EMDB-45757: Human 39S mitoribosome in complex with antibiotic Linezolid

Basic information

Entry

Database: EMDB / ID: EMD-45757

• Title: Human 39S mitoribosome in complex with antibiotic Linezolid

Sample

• Complex: 39S subunit of human mitochondrial ribosome in complex with Linezolid
  • Protein or peptide: x 52 types
  • RNA: x 2 types
• Ligand: x 4 types

• Keywords: Mitochondrial ribosome / Oxazolidinone / antibiotics / RIBOSOME-ANTIBIOTIC complex

Function / homology

Function:

mitochondrial transcription / mitochondrial translational termination / mitochondrial translational elongation / translation release factor activity, codon nonspecific / Mitochondrial translation elongation / Mitochondrial translation termination / Mitochondrial translation initiation / translation release factor activity / mitochondrial large ribosomal subunit / peptidyl-tRNA hydrolase / mitochondrial ribosome / Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters / mitochondrial small ribosomal subunit / peptidyl-tRNA hydrolase activity / mitochondrial translation / anatomical structure morphogenesis / RNA processing / rescue of stalled ribosome / Mitochondrial protein degradation / cellular response to leukemia inhibitory factor / fibrillar center / cell junction / large ribosomal subunit / double-stranded RNA binding / large ribosomal subunit rRNA binding / small ribosomal subunit rRNA binding / endonuclease activity / mitochondrial inner membrane / negative regulation of translation / rRNA binding / nuclear body / ribosome / structural constituent of ribosome / mitochondrial matrix / protein domain specific binding / translation / ribonucleoprotein complex / nucleotide binding / mRNA binding / apoptotic process / positive regulation of DNA-templated transcription / nucleolus / mitochondrion / RNA binding / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm

Domain/homology:

: / : / Ribosomal protein L55, mitochondrial / Mitochondrial ribosomal protein L55 superfamily / Mitochondrial ribosomal protein L55 / Mitochondrial ribosomal protein L48 / 39S ribosomal protein L40, mitochondrial / Ribosomal protein S30, mitochondrial / Ribosomal protein L53, mitochondrial / 39S ribosomal protein L53/MRP-L53 / 39S ribosomal protein L42, mitochondrial / Mitochondrial 28S ribosomal protein S32 / Ribosomal protein L37, mitochondrial / Ribosomal protein L28/L40, mitochondrial / Mitochondrial ribosomal protein L37 / Mitochondrial ribosomal protein L28 / Ribosomal protein 63, mitochondrial / Growth arrest/ DNA-damage-inducible protein-interacting protein 1 / Ribosomal protein L51, mitochondrial / Growth arrest and DNA-damage-inducible proteins-interacting protein 1 / Mitochondrial ribosomal subunit / Mitochondrial ribosome protein 63 / Ribosomal protein L37/S30 / Growth arrest and DNA damage-inducible proteins-interacting protein 1 domain superfamily / : / : / Mitochondrial 28S ribosomal protein S30 (PDCD9) / Ribosomal protein L35, mitochondrial / 39S ribosomal protein L52, mitochondrial / Mitoribosomal protein mL52 / : / MRPL44, double-stranded RNA binding domain / : / MRPL44 dsRNA-binding domain / Large ribosomal subunit protein mL44, endonuclease domain / : / Large ribosomal subunit protein bL9m C-terminal domain / Tim44-like domain / Tim44-like domain / Tim44 / Ribosomal protein L7/L12, oligomerisation / Ribosomal protein L7/L12, oligomerisation domain superfamily / Ribosomal protein L7/L12 dimerisation domain / Mitochondrial ribosomal protein L46 NUDIX / Ribosomal protein L7/L12 / Ribosomal protein L7/L12, C-terminal / : / Ribosomal protein L7/L12 C-terminal domain / : / Ribosomal protein L46, N-terminal / 39S mitochondrial ribosomal protein L46 / Ribosomal protein L50, mitochondria / Ribosomal subunit 39S / Ribosomal protein L49/IMG2 / Mitochondrial large subunit ribosomal protein (Img2) / Ribosomal protein L27/L41, mitochondrial / : / Mitochondrial ribosomal protein L27 / 39S ribosomal protein L46, mitochondrial / 39S ribosomal protein L43/54S ribosomal protein L51 / Ribosomal protein L47, mitochondrial / MRP-L47 superfamily, mitochondrial / Mitochondrial 39-S ribosomal protein L47 (MRP-L47) / Phosphatidylethanolamine-binding protein, eukaryotic / Phosphatidylethanolamine-binding protein / Phosphatidylethanolamine-binding protein / PEBP-like superfamily / Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like / Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily / TGS-like / TGS domain profile. / TGS / Peptide chain release factor class I / RF-1 domain / Ribonuclease III, endonuclease domain superfamily / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / : / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Ribosomal protein/NADH dehydrogenase domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Beta-grasp domain superfamily / NTF2-like domain superfamily / NUDIX hydrolase-like domain superfamily / Ribosomal protein L11, bacterial-type / Ribosomal protein L10-like domain superfamily / Ribosomal protein L10P / Ribosomal protein L10 / Ribosomal protein L11, N-terminal / Ribosomal protein L11, N-terminal domain / Ribosomal protein L11/L12 / Ribosomal protein L11, C-terminal / Ribosomal protein L11, C-terminal domain superfamily / Ribosomal protein L11/L12, N-terminal domain superfamily / Ribosomal protein L11/L12 / Ribosomal protein L11, RNA binding domain / Ribosomal protein L28/L24 superfamily / Ribosomal protein L9, N-terminal domain superfamily / Ribosomal protein L9 / Ribosomal protein L9, N-terminal

Component:

