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基本情報
登録情報 | ![]() | |||||||||
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タイトル | Cryo-EM structure of human Low-density lipoprotein receptor-related protein 2 | |||||||||
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![]() | human / kidney / Low-density lipoprotein receptor-related protein 2 / LRP2 / MEMBRANE PROTEIN | |||||||||
機能・相同性 | ![]() Transport of RCbl within the body / diol metabolic process / positive regulation of oligodendrocyte progenitor proliferation / pulmonary artery morphogenesis / secondary heart field specification / positive regulation of lysosomal protein catabolic process / folate import across plasma membrane / cobalamin transport / protein transporter activity / ventricular compact myocardium morphogenesis ...Transport of RCbl within the body / diol metabolic process / positive regulation of oligodendrocyte progenitor proliferation / pulmonary artery morphogenesis / secondary heart field specification / positive regulation of lysosomal protein catabolic process / folate import across plasma membrane / cobalamin transport / protein transporter activity / ventricular compact myocardium morphogenesis / response to leptin / Vitamin D (calciferol) metabolism / low-density lipoprotein particle receptor activity / metal ion transport / transcytosis / vitamin D metabolic process / cranial skeletal system development / neuron projection arborization / coronary artery morphogenesis / insulin-like growth factor I binding / outflow tract septum morphogenesis / positive regulation of neurogenesis / cargo receptor activity / aorta development / ventricular septum development / amyloid-beta clearance / hormone binding / vagina development / negative regulation of BMP signaling pathway / forebrain development / transport across blood-brain barrier / retinoid metabolic process / Retinoid metabolism and transport / clathrin-coated pit / receptor-mediated endocytosis / endosome lumen / neural tube closure / phosphatidylinositol 3-kinase/protein kinase B signal transduction / brush border membrane / kidney development / sensory perception of sound / clathrin-coated endocytic vesicle membrane / cellular response to growth factor stimulus / SH3 domain binding / lipid metabolic process / endocytosis / male gonad development / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / protein transport / protein-folding chaperone binding / gene expression / lysosome / cell population proliferation / receptor complex / apical plasma membrane / axon / lysosomal membrane / external side of plasma membrane / dendrite / calcium ion binding / negative regulation of apoptotic process / endoplasmic reticulum / Golgi apparatus / extracellular exosome / plasma membrane 類似検索 - 分子機能 | |||||||||
生物種 | ![]() | |||||||||
