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- EMDB-51358: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 fr... -

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Basic information

Entry
Database: EMDB / ID: EMD-51358
TitleStructure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)
Map dataStructure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2
Sample
  • Tissue: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)
Keywordsheteromeric amyloid filament / PROTEIN FIBRIL
Biological speciesHomo sapiens (human)
Methodhelical reconstruction / cryo EM / Resolution: 2.8 Å
AuthorsArseni D
Funding support United Kingdom, 1 items
OrganizationGrant numberCountry
Medical Research Council (MRC, United Kingdom) United Kingdom
CitationJournal: To Be Published
Title: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)
Authors: Arseni D
History
DepositionAug 15, 2024-
Header (metadata) releaseAug 27, 2025-
Map releaseAug 27, 2025-
UpdateAug 27, 2025-
Current statusAug 27, 2025Processing site: PDBe / Status: Released

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Structure visualization

Supplemental images

emd_51358.png

Downloads & links

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Map

FileDownload / File: emd_51358.map.gz / Format: CCP4 / Size: 64 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationStructure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2
Projections & slices

Image control

Size
Brightness
Contrast
Others
AxesZ (Sec.)Y (Row.)X (Col.)
0.83 Å/pix.
x 256 pix.
= 212.48 Å		0.83 Å/pix.
x 256 pix.
= 212.48 Å		0.83 Å/pix.
x 256 pix.
= 212.48 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 0.83 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 0.0122
Minimum - Maximum-0.023210201 - 0.04666105
Average (Standard dev.)0.00031130787 (±0.002812644)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions256256256
Spacing256256256
CellA=B=C: 212.48 Å
α=β=γ: 90.0 °

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Supplemental data

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Half map: Structure of heteromeric amyloid filament of TDP-43 and...

Fileemd_51358_half_map_1.map
AnnotationStructure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Half map: Structure of heteromeric amyloid filament of TDP-43 and...

Fileemd_51358_half_map_2.map
AnnotationStructure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2
Projections & Slices
AxesZYX

Projections

Slices (1/2)
Density Histograms

Histogram

Histogram (log scale)

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Sample components

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Entire : Structure of heteromeric amyloid filament of TDP-43 and AXNA11 fr...

EntireName: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)
Components
  • Tissue: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)

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Supramolecule #1: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 fr...

SupramoleculeName: Structure of heteromeric amyloid filament of TDP-43 and AXNA11 from FTLD-TDP Type C individual 2 (variant 1)
type: tissue / ID: 1 / Parent: 0
Source (natural)Organism: Homo sapiens (human)

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Experimental details

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Structure determination

Methodcryo EM
Processinghelical reconstruction
Aggregation statefilament

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 38.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.2 µm / Nominal defocus min: 1.0 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Final reconstructionApplied symmetry - Helical parameters - Δz: 4.81 Å
Applied symmetry - Helical parameters - Δ&Phi: -1.82 °
Applied symmetry - Helical parameters - Axial symmetry: C1 (asymmetric)
Resolution.type: BY AUTHOR / Resolution: 2.8 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: RELION (ver. 5) / Number images used: 8236
CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
Startup modelType of model: OTHER
Final angle assignmentType: NOT APPLICABLE

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