Large ribosomal subunit protein mL52 / Mitochondrial ribosomal protein L18, isoform CRA_b / Large ribosomal subunit protein uL22m / Large ribosomal subunit protein bL33m / Large ribosomal subunit protein uL3m / Large ribosomal subunit protein bL19m / Large ribosomal subunit protein bL12m / Large ribosomal subunit protein bL28m / Large ribosomal subunit protein mL49 / Large ribosomal subunit protein mL62 / Large ribosomal subunit protein uL23m / Large ribosomal subunit protein mL51 / Large ribosomal subunit protein uL2m / Large ribosomal subunit protein mL54 / Large ribosomal subunit protein uL14m / Large ribosomal subunit protein bL21m / Large ribosomal subunit protein mL55 / Large ribosomal subunit protein uL10m / Large ribosomal subunit protein mL41 / Large ribosomal subunit protein mL50 / Large ribosomal subunit protein mL43 / Large ribosomal subunit protein mL64 / Large ribosomal subunit protein uL30m / Large ribosomal subunit protein uL24m / Large ribosomal subunit protein mL38 / Large ribosomal subunit protein mL53 / Large ribosomal subunit protein mL48 / Large ribosomal subunit protein bL34m / Large ribosomal subunit protein mL63 / Large ribosomal subunit protein mL45 / Large ribosomal subunit protein bL32m / Large ribosomal subunit protein bL20m / Large ribosomal subunit protein uL13m / Large ribosomal subunit protein bL9m / Large ribosomal subunit protein uL4m / Large ribosomal subunit protein mL37 / Large ribosomal subunit protein mL46 / Large ribosomal subunit protein mL44 / Large ribosomal subunit protein uL29m / Large ribosomal subunit protein mL65 / Large ribosomal subunit protein mL40 / Large ribosomal subunit protein bL17m / Large ribosomal subunit protein mL66 / Large ribosomal subunit protein uL16m / Large ribosomal subunit protein mL39 / Large ribosomal subunit protein bL35m / Large ribosomal subunit protein uL15m / Large ribosomal subunit protein bL36m / Large ribosomal subunit protein bL27m / Large ribosomal subunit protein uL11m / Large ribosomal subunit protein mL42

• Biological species: Homo sapiens (human)
• Method: single particle reconstruction / cryo EM / Resolution: 2.62 Å
• Authors: Raskar T / Bibel B / Galonic Fujimori D / Fraser J

Funding support

United States, 1 items

Organization	Grant number	Country
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)	R01 AI137270	United States

• Citation: Journal: Nucleic Acids Res / Year: 2025; Title: Context-specific inhibition of mitochondrial ribosomes by phenicol and oxazolidinone antibiotics.; Authors: Brianna Bibel / Tushar Raskar / Mary Couvillion / Muhoon Lee / Jordan I Kleinman / Nono Takeuchi-Tomita / L Stirling Churchman / James S Fraser / Danica Galonić Fujimori / ; Abstract: The antibiotics chloramphenicol (CHL) and oxazolidinones, including linezolid (LZD), are known to inhibit mitochondrial translation. This can result in serious, potentially deadly, side effects when used therapeutically. Although the mechanism by which CHL and LZD inhibit bacterial ribosomes has been elucidated in detail, their mechanism of action against mitochondrial ribosomes has yet to be explored. CHL and oxazolidinones bind to the ribosomal peptidyl transfer center (PTC) of the bacterial ribosome and prevent incorporation of incoming amino acids under specific sequence contexts, causing ribosomes to stall only at certain sequences. Through mitoribosome profiling, we show that inhibition of mitochondrial ribosomes is similarly context-specific-CHL and LZD lead to mitoribosome stalling primarily when there is an alanine, serine, or threonine in the penultimate position of the nascent peptide chain. We further validate context-specific stalling through in vitro translation assays. A high-resolution cryo-electron microscopy structure of LZD bound to the PTC of the human mitoribosome shows extensive similarity to the mode of bacterial inhibition and also suggests potential avenues for altering selectivity. Our findings could help inform the rational development of future, less mitotoxic, antibiotics, which are critically needed in the current era of increasing antimicrobial resistance.

History

Deposition	Jul 15, 2024	-
Header (metadata) release	Apr 23, 2025	-
Map release	Apr 23, 2025	-
Update	May 21, 2025	-
Current status	May 21, 2025	Processing site: RCSB / Status: Released

Map

• File: Download / File: emd_45757.map.gz / Format: CCP4 / Size: 669.9 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 0.865 Å

Density

Contour Level	By AUTHOR: 0.38
Minimum - Maximum	-2.7423143 - 4.6609435
Average (Standard dev.)	-0.0014504554 (±0.09570489)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 560 560 560 Spacing 560 560 560
Cell	A=B=C: 484.4 Å α=β=γ: 90.0 °

Supplemental data

Half map: #2

• File: emd_45757_half_map_1.map

Half map: #1

• File: emd_45757_half_map_2.map

Sample components

Entire : 39S subunit of human mitochondrial ribosome in complex with Linezolid

• Entire: Name: 39S subunit of human mitochondrial ribosome in complex with Linezolid

Components

• Complex: 39S subunit of human mitochondrial ribosome in complex with Linezolid
  • Protein or peptide: 39S ribosomal protein L32, mitochondrial
  • Protein or peptide: 39S ribosomal protein L33, mitochondrial
  • Protein or peptide: 39S ribosomal protein L34, mitochondrial
  • Protein or peptide: 39S ribosomal protein L35, mitochondrial
  • Protein or peptide: 39S ribosomal protein L36, mitochondrial
  • Protein or peptide: 39S ribosomal protein L37, mitochondrial
  • Protein or peptide: 39S ribosomal protein L38, mitochondrial
  • Protein or peptide: 39S ribosomal protein L39, mitochondrial
  • Protein or peptide: 39S ribosomal protein L40, mitochondrial
  • Protein or peptide: 39S ribosomal protein L41, mitochondrial
  • RNA: 16S rRNA
  • RNA: tRNA
  • Protein or peptide: 39S ribosomal protein L2, mitochondrial
  • Protein or peptide: 39S ribosomal protein L3, mitochondrial
  • Protein or peptide: 39S ribosomal protein L4, mitochondrial
  • Protein or peptide: 39S ribosomal protein L9, mitochondrial
  • Protein or peptide: 39S ribosomal protein L10, mitochondrial
  • Protein or peptide: 39S ribosomal protein L11, mitochondrial
  • Protein or peptide: 39S ribosomal protein L13, mitochondrial
  • Protein or peptide: 39S ribosomal protein L14, mitochondrial
  • Protein or peptide: 39S ribosomal protein L15, mitochondrial
  • Protein or peptide: 39S ribosomal protein L16, mitochondrial
  • Protein or peptide: 39S ribosomal protein L17, mitochondrial
  • Protein or peptide: Mitochondrial ribosomal protein L18, isoform CRA_b
  • Protein or peptide: 39S ribosomal protein L19, mitochondrial
  • Protein or peptide: 39S ribosomal protein L20, mitochondrial
  • Protein or peptide: 39S ribosomal protein L21, mitochondrial
  • Protein or peptide: 39S ribosomal protein L22, mitochondrial
  • Protein or peptide: 39S ribosomal protein L23, mitochondrial
  • Protein or peptide: 39S ribosomal protein L24, mitochondrial
  • Protein or peptide: 39S ribosomal protein L27, mitochondrial
  • Protein or peptide: 39S ribosomal protein L28, mitochondrial
  • Protein or peptide: 39S ribosomal protein L47, mitochondrial
  • Protein or peptide: 39S ribosomal protein L30, mitochondrial
  • Protein or peptide: 39S ribosomal protein L42, mitochondrial
  • Protein or peptide: 39S ribosomal protein L43, mitochondrial
  • Protein or peptide: 39S ribosomal protein L44, mitochondrial
  • Protein or peptide: 39S ribosomal protein L45, mitochondrial
  • Protein or peptide: 39S ribosomal protein L46, mitochondrial
  • Protein or peptide: 39S ribosomal protein L48, mitochondrial
  • Protein or peptide: 39S ribosomal protein L49, mitochondrial
  • Protein or peptide: 39S ribosomal protein L50, mitochondrial
  • Protein or peptide: 39S ribosomal protein L51, mitochondrial
  • Protein or peptide: cDNA FLJ76418, highly similar to Homo sapiens mitochondrial ribosomal protein L52 (MRPL52), transcript variant 1, mRNA
  • Protein or peptide: 39S ribosomal protein L53, mitochondrial
  • Protein or peptide: 39S ribosomal protein L54, mitochondrial
  • Protein or peptide: 39S ribosomal protein L55, mitochondrial
  • Protein or peptide: Ribosomal protein 63, mitochondrial
  • Protein or peptide: Peptidyl-tRNA hydrolase ICT1, mitochondrial
  • Protein or peptide: Growth arrest and DNA damage-inducible proteins-interacting protein 1
  • Protein or peptide: 39S ribosomal protein S18a, mitochondrial
  • Protein or peptide: 39S ribosomal protein S30, mitochondrial
  • Protein or peptide: P-site finger
  • Protein or peptide: 39S ribosomal protein L12, mitochondrial
• Ligand: ZINC ION
• Ligand: MAGNESIUM ION
• Ligand: N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
• Ligand: water

