Entry Database : EMDB / ID : EMD-41028 Downloads & linksTitle Transporter associated with antigen processing (TAP) bound to the 9-mer peptide ILKEPVHGV Map data Details SampleComplex : Transporter associated with antigen processing bound to the 9-mer peptide ILKEPVHGVProtein or peptide : Antigen peptide transporter 1Protein or peptide : Antigen peptide transporter 2Protein or peptide : Transframe peptide Details Keywords ABC transporter / antigen processing / peptide transporter / MEMBRANE PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent / ABC-type peptide transporter activity / tapasin binding / ABC-type antigen peptide transporter / ABC-type peptide antigen transporter activity / TAP complex / TAP1 binding / oligopeptide export from mitochondrion / TAP2 binding / peptide antigen transport ... antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent / ABC-type peptide transporter activity / tapasin binding / ABC-type antigen peptide transporter / ABC-type peptide antigen transporter activity / TAP complex / TAP1 binding / oligopeptide export from mitochondrion / TAP2 binding / peptide antigen transport / MHC class Ib protein binding / cytosol to endoplasmic reticulum transport / ABC-type oligopeptide transporter activity / peptide transport / peptide transmembrane transporter activity / MHC class I protein binding / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / centriolar satellite / endoplasmic reticulum-Golgi intermediate compartment membrane / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / HIV-1 retropepsin / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / retroviral ribonuclease H / exoribonuclease H / response to molecule of bacterial origin / MHC class I peptide loading complex / exoribonuclease H activity / T cell mediated cytotoxicity / transmembrane transport / antigen processing and presentation of endogenous peptide antigen via MHC class I / ADP binding / defense response / host multivesicular body / DNA integration / viral genome integration into host DNA / positive regulation of T cell mediated cytotoxicity / RNA-directed DNA polymerase / viral penetration into host nucleus / establishment of integrated proviral latency / RNA stem-loop binding / phagocytic vesicle membrane / peptide antigen binding / RNA-directed DNA polymerase activity / host cell / RNA-DNA hybrid ribonuclease activity / Transferases; Transferring phosphorus-containing groups; Nucleotidyltransferases / protein transport / ER-Phagosome pathway / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / adaptive immune response / mitochondrial inner membrane / DNA-directed DNA polymerase / Hydrolases; Acting on ester bonds / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / nuclear speck / symbiont entry into host cell / lipid binding / host cell nucleus / endoplasmic reticulum membrane / host cell plasma membrane / virion membrane / structural molecule activity / endoplasmic reticulum / protein homodimerization activity / ATP hydrolysis activity / proteolysis / DNA binding / zinc ion binding / ATP binding / membrane / metal ion binding Similarity search - Function Antigen peptide transporter 2 / ABC transporter Tap-like / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter ... Antigen peptide transporter 2 / ABC transporter Tap-like / Type 1 protein exporter / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Ribonuclease H domain / RNase H type-1 domain profile. / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase domain / Reverse transcriptase (RT) catalytic domain profile. / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Ribonuclease H superfamily / Aspartic peptidase domain superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human) / Human immunodeficiency virus 1Method single particle reconstruction / cryo EM / Resolution : 3.5 Å Details AuthorsLee J / Oldham ML / Chen J Funding support United States, 1 items Details Hide detailsOrganization Grant number Country Howard Hughes Medical Institute (HHMI) United States
CitationJournal : To Be Published Title : Transporter associated with antigen processing (TAP) bound to the 9-mer peptide ILKEPVHGVAuthors : Lee J / Oldham ML / Chen J History Deposition Jun 9, 2023 - Header (metadata) release Jun 19, 2024 - Map release Jun 19, 2024 - Update Jun 19, 2024 - Current status Jun 19, 2024 Processing site : RCSB / Status : Released
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