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.3 Å | |||||||||
![]() | Zhang Z / Lyu M | |||||||||
資金援助 | ![]()
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![]() | ![]() タイトル: Cryo-EM structure of human Low-density lipoprotein receptor-related protein 2 著者: Zhang Z / Lyu M | |||||||||
履歴 |
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構造の表示
添付画像 |
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画像 | ![]() | 76.8 KB | ||
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文書・詳細版 | ![]() | 513.1 KB | 表示 | |
XML形式データ | ![]() | 7.9 KB | 表示 | |
CIF形式データ | ![]() | 9.4 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
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EMDBのページ | ![]() ![]() |
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「今月の分子」の関連する項目 |
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ファイル | ![]() | ||||||||||||||||||||||||||||||||||||
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投影像・断面図 | 画像のコントロール
画像は Spider により作成 | ||||||||||||||||||||||||||||||||||||
ボクセルのサイズ | X=Y=Z: 1.07 Å | ||||||||||||||||||||||||||||||||||||
密度 |
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対称性 | 空間群: 1 | ||||||||||||||||||||||||||||||||||||
詳細 | EMDB XML:
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-添付データ
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試料の構成要素
-全体 : Low-density lipoprotein receptor-related protein 2
全体 | 名称: Low-density lipoprotein receptor-related protein 2 |
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要素 |
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-超分子 #1: Low-density lipoprotein receptor-related protein 2
超分子 | 名称: Low-density lipoprotein receptor-related protein 2 / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1 |
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由来(天然) | 生物種: ![]() |
-分子 #1: Low-density lipoprotein receptor-related protein 2
分子 | 名称: Low-density lipoprotein receptor-related protein 2 / タイプ: protein_or_peptide / ID: 1 / コピー数: 2 / 光学異性体: LEVO |
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由来(天然) | 生物種: ![]() |
分子量 | 理論値: 522.502562 KDa |
配列 | 文字列: MDRGPAAVAC TLLLALVACL APASGQECDS AHFRCGSGHC IPADWRCDGT KDCSDDADEI GCAVVTCQQG YFKCQSEGQC IPNSWVCDQ DQDCDDGSDE RQDCSQSTCS SHQITCSNGQ CIPSEYRCDH VRDCPDGADE NDCQYPTCEQ LTCDNGACYN T SQKCDWKV ...文字列: MDRGPAAVAC TLLLALVACL APASGQECDS AHFRCGSGHC IPADWRCDGT KDCSDDADEI GCAVVTCQQG YFKCQSEGQC IPNSWVCDQ DQDCDDGSDE RQDCSQSTCS SHQITCSNGQ CIPSEYRCDH VRDCPDGADE NDCQYPTCEQ LTCDNGACYN T SQKCDWKV DCRDSSDEIN CTEICLHNEF SCGNGECIPR AYVCDHDNDC QDGSDEHACN YPTCGGYQFT CPSGRCIYQN WV CDGEDDC KDNGDEDGCE SGPHDVHKCS PREWSCPESG RCISIYKVCD GILDCPGRED ENNTSTGKYC SMTLCSALNC QYQ CHETPY GGACFCPPGY IINHNDSRTC VEFDDCQIWG ICDQKCESRP GRHLCHCEEG YILERGQYCK ANDSFGEASI IFSN GRDLL IGDIHGRSFR ILVESQNRGV AVGVAFHYHL QRVFWTDTVQ NKVFSVDING LNIQEVLNVS VETPENLAVD WVNNK