Supramolecule #1: 39S subunit of human mitochondrial ribosome in complex with Linezolid

• Supramolecule: Name: 39S subunit of human mitochondrial ribosome in complex with Linezolid; type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#54 / Details: Purified from freestyle 293 cells
• Source (natural): Organism: Homo sapiens (human)

Macromolecule #1: 39S ribosomal protein L32, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L32, mitochondrial / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.437799 KDa

Sequence

String:

MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ GPAMFTEPAN DTSGSKENSS LLDSIFWMAA PKNRRTIEV NRCRRRNPQK LIKVKNNIDV CPECGHLKQK HVLCAYCYEK VCKETAEIRR QIGKQEGGPF KAPTIETVVL Y TGETPSEQ DQGKRIIERD RKRPSWFTQN

UniProtKB: Large ribosomal subunit protein bL32m

Macromolecule #2: 39S ribosomal protein L33, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L33, mitochondrial / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 7.635204 KDa

Sequence

String:

MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK KIRSL

UniProtKB: Large ribosomal subunit protein bL33m

Macromolecule #3: 39S ribosomal protein L34, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L34, mitochondrial / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 10.183913 KDa

Sequence

String:

MAVLAGSLLG PTSRSAALLG GRWLQPRAWL GFPDAWGLPT PQQARGKARG NEYQPSNIKR KNKHGWVRRL STPAGVQVIL RRMLKGRKS LSH

UniProtKB: Large ribosomal subunit protein bL34m

Macromolecule #4: 39S ribosomal protein L35, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L35, mitochondrial / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.558488 KDa

Sequence

String:

MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL TTSERNLTCG HTSVILNRMA PVLPSVLKL PVRSLTYFSA RKGKRKTVKA VIDRFLRLHC GLWVRRKAGY KKKLWKKTPA RKKRLREFVF CNKTQSKLLD K MTTSFWKR RNWYVDDPYQ KYHDRTNLKV

UniProtKB: Large ribosomal subunit protein bL35m

Macromolecule #5: 39S ribosomal protein L36, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L36, mitochondrial / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 11.809301 KDa

Sequence

String:

MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWY VYCKTHPRHK QRQM

UniProtKB: Large ribosomal subunit protein bL36m

Macromolecule #6: 39S ribosomal protein L37, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L37, mitochondrial / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 48.183344 KDa

Sequence

String:

MALASGPARR ALAGSGQLGL GGFGAPRRGA YEWGVRSTRK SEPPPLDRVY EIPGLEPITF AGKMHFVPWL ARPIFPPWDR GYKDPRFYR SPPLHEHPLY KDQACYIFHH RCRLLEGVKQ ALWLTKTKLI EGLPEKVLSL VDDPRNHIEN QDECVLNVIS H ARLWQTTE EIPKRETYCP VIVDNLIQLC KSQILKHPSL ARRICVQNST FSATWNRESL LLQVRGSGGA RLSTKDPLPT IA SREEIEA TKNHVLETFY PISPIIDLHE CNIYDVKNDT GFQEGYPYPY PHTLYLLDKA NLRPHRLQPD QLRAKMILFA FGS ALAQAR LLYGNDAKVL EQPVVVQSVG TDGRVFHFLV FQLNTTDLDC NEGVKNLAWV DSDQLLYQHF WCLPVIKKRV VVEP VGPVG FKPETFRKFL ALYLHGAA

UniProtKB: Large ribosomal subunit protein mL37

Macromolecule #7: 39S ribosomal protein L38, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L38, mitochondrial / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 44.65943 KDa

Sequence

String:

MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR AEQEAQAPHW WRTYREYFGE KTDPKEKID IGLPPPKVSR TQQLLERKQA IQELRANVEE ERAARLRTAS VPLDAVRAEW ERTCGPYHKQ RLAEYYGLYR D LFHGATFV PRVPLHVAYA VGEDDLMPVY CGNEVTPTEA AQAPEVTYEA EEGSLWTLLL TSLDGHLLEP DAEYLHWLLT NI PGNRVAE GQVTCPYLPP FPARGSGIHR LAFLLFKQDQ PIDFSEDARP SPCYQLAQRT FRTFDFYKKH QETMTPAGLS FFQ CRWDDS VTYIFHQLLD MREPVFEFVR PPPYHPKQKR FPHRQPLRYL DRYRDSHEPT YGIY

UniProtKB: Large ribosomal subunit protein mL38

Macromolecule #8: 39S ribosomal protein L39, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L39, mitochondrial / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.764785 KDa

Sequence

String:

MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPY SCAMHLSEWY CRKSILALVD GQPWDMYKPL TKSCEIKFLT FKDCDPGEVN KAYWRSCAMM MGCVIERAFK D EYMVNLVR APEVPVISGA FCYDVVLDSK LDEWMPTKEN LRSFTKDAHA LIYKDLPFET LEVEAKVALE IFQHSKYKVD FI EEKASQN PERIVKLHRI GDFIDVSEGP LIPRTSICFQ YEVSAVHNLQ PTQPSLIRRF QGVSLPVHLR AHFTIWDKLL ERS RKMVTE DQSKATEECT ST

UniProtKB: Large ribosomal subunit protein mL39

Macromolecule #9: 39S ribosomal protein L40, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L40, mitochondrial / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.534422 KDa

Sequence

String:

MTASVLRSIS LALRPTSGLL GTWQTQLRET HQRASLLSFW ELIPMRSEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFI TPLKFLDKAR ERPQVELTFE ETERRALLLK KWSLYKQQER KMERDTIRAM LEAQQEALEE LQLESPKLHA E AIKRDPNL FPFEKEGPHY TPPIPNYQPP EGRYNDITKV YTQVEFKR

UniProtKB: Large ribosomal subunit protein mL40

Macromolecule #10: 39S ribosomal protein L41, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L41, mitochondrial / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.404708 KDa

Sequence

String:

MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAA QLFSEAVAPA IEKDFKDGTF DPDNLEKYGF EPTQEGKLFQ LYPRNFLR

UniProtKB: Large ribosomal subunit protein mL41

Macromolecule #13: 39S ribosomal protein L2, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L2, mitochondrial / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.355941 KDa

Sequence

String:

MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTG RIRVHGIGGG HKQRYRMIDF LRFRPEETKS GPFEEKVIQV RYDPCRSADI ALVAGGSRKR WIIATENMQA G DTILNSNH IGRMAVAARE GDAHPLGALP VGTLINNVES EPGRGAQYIR AAGTCGVLLR KVNGTAIIQL PSKRQMQVLE TC VATVGRV SNVDHNKRVI GKAGRNRWLG KRPNSGRWHR KGGWAGRKIR PLPPMKSYVK LPSASAQS

UniProtKB: Large ribosomal subunit protein uL2m

Macromolecule #14: 39S ribosomal protein L3, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L3, mitochondrial / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 38.689562 KDa

Sequence

String:

MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT S ILEFYREL GLPPKQTVKI FNITDNAAIK PGTPLYAAHF RPGQYVDVTA KTIGKGFQGV MKRWGFKGQP ATHGQTKTHR RP GAVATGD IGRVWPGTKM PGKMGNIYRT EYGLKVWRIN TKHNIIYVNG SVPGHKNCLV KVKDSKLPAY KDLGKNLPFP TYF PDGDEE ELPEDLYDEN VCQPGAPSIT FA

UniProtKB: Large ribosomal subunit protein uL3m

Macromolecule #15: 39S ribosomal protein L4, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L4, mitochondrial / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 34.970195 KDa

Sequence

String:

MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR PVQAWVESLR GFEQERVGLA DLHPDVFAT APRLDILHQV AMWQKNFKRI SYAKTKTRAE VRGGGRKPWP QKGTGRARHG SIRSPLWRGG GVAHGPRGPT S YYYMLPMK VRALGLKVAL TVKLAQDDLH IMDSLELPTG DPQYLTELAH YRRWGDSVLL VDLTHEEMPQ SIVEATSRLK TF NLIPAVG LNVHSMLKHQ TLVLTLPTVA FLEDKLLWQD SRYRPLYPFS LPYSDFPRPL PHATQGPAAT PYHC

UniProtKB: Large ribosomal subunit protein uL4m

Macromolecule #16: 39S ribosomal protein L9, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L9, mitochondrial / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.296355 KDa

Sequence

String:

MAAPVVTAPG RALLRAGAGR LLRGGVQELL RPRHEGNAPD LACNFSLSQN RGTVIVERWW KVPLAGEGRK PRLHRRHRVY KLVEDTKHR PKENLELILT QSVENVGVRG DLVSVKKSLG RNRLLPQGLA VYASPENKKL FEEEKLLRQE GKLEKIQTKA G EATVKFLK SCRLEVGMKN NVKWELNPEI VARHFFKNLG VVVAPHTLKL PEEPITRWGE YWCEVTVNGL DTVRVPMSVV NF EKPKTKR YKYWLAQQAA KAMAPTSPQI

UniProtKB: Large ribosomal subunit protein bL9m

Macromolecule #17: 39S ribosomal protein L10, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L10, mitochondrial / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.322529 KDa

Sequence

String:

MAAAVAGMLR GGLLPQAGRL PTLQTVRYGS KAVTRHRRVM HFQRQKLMAV TEYIPPKPAI HPSCLPSPPS PPQEEIGLIR LLRREIAAV FQDNRMIAVC QNVALSAEDK LLMRHQLRKH KILMKVFPNQ VLKPFLEDSK YQNLLPLFVG HNMLLVSEEP K VKEMVRIL RTVPFLPLLG GCIDDTILSR QGFINYSKLP SLPLVQGELV GGLTCLTAQT HSLLQHQPLQ LTTLLDQYIR EQ REKDSVM SANGKPDPDT VPDS

UniProtKB: Large ribosomal subunit protein uL10m

Macromolecule #18: 39S ribosomal protein L11, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L11, mitochondrial / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.716227 KDa

Sequence

String:

MSKLGRAARG LRKPEVGGVI RAIVRAGLAM PGPPLGPVLG QRGVSINQFC KEFNERTKDI KEGIPLPTKI LVKPDRTFEI KIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL S SEELAAFQ KERAIFLAAQ KEADLAAQEE AAKK

UniProtKB: Large ribosomal subunit protein uL11m

Macromolecule #19: 39S ribosomal protein L13, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L13, mitochondrial / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.722988 KDa

Sequence

String:

MSSFSRAPQQ WATFARIWYL LDGKMQPPGK LAAMASIRLQ GLHKPVYHAL SDCGDHVVIM NTRHIAFSGN KWEQKVYSSH TGYPGGFRQ VTAAQLHLRD PVAIVKLAIY GMLPKNLHRR TMMERLHLFP DEYIPEDILK NLVEELPQPR KIPKRLDEYT Q EEIDAFPR LWTPPEDYRL

UniProtKB: Large ribosomal subunit protein uL13m

Macromolecule #20: 39S ribosomal protein L14, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L14, mitochondrial / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.973702 KDa

