAIKM GYLTDEMHPG RHHGRGLGPE VALRRV PLF VGPDPTAGAG AGAGTGAAGA TPAAPAGAEA APEIIPALFP QEVGADPSLA RFLAHHPLVV KQESLTGAVS GSKEAEK VE VEVEVEVKVE DTAEARRAVQ QVSVAVKVPI EVCVPP

UniProtKB: Putative pre-mRNA splicing protein

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分子 #34: Nineteen complex-related protein 2-domain-containing protein

分子名称: Nineteen complex-related protein 2-domain-containing protein
タイプ: protein_or_peptide / ID: 34 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 56.472395 KDa
配列文字列: MAAFGAKRKP RIIKAFDDDD EDLSLPLSSG GEDKQAGEEL PPPARIKFGR TKFTKSSALR KNAMIGNDDT DSPNATSARD DDDDDENSG APVVVRPSSV NKGSLSKIKK RPAASRLSFG PSAGAEDDDE EAEVVIQPRK MLNQRAVENS ALRANSSLPT R FGGEENRP ...文字列:
MAAFGAKRKP RIIKAFDDDD EDLSLPLSSG GEDKQAGEEL PPPARIKFGR TKFTKSSALR KNAMIGNDDT DSPNATSARD DDDDDENSG APVVVRPSSV NKGSLSKIKK RPAASRLSFG PSAGAEDDDE EAEVVIQPRK MLNQRAVENS ALRANSSLPT R FGGEENRP KYSKEYLAEL QSATFNTPQN LADLKIHDDD EMQLDEMELE GALIVPSNEV AVPGASTTQT THIPTEAEIR ER KERRARL AHEAKFIPLD DEFNSDNEGA QPSHPILNLP SKQKRRDTRL IREDEDLYEG FDEFVSDGNL ALGRKAEKAV LQR HRQEMA ELIEAAQAED NDEAASDDSE AEERAAYEEA QVRAAMDGLR GKYREEHLER GGGADLYEGR GPDDIPRMKP LPKL GDVLQ RIREAIQGLE GEVVRKRSRI EGLEKEKAEI LVREKEVQEI LNQAGQKYQE VVGGLGVHNV PKIVAGQSPL RPFPP GLAR EMPTERGLES YGATPIRRYG GEEDDG

UniProtKB: Nineteen complex-related protein 2-domain-containing protein

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分子 #35: GCFC2

分子名称: GCFC2 / タイプ: protein_or_peptide / ID: 35 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 5.634938 KDa
配列文字列: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) ...文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

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分子 #36: TFIP11

分子名称: TFIP11 / タイプ: protein_or_peptide / ID: 36 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 59.591422 KDa
配列文字列: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) ...文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)

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分子 #38: Putative pre-mRNA splicing protein

分子名称: Putative pre-mRNA splicing protein / タイプ: protein_or_peptide / ID: 38 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (菌類)
分子量理論値: 28.376967 KDa
配列文字列: MARNSEKAQS MLFRFREAQA ADLGIIDAGR ARRPRVITEV DSIPACEKWR GQVLKEISRK VSRIQDPALS DYQIRDLNDE INKLMREKH MWEVQIRNLG GPNYMRGGGK VYDEAGREIP GAGRGYRYFG RARELPGVKE LFEAAAKAKR EEEEKPLEER A DLRRQVNA ...文字列:
MARNSEKAQS MLFRFREAQA ADLGIIDAGR ARRPRVITEV DSIPACEKWR GQVLKEISRK VSRIQDPALS DYQIRDLNDE INKLMREKH MWEVQIRNLG GPNYMRGGGK VYDEAGREIP GAGRGYRYFG RARELPGVKE LFEAAAKAKR EEEEKPLEER A DLRRQVNA AYYGYAPGEE DDELLEYERA REEQARKALQ KAGPPDAPPG WEPLPGDTGD GRVWELPTLE EVQRELIERR RQ RLLDQL

UniProtKB: Putative pre-mRNA splicing protein

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分子 #39: N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)

分子名称: N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)
タイプ: ligand / ID: 39 / コピー数: 1 / 式: M7M
分子量理論値: 487.296 Da
Chemical component information

ChemComp-M7M:
N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate)

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分子 #40: MAGNESIUM ION

分子名称: MAGNESIUM ION / タイプ: ligand / ID: 40 / コピー数: 1 / 式: MG
分子量理論値: 24.305 Da

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分子 #41: GUANOSINE-5'-TRIPHOSPHATE

分子名称: GUANOSINE-5'-TRIPHOSPHATE / タイプ: ligand / ID: 41 / コピー数: 1 / 式: GTP
分子量理論値: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP / GTP, エネルギー貯蔵分子*YM

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分子 #42: ZINC ION

分子名称: ZINC ION / タイプ: ligand / ID: 42 / コピー数: 4 / 式: ZN
分子量理論値: 65.409 Da

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 7.4
凍結凍結剤: ETHANE

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電子顕微鏡法

顕微鏡TFS KRIOS
撮影フィルム・検出器のモデル: FEI FALCON IV (4k x 4k)
平均電子線量: 50.0 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / 最大 デフォーカス（公称値）: 2.5 µm / 最小 デフォーカス（公称値）: 1.0 µm
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

初期モデルモデルのタイプ: PDB ENTRY
PDBモデル - PDB ID:

5y88

最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 2.9 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 66478
初期 角度割当タイプ: OTHER / ソフトウェア - 名称: RELION / 詳細: Relion
最終 角度割当タイプ: OTHER / ソフトウェア - 名称: RELION / 詳細: Relion
FSC曲線 (解像度の算出)

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る