IYLV ETKVNRIDMV NLDGSYRVTL ITENLGHPRG IAVDPTVGYL FFSDWESLSG EPKLERAFMD GSNRKDLVKT KLGWPA GVT LDMISKRVYW VDSRFDYIET VTYDGIQRKT VVHGGSLIPH PFGVSLFEGQ VFFTDWTKMA VLKANKFTET NPQVYYQ AS LRPYGVTVYH SLRQPYATNP CKDNNGGCEQ VCVLSHRTDN DGLGFRCKCT FGFQLDTDER HCIAVQNFLI FSSQVAIR G IPFTLSTQED VMVPVSGNPS FFVGIDFDAQ DSTIFFSDMS KHMIFKQKID GTGREILAAN RVENVESLAF DWISKNLYW TDSHYKSISV MRLADKTRRT VVQYLNNPRS VVVHPFAGYL FFTDWFRPAK IMRAWSDGSH LLPVINTTLG WPNGLAIDWA ASRLYWVDA YFDKIEHSTF DGLDRRRLGH IEQMTHPFGL AIFGEHLFFT DWRLGAIIRV RKADGGEMTV IRSGIAYILH L KSYDVNIQ TGSNACNQPT HPNGDCSHFC FPVPNFQRVC GCPYGMRLAS NHLTCEGDPT NEPPTEQCGL FSFPCKNGRC VP NYYLCDG VDDCHDNSDE QLCGTLNNTC SSSAFTCGHG ECIPAHWRCD KRNDCVDGSD EHNCPTHAPA SCLDTQYTCD NHQ CISKNW VCDTDNDCGD GSDEKNCNST ETCQPSQFNC PNHRCIDLSF VCDGDKDCVD GSDEVGCVLN CTASQFKCAS GDKC IGVTN RCDGVFDCSD NSDEAGCPTR PPGMCHSDEF QCQEDGICIP NFWECDGHPD CLYGSDEHNA CVPKTCPSSY FHCDN GNCI HRAWLCDRDN DCGDMSDEKD CPTQPFRCPS WQWQCLGHNI CVNLSVVCDG IFDCPNGTDE SPLCNGNSCS DFNGGC THE CVQEPFGAKC LCPLGFLLAN DSKTCEDIDE CDILGSCSQH CYNMRGSFRC SCDTGYMLES DGRTCKVTAS ESLLLLV AS QNKIIADSVT SQVHNIYSLV ENGSYIVAVD FDSISGRIFW SDATQGKTWS AFQNGTDRRV VFDSSIILTE TIAIDWVG R NLYWTDYALE TIEVSKIDGS HRTVLISKNL TNPRGLALDP RMNEHLLFWS DWGHHPRIER ASMDGSMRTV IVQDKIFWP CGLTIDYPNR LLYFMDSYLD YMDFCDYNGH HRRQVIASDL IIRHPYALTL FEDSVYWTDR ATRRVMRANK WHGGNQSVVM YNIQWPLGI VAVHPSKQPN SVNPCAFSRC SHLCLLSSQG PHFYSCVCPS GWSLSPDLLN CLRDDQPFLI TVRQHIIFGI S LNPEVKSN DAMVPIAGIQ NGLDVEFDDA EQYIYWVENP GEIHRVKTDG TNRTVFASIS MVGPSMNLAL DWISRNLYST NP RTQSIEV LTLHGDIRYR KTLIANDGTA LGVGFPIGIT VDPARGKLYW SDQGTDSGVP AKIASANMDG TSVKTLFTGN LEH LECVTL DIEEQKLYWA VTGRGVIERG NVDGTDRMIL VHQLSHPWGI AVHDSFLYYT DEQYEVIERV DKATGANKIV LRDN VPNLR GLQVYHRRNA AESSNGCSNN MNACQQICLP VPGGLFSCAC ATGFKLNPDN RSCSPYNSFI VVSMLSAIRG FSLEL SDHS ETMVPVAGQG RNALHVDVDV SSGFIYWCDF SSSVASDNAI RRIKPDGSSL MNIVTHGIGE NGVRGIAVDW VAGNLY FTN AFVSETLIEV LRINTTYRRV LLKVTVDMPR HIVVDPKNRY LFWADYGQRP KIERSFLDCT NRTVLVSEGI VTPRGLA VD RSDGYVYWVD DSLDIIARIR INGENSEVIR YGSRYPTPYG ITVFENSIIW VDRNLKKIFQ ASKEPENTEP PTVIRDNI N WLRDVTIFDK QVQPRSPAEV NNNPCLENNG GCSHLCFALP GLHTPKCDCA FGTLQSDGKN CAISTENFLI FALSNSLRS LHLDPENHSP PFQTINVERT VMSLDYDSVS DRIYFTQNLA SGVGQISYAT LSSGIHTPTV IASGIGTADG IAFDWITRRI YYSDYLNQM INSMAEDGSN RTVIARVPKP RAIVLDPCQG YLYWADWDTH AKIERATLGG NFRVPIVNSS LVMPSGLTLD Y EEDLLYWV DASLQRIERS TLTGVDREVI VNAAVHAFGL TLYGQYIYWT DLYTQRIYRA NKYDGSGQIA MTTNLLSQPR GI NTVVKNQ KQQCNNPCEQ FNGGCSHICA PGPNGAECQC PHEGNWYLAN NRKHCIVDNG ERCGASSFTC SNGRCISEEW KCD NDNDCG DGSDEMESVC ALHTCSPTAF TCANGRCVQY SYRCDYYNDC GDGSDEAGCL FRDCNATTEF MCNNRRCIPR EFIC NGVDN CHDNNTSDEK NCPDRTCQSG YTKCHNSNIC IPRVYLCDGD NDCGDNSDEN PTYCTTHTCS SSEFQCASGR CIPQH WYCD QETDCFDASD EPASCGHSER TCLADEFKCD GGRCIPSEWI CDGDNDCGDM SDEDKRHQCQ NQNCSDSEFL CVNDRP PDR RCIPQSWVCD GDVDCTDGYD ENQNCTRRTC SENEFTCGYG LCIPKIFRCD RHNDCGDYSD ERGCLYQTCQ QNQFTCQ NG RCISKTFVCD EDNDCGDGSD ELMHLCHTPE PTCPPHEFKC DNGRCIEMMK LCNHLDDCLD NSDEKGCGIN ECHDPSIS G CDHNCTDTLT SFYCSCRPGY KLMSDKRTCV DIDECTEMPF VCSQKCENVI GSYICKCAPG YLREPDGKTC RQNSNIEPY LIFSNRYYLR NLTIDGYFYS LILEGLDNVV ALDFDRVEKR LYWIDTQRQV IERMFLNKTN KETIINHRLP AAESLAVDWV SRKLYWLDA RLDGLFVSDL NGGHRRMLAQ HCVDANNTFC FDNPRGLALH PQYGYLYWAD WGHRAYIGRV GMDGTNKSVI I STKLEWPN GITIDYTNDL LYWADAHLGY IEYSDLEGHH RHTVYDGALP HPFAITIFED TIYWTDWNTR TVEKGNKYDG SN RQTLVNT THRPFDIHVY HPYRQPIVSN PCGTNNGGCS HLCLIKPGGK GFTCECPDDF RTLQLSGSTY CMPMCSSTQF LCA NNEKCI PIWWKCDGQK DCSDGSDELA LCPQRFCRLG QFQCSDGNCT SPQTLCNAHQ NCPDGSDEDR LLCENHHCDS NEWQ CANKR CIPESWQCDT FNDCEDNSDE DSSHCASRTC RPGQFRCANG RCIPQAWKCD VDNDCGDHSD EPIEECMSSA HLCDN FTEF SCKTNYRCIP KWAVCNGVDD CRDNSDEQGC EERTCHPVGD FRCKNHHCIP LRWQCDGQND CGDNSDEENC APRECT ESE FRCVNQQCIP SRWICDHYND CGDNSDERDC EMRTCHPEYF QCTSGHCVHS ELKCDGSADC LDASDEADCP TRFPDGA YC QATMFECKNH VCIPPYWKCD GDDDCGDGSD EELHLCLDVP CNSPNRFRCD NNRCIYSHEV CNGVDDCGDG TDETEEHC R KPTPKPCTEY EYKCGNGHCI PHDNVCDDAD DCGDWSDELG CNKGKERTCA ENICEQNCTQ LNEGGFICSC TAGFETNVF DRTSCLDINE CEQFGTCPQH CRNTKGSYEC VCADGFTSMS DRPGKRCAAE GSSPLLLLPD NVRIRKYNLS SERFSEYLQD EEYIQAVDY DWDPKDIGLS VVYYTVRGEG SRFGAIKRAY IPNFESGRNN LVQEVDLKLK YVMQPDGIAV DWVGRHIYWS D VKNKRIEV AKLDGRYRKW LISTDLDQPA AIAVNPKLGL MFWTDWGKEP KIESAWMNGE DRNILVFEDL GWPTGLSIDY LN NDRIYWS DFKEDVIETI KYDGTDRRVI AKEAMNPYSL DIFEDQLYWI SKEKGEVWKQ NKFGQGKKEK TLVVNPWLTQ VRI FHQLRY NKSVPNLCKQ ICSHLCLLRP GGYSCACPQG SSFIEGSTTE CDAAIELPIN LPPPCRCMHG GNCYFDETDL PKCK CPSGY TGKYCEMAFS KGISPGTTAV AVLLTILLIV VIGALAIAGF FHYRRTGSLL PALPKLPSLS SLVKPSENGN GVTFR SGAD LNMDIGVSGF GPETAIDRSM AMSEDFVMEM GKQPIIFENP MYSARDSAVK VVQPIQVTVS ENVDNKNYGS PINPSE IVP ETNPTSPAAD GTQVTKWNLF KRKSKQTTNF ENPIYAQMEN EQKESVAATP PPSPSLPAKP KPPSRRDPTP TYSATED TF KDTANLVKED SEV UniProtKB: Low-density lipoprotein receptor-related protein 2 |
-分子 #4: 2-acetamido-2-deoxy-beta-D-glucopyranose
分子 | 名称: 2-acetamido-2-deoxy-beta-D-glucopyranose / タイプ: ligand / ID: 4 / コピー数: 23 / 式: NAG |
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分子量 | 理論値: 221.208 Da |
Chemical component information | ![]() ChemComp-NAG: |
-実験情報
-構造解析
手法 | クライオ電子顕微鏡法 |
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![]() | 単粒子再構成法 |
試料の集合状態 | particle |
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試料調製
緩衝液 | pH: 7.5 |
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凍結 | 凍結剤: ETHANE |
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電子顕微鏡法
顕微鏡 | FEI TITAN KRIOS |
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撮影 | フィルム・検出器のモデル: GATAN K3 BIOQUANTUM (6k x 4k) 平均電子線量: 40.0 e/Å2 |
電子線 | 加速電圧: 300 kV / 電子線源: ![]() |
電子光学系 | 照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / 最大 デフォーカス(公称値): 1.5 µm / 最小 デフォーカス(公称値): 0.8 µm / 倍率(公称値): 81000 |
実験機器 | ![]() モデル: Titan Krios / 画像提供: FEI Company |