Sequence

String:

MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGH CMPGPRMTPR FDSNNVVLIE DNGNPVGTRI KTPIPTSLRK REGEYSKVLA IAQNFV

UniProtKB: Large ribosomal subunit protein uL14m

Macromolecule #21: 39S ribosomal protein L15, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L15, mitochondrial / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.47382 KDa

Sequence

String:

MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSF RRQYKPLSLN RLQYLIDLGR VDPSQPIDLT QLVNGRGVTI QPLKRDYGVQ LVEEGADTFT AKVNIEVQLA S ELAIAAIE KNGGVVTTAF YDPRSLDIVC KPVPFFLRGQ PIPKRMLPPE ELVPYYTDAK NRGYLADPAK FPEARLELAR KY GYILPDI TKDELFKMLC TRKDPRQIFF GLAPGWVVNM ADKKILKPTD ENLLKYYTS

UniProtKB: Large ribosomal subunit protein uL15m

Macromolecule #22: 39S ribosomal protein L16, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L16, mitochondrial / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 28.496285 KDa

Sequence

String:

MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAI LALGGGYLHW GHFEMMRLTI NRSMDPKNMF AIWRVPAPFK PITRKSVGHR MGGGKGAIDH YVTPVKAGRL V VEMGGRCE FEEVQGFLDQ VAHKLPFAAK AVSRGTLEKM RKDQEERERN NQNPWTFERI ATANMLGIRK VLSPYDLTHK GK YWGKFYM PKRV

UniProtKB: Large ribosomal subunit protein uL16m

Macromolecule #23: 39S ribosomal protein L17, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L17, mitochondrial / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.083266 KDa

Sequence

String:

MRLSVAAAIS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKL FQVLAPRYKD QTGGYTRMLQ IPNRSLDRAK MAVIEYKGNC LPPLPLPRRD SHLTLLNQLL QGLRQDLRQS Q EASNHSSH TAQTPGI

UniProtKB: Large ribosomal subunit protein bL17m

Macromolecule #24: Mitochondrial ribosomal protein L18, isoform CRA_b

• Macromolecule: Name: Mitochondrial ribosomal protein L18, isoform CRA_b / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 20.465348 KDa

Sequence

String:

MALRSQFWGF SVCRNPGCRF AALSTSSEPA AKPEVDPVEN EAVAPEFTNR NPRNLELLSV ARKERGWRTV FPSREFWHRL RVIRTQHHV EALVEHQNGK VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP WEAASDSMKR L QSAMTEGG VVLREPQRIY E

UniProtKB: Mitochondrial ribosomal protein L18, isoform CRA_b

Macromolecule #25: 39S ribosomal protein L19, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L19, mitochondrial / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 33.584996 KDa

Sequence

String:

MAACIAAGHW AAMGLGRSFQ AARTLLPPPA SIACRVHAGP VRQQSTGPSE PGAFQPPPKP VIVDKHRPVE PERRFLSPEF IPRRGRTDP LKFQIERKDM LERRKVLHIP EFYVGSILRV TTADPYASGK ISQFLGICIQ RSGRGLGATF ILRNVIEGQG V EICFELYN PRVQEIQVVK LEKRLDDSLL YLRDALPEYS TFDVNMKPVV QEPNQKVPVN ELKVKMKPKP WSKRWERPNF NI KGIRFDL CLTEQQMKEA QKWNQPWLEF DMMREYDTSK IEAAIWKEIE ASKRS

UniProtKB: Large ribosomal subunit protein bL19m

Macromolecule #26: 39S ribosomal protein L20, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L20, mitochondrial / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.479654 KDa

Sequence

String:

MVFLTAQLWL RNRVTDRYFR IQEVLKHARH FRGRKNRCYR LAVRTVIRAF VKCTKARYLK KKNMRTLWIN RITAASQEHG LKYPALIGN LVKCQVELNR KVLADLAIYE PKTFKSLAAL ASRRRHEGFA AALGDGKEPE GIFSRVVQYH

UniProtKB: Large ribosomal subunit protein bL20m

Macromolecule #27: 39S ribosomal protein L21, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L21, mitochondrial / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.847682 KDa

Sequence

String:

MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVT GQYGRLFAVV HFASRQWKVT SEDLILIGNE LDLACGERIR LEKVLLVGAD NFTLLGKPLL GKDLVRVEAT V IEKTESWP RIIMRFRKRK NFKKKRIVTT PQTVLRINSI EIAPCLL

UniProtKB: Large ribosomal subunit protein bL21m

Macromolecule #28: 39S ribosomal protein L22, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L22, mitochondrial / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.369527 KDa

Sequence

String:

MAAAVLGQLG ALWIHNLRSR GKLALGLLSF HSVLPQSYIH TSASLDISRK WEKKNKIVYP PQLPGEPRRP AEIYHCRRQI KYSKDKMWY LAKLIRGMSI DQALAQLEFN DKKGAKIIKE VLLEAQDMAV RDHNVEFRSN LYIAESTSGR GQCLKRIRYH G RGRFGIME KVYCHYFVKL VEGPPPPPEP PKTAVAHAKE YIQQLRSRTI VHTL

UniProtKB: Large ribosomal subunit protein uL22m

Macromolecule #29: 39S ribosomal protein L23, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L23, mitochondrial / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.807189 KDa

Sequence

String:

MARNVVYPLY RLGGPQLRVF RTNFFIQLVR PGVAQPEDTV QFRIPMEMTR VDLRNYLEGI YNVPVAAVRT RVQHGSNKRR DHRNVRIKK PDYKVAYVQL AHGQTFTFPD LFPEKDESPE GSAADDLYSM LEEERQQRQS SDPRRGGVPS WFGL

UniProtKB: Large ribosomal subunit protein uL23m

Macromolecule #30: 39S ribosomal protein L24, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L24, mitochondrial / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 24.953875 KDa

Sequence

String:

MRLSALLALA SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVG GLNTHYRYIG KTMDYRGTMI PSEAPLLHRQ VKLVDPMDRK PTEIEWRFTE AGERVRVSTR SGRIIPKPEF P RADGIVPE TWIDGPKDTS VEDALERTYV PCLKTLQEEV MEAMGIKETR KYKKVYWY

UniProtKB: Large ribosomal subunit protein uL24m

Macromolecule #31: 39S ribosomal protein L27, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L27, mitochondrial / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.102859 KDa

Sequence

String:

MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCL YALEEGIVRY TKEVYVPHPR NTEAVDLITR LPKGAVLYKT FVHVVPAKPE GTFKLVAML

