Entry Database : EMDB / ID : EMD-60384 Downloads & linksTitle Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex Map data Details SampleComplex : The complex of GPR15L(C11)-bound GPR15-GiProtein or peptide : Guanine nucleotide-binding protein G(i) subunit alpha-1Protein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Protein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Protein or peptide : scFv16Protein or peptide : GPR15Protein or peptide : Protein GPR15LG Show more 2 items Show less Details Keywords Cryo-EM / GPCR / GPR15L / GPR15 / MEMBRANE PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
regulation of keratinocyte proliferation / regulation of T cell migration / negative regulation of cell cycle G1/S phase transition / lymphocyte chemotaxis / negative regulation of cell division / chemokine activity / mast cell degranulation / T cell homeostasis / Adenylate cyclase inhibitory pathway / positive regulation of protein localization to cell cortex ... regulation of keratinocyte proliferation / regulation of T cell migration / negative regulation of cell cycle G1/S phase transition / lymphocyte chemotaxis / negative regulation of cell division / chemokine activity / mast cell degranulation / T cell homeostasis / Adenylate cyclase inhibitory pathway / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / defense response to fungus / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / Regulation of insulin secretion / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / Olfactory Signaling Pathway / Activation of the phototransduction cascade / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / G-protein activation / G protein-coupled acetylcholine receptor signaling pathway / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / G beta:gamma signalling through CDC42 / response to peptide hormone / ADP signalling through P2Y purinoceptor 12 / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Sensory perception of sweet, bitter, and umami (glutamate) taste / photoreceptor disc membrane / Adrenaline,noradrenaline inhibits insulin secretion / Glucagon-type ligand receptors / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / cellular response to catecholamine stimulus / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / ADORA2B mediated anti-inflammatory cytokines production / sensory perception of taste / ADP signalling through P2Y purinoceptor 1 / adenylate cyclase-activating dopamine receptor signaling pathway / G beta:gamma signalling through PI3Kgamma / cellular response to prostaglandin E stimulus / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / GPER1 signaling / GDP binding / Inactivation, recovery and regulation of the phototransduction cascade / heterotrimeric G-protein complex / G alpha (12/13) signalling events / extracellular vesicle / signaling receptor complex adaptor activity / Thrombin signalling through proteinase activated receptors (PARs) / GTPase binding / retina development in camera-type eye / phospholipase C-activating G protein-coupled receptor signaling pathway / Ca2+ pathway / cell cortex / midbody / G alpha (i) signalling events / G alpha (s) signalling events / G alpha (q) signalling events / cell population proliferation / cell cycle / Ras protein signal transduction / Extra-nuclear estrogen signaling / receptor ligand activity / defense response to Gram-positive bacterium / G protein-coupled receptor signaling pathway / cell division / lysosomal membrane / GTPase activity / centrosome / synapse / protein-containing complex binding / GTP binding / nucleolus / magnesium ion binding / signal transduction / extracellular space / extracellular exosome / extracellular region / nucleoplasm / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function G-protein coupled receptor ligand 15 / G-protein coupled receptor ligand 15 / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit ... G-protein coupled receptor ligand 15 / G-protein coupled receptor ligand 15 / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / Guanine nucleotide-binding protein G(i) subunit alpha-1 / Protein GPR15LG Similarity search - ComponentBiological species Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 2.9 Å Details AuthorsZhang ZY / Zheng Y / Xu F Funding support China, 1 items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 32071194 China
CitationJournal : Cell Discov / Year : 2024Title : Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15.Authors : Zhongyuan Zhang / You Zheng / Lu Xu / Yang Yue / Kexin Xu / Fei Li / Fei Xu / History Deposition Jun 2, 2024 - Header (metadata) release Jul 10, 2024 - Map release Jul 10, 2024 - Update Jul 10, 2024 - Current status Jul 10, 2024 Processing site : PDBj / Status : Released
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