UniProtKB: Large ribosomal subunit protein bL27m

Macromolecule #32: 39S ribosomal protein L28, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L28, mitochondrial / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 30.202867 KDa

Sequence

String:

MPLHKYPVWL WKRLQLREGI CSRLPGHYLR SLEEERTPTP VHYRPHGAKF KINPKNGQRE RVEDVPIPIY FPPESQRGLW GGEGWILGQ IYANNDKLSK RLKKVWKPQL FEREFYSEIL DKKFTVTVTM RTLDLIDEAY GLDFYILKTP KEDLCSKFGM D LKRGMLLR LARQDPQLHP EDPERRAAIY DKYKEFAIPE EEAEWVGLTL EEAIEKQRLL EEKDPVPLFK IYVAELIQQL QQ QALSEPA VVQKRASGQ

UniProtKB: Large ribosomal subunit protein bL28m

Macromolecule #33: 39S ribosomal protein L47, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L47, mitochondrial / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 29.508535 KDa

Sequence

String:

MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQ LRNKSNEDLH KLWYVLLKER NMLLTLEQEA KRQRLPMPSP ERLDKVVDSM DALDKVVQER EDALRLLQTG Q ERARPGAW RRDIFGRIIW HKFKQWVIPW HLNKRYNRKR FFALPYVDHF LRLEREKRAR IKARKENLER KKAKILLKKF PH LAEAQKS SLV

UniProtKB: Large ribosomal subunit protein uL29m

Macromolecule #34: 39S ribosomal protein L30, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L30, mitochondrial / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.582812 KDa

Sequence

String:

MAGILRLVVQ WPPGRLQTVT KGVESLICTD WIRHKFTRSR IPEKVFQASP EDHEKYGGDP QNPHKLHIVT RIKSTRRRPY WEKDIIKML GLEKAHTPQV HKNIPSVNAK LKVVKHLIRI KPLKLPQGLP AEENMSNTCL KSTGELVVQW HLKPVEQKAH E S

UniProtKB: Large ribosomal subunit protein uL30m

Macromolecule #35: 39S ribosomal protein L42, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L42, mitochondrial / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 16.691176 KDa

Sequence

String:

MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHD QVLKTRLEEK VEHLEEGPMI EQLSKMFFTT KHRWYPHGRY HRCRKNLNPP KDR

UniProtKB: Large ribosomal subunit protein mL42

Macromolecule #36: 39S ribosomal protein L43, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L43, mitochondrial / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 17.452789 KDa

Sequence

String:

MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG VVIYVNSRPC CVPRVVAEYL NGAVREESI HCKSVEEIST LVQKLADQSG LDVIRIRKPF HTDNPSIQGQ WHPFTNKPTT FRGLRPREVQ DPAPAQ

UniProtKB: Large ribosomal subunit protein mL43

Macromolecule #37: 39S ribosomal protein L44, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L44, mitochondrial / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO; EC number: Hydrolases; Acting on ester bonds; Endoribonucleases producing 5'-phosphomonoesters
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 37.583312 KDa

Sequence

String:

MASGLVRLLQ QGHRCLLAPV APKLVPPVRG VKKGFRAAFR FQKELERQRL LRCPPPPVRR SEKPNWDYHA EIQAFGHRLQ ENFSLDLLK TAFVNSCYIK SEEAKRQQLG IEKEAVLLNL KSNQELSEQG TSFSQTCLTQ FLEDEYPDMP TEGIKNLVDF L TGEEVVCH VARNLAVEQL TLSEEFPVPP AVLQQTFFAV IGALLQSSGP ERTALFIRDF LITQMTGKEL FEMWKIINPM GL LVEELKK RNVSAPESRL TRQSGGTTAL PLYFVGLYCD KKLIAEGPGE TVLVAEEEAA RVALRKLYGF TENRRPWNYS KPK ETLRAE KSITAS

UniProtKB: Large ribosomal subunit protein mL44

Macromolecule #38: 39S ribosomal protein L45, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L45, mitochondrial / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 35.402918 KDa

Sequence

String:

MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYV PPEGDARISS LSKEGLIERT ERMKKTMASQ VSIRRIKDYD ANFKIKDFPE KAKDIFIEAH LCLNNSDHDR L HTLVTEHC FPDMTWDIKY KTVRWSFVES LEPSHVVQVR CSSMMNQGNV YGQITVRMHT RQTLAIYDRF GRLMYGQEDV PK DVLEYVV FEKQLTNPYG SWRMHTKIVP PWAPPKQPIL KTVMIPGPQL KPEEEYEEAQ GEAQKPQLA

UniProtKB: Large ribosomal subunit protein mL45

Macromolecule #39: 39S ribosomal protein L46, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L46, mitochondrial / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 31.748107 KDa

Sequence

String:

MAAPVRRTLL GVAGGWRRFE RLWAGSLSSR SLALAAAPSS NGSPWRLLGA LCLQRPPVVS KPLTPLQEEM ASLLQQIEIE RSLYSDHEL RALDENQRLA KKKADLHDEE DEQDILLAQD LEDMWEQKFL QFKLGARITE ADEKNDRTSL NRKLDRNLVL L VREKFGDQ DVWILPQAEW QPGETLRGTA ERTLATLSEN NMEAKFLGNA PCGHYTFKFP QAMRTESNLG AKVFFFKALL LT GDFSQAG NKGHHVWVTK DELGDYLKPK YLAQVRRFVS DL

UniProtKB: Large ribosomal subunit protein mL46

Macromolecule #40: 39S ribosomal protein L48, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L48, mitochondrial / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.856232 KDa

Sequence

String:

MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK HLIKAEEPKK KKGKVEVRAI NLGTDYEYG VLNIHLTAYD MTLAESYAQY VHNLCNSLSI KVEESYAMPT KTIEVLQLQD QGSKMLLDSV LTTHERVVQI S GLSATFAE IFLEIIQSSL PEGVRLSVKE HTEEDF

UniProtKB: Large ribosomal subunit protein mL48

Macromolecule #41: 39S ribosomal protein L49, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L49, mitochondrial / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 19.225043 KDa

Sequence

String:

MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP PKHEHYPTPS GWQPPRDPPP NLPYFVRRS RMHNIPVYKD ITHGNRQMTV IRKVEGDIWA LQKDVEDFLS PLLGKTPVTQ VNEVTGTLRI KGYFDQELKA W LLEKGF

UniProtKB: Large ribosomal subunit protein mL49

Macromolecule #42: 39S ribosomal protein L50, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L50, mitochondrial / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 18.349943 KDa

Sequence

String:

MAARSVSGIT RRVFMWTVSG TPCREFWSRF RKEKEPVVVE TVEEKKEPIL VCPPLRSRAY TPPEDLQSRL ESYVKEVFGS SLPSNWQDI SLEDSRLKFN LLAHLADDLG HVVPNSRLHQ MCRVRDVLDF YNVPIQDRSK FDELSASNLP PNLKITWSY

UniProtKB: Large ribosomal subunit protein mL50

Macromolecule #43: 39S ribosomal protein L51, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L51, mitochondrial / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.125917 KDa

Sequence

String:

MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQ RCIRKRKMVG SRMFADDLHN LNKRIRYLYK HFNRHGKFR

UniProtKB: Large ribosomal subunit protein mL51

Macromolecule #44: cDNA FLJ76418, highly similar to Homo sapiens mitochondrial ribos...

• Macromolecule: Name: cDNA FLJ76418, highly similar to Homo sapiens mitochondrial ribosomal protein L52 (MRPL52), transcript variant 1, mRNA; type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 13.696684 KDa

Sequence

String:

MAALVTVLFT GVRRLHCSAA AWAGGQWRLQ QGLAANPSGY GPLTELPDWS YADGRPAPPM KGQLRRKAER ETFARRVVLL SQEMDAGLQ AWQLRQQKLQ EEQRKQENAL KPKGASLKSP LPSQ

UniProtKB: Large ribosomal subunit protein mL52

Macromolecule #45: 39S ribosomal protein L53, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L53, mitochondrial / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.125859 KDa

Sequence

String:

MAAALARLGL RPVKQVRVQF CPFEKNVEST RTFLQTVSSE KVRSTNLNCS VIADVRHDGS EPCVDVLFGD GHRLIMRGAH LTALEMLTA FASHIRARDA AGSGDKPGAD TGR

UniProtKB: Large ribosomal subunit protein mL53

Macromolecule #46: 39S ribosomal protein L54, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L54, mitochondrial / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.844178 KDa

Sequence

String:

MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPD AEYPEWLFEM NLGPPKTLEE LDPESREYWR RLRKQNIWRH NRLSKNKRL

UniProtKB: Large ribosomal subunit protein mL54

Macromolecule #47: 39S ribosomal protein L55, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L55, mitochondrial / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 15.160433 KDa

Sequence

String:

MAAVGSLLGR LRQSTVKATG PALRRLHTSS WRADSSRASL TRVHRQAYAR LYPVLLVKQD GSTIHIRYRE PRRMLAMPID LDTLSPEER RARLRKREAQ LQSRKEYEQE LSDDLHVERY RQFWTRTKK

UniProtKB: Large ribosomal subunit protein mL55

Macromolecule #48: Ribosomal protein 63, mitochondrial

• Macromolecule: Name: Ribosomal protein 63, mitochondrial / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 12.292333 KDa

Sequence

String:

MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIA DQLDHLNVTK KWS

UniProtKB: Large ribosomal subunit protein mL63

Macromolecule #49: Peptidyl-tRNA hydrolase ICT1, mitochondrial

• Macromolecule: Name: Peptidyl-tRNA hydrolase ICT1, mitochondrial / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidyl-tRNA hydrolase
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 23.674203 KDa

Sequence

String:

MAATRCLRWG LSRAGVWLLP PPARCPRRAL HKQKDGTEFK SIYSLDKLYP ESQGSDTAWR VPNGAKQADS DIPLDRLTIS YCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT E ASQTPKEP TKEDVKLHRI RIENMNRERL RQKRIHSAVK TSRRVDMD

UniProtKB: Large ribosomal subunit protein mL62

Macromolecule #50: Growth arrest and DNA damage-inducible proteins-interacting protein 1

• Macromolecule: Name: Growth arrest and DNA damage-inducible proteins-interacting protein 1; type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 25.426895 KDa

Sequence

String:

MAASVRQARS LLGVAATLAP GSRGYRARPP PRRRPGPRWP DPEDLLTPRW QLGPRYAAKQ FARYGAASGV VPGSLWPSPE QLRELEAEE REWYPSLATM QESLRVKQLA EEQKRREREQ HIAECMAKMP QMIVNWQQQQ RENWEKAQAD KERRARLQAE A QELLGYQV DPRSARFQEL LQDLEKKERK RLKEEKQKRK KEARAAALAA AVAQDPAASG APSS

UniProtKB: Large ribosomal subunit protein mL64

Macromolecule #51: 39S ribosomal protein S18a, mitochondrial

• Macromolecule: Name: 39S ribosomal protein S18a, mitochondrial / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.224078 KDa

Sequence

String:

MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES PNPPNPSGQC PICRWNLKHK YNYDDVLLL SQFIRPHGGM LPRKITGLCQ EEHRKIEECV KMAHRAGLLP NHRPRLPEGV VPKSKPQLNR YLTRWAPGSV K PIYKKGPR WNRVRMPVGS PLLRDNVCYS RTPWKLYH

UniProtKB: Large ribosomal subunit protein mL66

Macromolecule #52: 39S ribosomal protein S30, mitochondrial

• Macromolecule: Name: 39S ribosomal protein S30, mitochondrial / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 50.429578 KDa

Sequence

String:

MAAARCWRPL LRGPRLSLHT AANAAATATE TTCQDVAATP VARYPPIVAS MTADSKAARL RRIERWQATV HAAESVDEKL RILTKMQFM KYMVYPQTFA LNADRWYQYF TKTVFLSGLP PPPAEPEPEP EPEPEPALDL AALRAVACDC LLQEHFYLRR R RRVHRYEE SEVISLPFLD QLVSTLVGLL SPHNPALAAA ALDYRCPVHF YWVRGEEIIP RGHRRGRIDD LRYQIDDKPN NQ IRISKQL AEFVPLDYSV PIEIPTIKCK PDKLPLFKRQ YENHIFVGSK TADPCCYGHT QFHLLPDKLR RERLLRQNCA DQI EVVFRA NAIASLFAWT GAQAMYQGFW SEADVTRPFV SQAVITDGKY FSFFCYQLNT LALTTQADQN NPRKNICWGT QSKP LYETI EDNDVKGFND DVLLQIVHFL LNRPKEEKSQ LLEN

UniProtKB: Large ribosomal subunit protein mL65

Macromolecule #53: P-site finger

• Macromolecule: Name: P-site finger / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 60.442441 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)

Macromolecule #54: 39S ribosomal protein L12, mitochondrial

• Macromolecule: Name: 39S ribosomal protein L12, mitochondrial / type: protein_or_peptide / ID: 54 / Number of copies: 3 / Enantiomer: LEVO
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 21.378164 KDa

Sequence

String:

MLPAAARPLW GPCLGLRAAA FRLARRQVPC VCAVRHMRSS GHQRCEALAG APLDNAPKEY PPKIQQLVQD IASLTLLEIS DLNELLKKT LKIQDVGLVP MGGVMSGAVP AAAAQEAVEE DIPIAKERTH FTVRLTEAKP VDKVKLIKEI KNYIQGINLV Q AKKLVESL PQEIKANVAK AEAEKIKAAL EAVGGTVVLE

UniProtKB: Large ribosomal subunit protein bL12m

Macromolecule #11: 16S rRNA

• Macromolecule: Name: 16S rRNA / type: rna / ID: 11 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 500.019594 KDa

Sequence

String:

GCUAAACCUA GCCCCAAACC CACUCCACCU UACUACCAGA CAACCUUAGC CAAACCAUUU ACCCAAAUAA AGUAUAGGCG AUAGAAAUU GAAACCUGGC GCAAUAGAUA UAGUACCGCA AGGGAAAGAU GAAAAAUUAU AACCAAGCAU AAUAUAGCAA G GACUAACC CCUAUACCUU CUGCAUAAUG AAUUAACUAG AAAUAACUUU GCAAGGAGAG CCAAAGCUAA GACCCCCGAA AC CAGACGA GCUACCUAAG AACAGCUAAA AGAGCACACC CGUCUAUGUA GCAAAAUAGU GGGAAGAUUU AUAGGUAGAG GCG ACAAAC CUACCGAGCC UGGUGAUAGC UGGUUGUCCA AGAUAGAAUC UUAGUUCAAC UUUAAAUUUG CCCACAGAAC CCUC UAAAU CCCCUUGUAA AUUUAACUGU UAGUCCAAAG AGGAACAGCU CUUUGGACAC UAGGAAAAAA CCUUGUAGAG AGAGU AAAA AAUUUAACAC CCAUAGUAGG CCUAAAAGCA GCCACCAAUU AAGAAAGCGU UCAAGCUCAA CACCCACUAC CUAAAA AAU CCCAAACAUA UAACUGAACU CCUCACACCC AAUUGGACCA AUCUAUCACC CUAUAGAAGA ACUAAUGUUA GUAUAAG UA ACAUGAAAAC AUUCUCCUCC GCAUAAGCCU GCGUCAGAUU AAAACACUGA ACUGACAAUU AACAGCCCAA UAUCUACA A UCAACCAACA AGUCAUUAUU ACCCUCACUG UCAACCCAAC ACAGGCAUGC UCAUAAGGAA AGGUUAAAAA AAGUAAAAG GAACUCGGCA AAUCUUACCC CGCCUGUUUA CCAAAAACAU CACCUCUAGC AUCACCAGUA UUAGAGGCAC CGCCUGCCCA GUGACACAU GUUUAACGGC CGCGGUACCC UAACCGUGCA AAGGUAGCAU AAUCACUUGU UCCUUAAAUA GGGACCUGUA U GAAUGGCU CCACGAGGGU UCAGCUGUCU CUUACUUUUA ACCAGUGAAA UUGACCUGCC CGUGAAGAGG CGGGCAUAAC AC AGCAAGA CGAGAAGACC CUAUGGAGCU UUAAUUUAUU AAUGCAAACA GUACCUAACA AACCCACAGG UCCUAAACUA CCA AACCUG CAUUAAAAAU UUCGGUUGGG GCGACCUCGG AGCAGAACCC AACCUCCGAG CAGUACAUGC UAAGACUUCA CCAG UCAAA GCGAACUACU AUACUCAAUU GAUCCAAUAA CUUGACCAAC GGAACAAGUU ACCCUAGGGA UAACAGCGCA AUCCU AUUC UAGAGUCCAU AUCAACAAUA GGGUUUACGA CCUCGAUGUU GGAUCAGGAC AUCCCGAUGG UGCAGCCGCU AUUAAA GGU UCGUUUGUUC AACGAUUAAA GUCCUACGUG AUCUGAGUUC AGACCGGAGU AAUCCAGGUC GGUUUCUAUC UACUUUC AA AUUCCUCCCU GUACGAAAGG ACAAGAGAAA UAAGGCCUAC UUCACAAAGC GCCUUCCCCC GUAAAUGAUA UCAUCUCA A CUUAGUAUUA UACCCACACC CACCCAAGAA CAGGGUUU

GENBANK: GENBANK: MK321331.1

Macromolecule #12: tRNA

• Macromolecule: Name: tRNA / type: rna / ID: 12 / Number of copies: 1
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 22.961699 KDa

Sequence

String:

CAGAGUGUAG CUUAACACAA AGCACCCAAC UUACACUUAG GAGAUUUCAA CUUAACUUGA CCGCUCUGAC CA

GENBANK: GENBANK: LC530724.1

Macromolecule #55: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 55 / Number of copies: 3 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #56: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 56 / Number of copies: 102 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Macromolecule #57: N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin...

• Macromolecule: Name: N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide; type: ligand / ID: 57 / Number of copies: 1 / Formula: ZLD
• Molecular weight: Theoretical: 337.346 Da

Chemical component information

ChemComp-ZLD:
N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide / antibiotic*YM

Macromolecule #58: water

• Macromolecule: Name: water / type: ligand / ID: 58 / Number of copies: 4129 / Formula: HOH
• Molecular weight: Theoretical: 18.015 Da

Chemical component information

ChemComp-HOH:
WATER

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.4
• Vitrification: Cryogen name: ETHANE

Electron microscopy

• Microscope: FEI TALOS ARCTICA
• Image recording: Film or detector model: GATAN K3 (6k x 4k) / Average electron dose: 21.0 e/Ų
• Electron beam: Acceleration voltage: 200 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.0 µm / Nominal defocus min: 0.5 µm
• Experimental equipment: Model: Talos Arctica / Image courtesy: FEI Company

Image processing

• CTF correction: Type: PHASE FLIPPING AND AMPLITUDE CORRECTION
• Startup model: Type of model: NONE
• Final reconstruction: Resolution.type: BY AUTHOR / Resolution: 2.62 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 347872
• Initial angle assignment: Type: PROJECTION MATCHING
• Final angle assignment: Type: PROJECTION MATCHING